Colon Capsule Endoscopy in the Diagnosis of Colon Polyps: Who Needs a Colonoscopy?

Koffas, Apostolos; Papaefthymiou, Apostolis; Laskaratos, Faidon-Marios; Kapsoritakis, Andreas; Epstein, Owen

doi:10.3390/diagnostics12092093

Cited by 9 publications

(5 citation statements)

References 106 publications

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“…In fact, mild adverse events occurred in 7.4% patients during CCE-2, mostly related to colon preparation, no severe adverse events occurred and none CCE was retained, which is in line with previous studies [18]. Completeness and colon preparation quality are relevant factors associated with missed lesions and our results reflected the published data [19]. In our study, despite 28.7% CCE were incomplete, only 6.3% patients could not achieve a complete colon examination after CCE after CCE, strengthening the role of CCE in patients with incomplete colonoscopy.…”

Section: Discussionsupporting

confidence: 92%

TOP 100 and detection of colorectal lesions in colon capsule endoscopy: more than meets the eye

Lima Capela,

Arieira,

Xavier

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

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Colon capsule endoscopy (CCE) is a well-known method for the detection of colorectal lesions. Nevertheless, there are no studies reporting the accuracy of TOP 100, a CCE software tool, for the automatic detection of colorectal lesions in CCE. We aimed to evaluate the performance of TOP 100 in detecting colorectal lesions in patients submitted to CCE for incomplete colonoscopy compared with classic reading. A retrospective cohort study including adult patients submitted to CCE (PillCam COLON 2; Medtronic) for incomplete colonoscopy. Blinded for each other’s evaluation, one experienced reader analyzed the TOP 100 images and the other performed classic reading to identify colorectal lesions. Detection of colorectal lesions, namely polyps, angioectasia, blood, diverticula, erosions/ulcers, neoplasia, and subepithelial lesions was assessed and TOP 100 performance was evaluated compared with the gold standard (classic reading). A total of 188 CCEs were included. Prevalence of colorectal lesions, polyps, angioectasia, blood, diverticula, erosions/ulcers, neoplasia, and subepithelial lesions were 77.7, 54.3, 8.5, 1.6, 50.0, 0.5, 0.5, and 1.1%, respectively. TOP 100 had a sensitivity of 92.5%, specificity of 69.1%, negative predictive value of 72.5%, positive predictive value of 91.2%, and accuracy of 87.2% for detecting colorectal lesions. TOP 100 had a sensitivity of 89.2%, specificity of 84.9%, negative predictive value of 86.9%, positive predictive value of 87.5%, and accuracy of 87.2% in detecting polyps. All colorectal lesions other than polyps were identified with 100% accuracy by TOP 100. TOP 100 has been shown to be a simple and useful tool in assisting the reader in the prompt identification of colorectal lesions in CCE.

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Section: Discussionsupporting

confidence: 92%

TOP 100 and detection of colorectal lesions in colon capsule endoscopy: more than meets the eye

Lima Capela,

Arieira,

Xavier

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

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“…With regard to small intestinal CD, SBCE is established as the most sensitive mucosal imaging modality when compared to barium follow-up, MRI, and CT enterography and colonoscopy with terminal ileoscopy. Unlike SBCE and ileo-colonoscopy, PCC delivers video images of the entire digestive tract, offering the opportunity to stage and monitor the disease from stomach to rectum with a single minimally invasive investigation [1][2][3]. This review indicates that, currently, there is considerable heterogeneity in the published reports.…”

Section: Discussionmentioning

confidence: 99%

“…Two subsequent generations of SBCE were developed to improve battery efficiency, field of vision, and image resolution. A number of publications have reported the superiority and safety of SBCE for the grading of the severity and extent of small bowel CD, and the third-generation capsule is now firmly established in the Crohn's disease management pathway [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Is Panenteric PillcamTM Crohn’s Capsule Endoscopy Ready for Widespread Use? A Narrative Review

et al. 2023

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Patients diagnosed with Crohn’s disease are increasingly subjected to repeat colonoscopic and radiological examinations to assess the extent of the disease severity and the effects of treatment. PillcamTM Crohn’s video capsule, a modified colon capsule, was developed to generate a minimally invasive mouth to rectum video of the gastrointestinal tract. The capsule provides a wide-angle panoramic mucosal view to assess inflammation, ulceration, stenosis, disease extent, and effect of treatment. This review summarizes the evidence of its utility in both adult and paediatric Crohn’s disease and reviews the scoring systems used to quantify findings. The literature survey indicates that the PillcamTM Crohn’s capsule offers high sensitivity and specificity for the detection of inflammatory lesions and the extent and distribution of disease, and it could be considered a reliable imaging modality in both adults and childhood with Crohn’s disease.

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“…There has been widespread adoption of colon screening programs for detecting adenomas and early stages of cancer, with the optimal age decreasing over the years, resulting in a greater demand for screening services. 40 – 42 CCE is an attractive option for patients undergoing colon screening due to its minimally invasive nature.…”

Section: Use Of Cce In Clinical Practicementioning

confidence: 99%

Clinical utility of colon capsule endoscopy: a moving target?

Jalayeri Nia,

Arasaradnam,

Koulaouzidis

2023

Therap Adv Gastroenterol

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The purpose of this article is to provide an overview of white light colon capsule endoscopy’s current clinical application, concentrating on its most recent developments. Second-generation colon capsule endoscopy (CCE2) is approved by the FDA for use as an adjunctive test in patients with incomplete colonoscopy and within Europe in patients at average risk, those with incomplete colonoscopies or those unwilling to undergo conventional colonoscopies. Since the publication of European Society of GI Endoscopy guidelines on the use of CCE, there has been a significant increase in comparative studies on the diagnostic yield of CCE. This paper discusses CCE2 in further detail. It explains newly developed colon capsule system and the current status on the use of CCE, it also provides a comprehensive summary of systematic reviews on the implementation of CCE in colorectal cancer screening from a methodological perspective. Patients with ulcerative colitis can benefit from CCE2 in terms of assessing mucosal inflammation. As part of this review, performance of CCE2 for assessing disease severity in ulcerative colitis is compared with colonoscopy. Finally, an assessment if CCE can become a cost-effective clinical service overall.

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Colon Capsule Endoscopy in the Diagnosis of Colon Polyps: Who Needs a Colonoscopy?

Cited by 9 publications

References 106 publications

TOP 100 and detection of colorectal lesions in colon capsule endoscopy: more than meets the eye

TOP 100 and detection of colorectal lesions in colon capsule endoscopy: more than meets the eye

Is Panenteric PillcamTM Crohn’s Capsule Endoscopy Ready for Widespread Use? A Narrative Review

Clinical utility of colon capsule endoscopy: a moving target?

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