Colon Cancer Tumor Location Defined by Gene Expression May Disagree With Anatomic Tumor Location

Cannon, Emily; Buechler, Steven

doi:10.1016/j.clcc.2019.02.002

Cited by 8 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In distal CRC tissues, though Fusobacteria-high individuals had the least survival time than the Fusobacteria-low/negative individuals, the difference was not statistically significant. This finding has important implications in that because proximal colon cancer usually has a worse prognosis and is prone to peritoneal metastasis ( Petrelli et al, 2017 ; Cannon and Buechler, 2019 ), this highly aggressive microorganism of Fusobacteria may act as one of accomplices behind the scenes. Some scholars discovered that Fusobacterium adhered to human epithelial cells ( Han et al, 2000 ; Han et al, 2004 ), activated WNT signals ( Rubinstein et al, 2013 ), and promoted oncogene expression ( Rubinstein et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

“…This is despite notable improvements in the disease screening, prevention, and treatment strategies over the past decade. CRC originating proximally (right) or distally (left) exhibits differences in embryonic origin, age-specific and sex-specific morbidity, clinical manifestation, pathological characteristics, and development ( Petrelli et al, 2017 ; Cannon and Buechler, 2019 ). At the molecular level, BRAF mutation, microsatellite instability (MSI), the CpG island methylator phenotype (CIMP)-high, or the consensus molecular subtype (CMS) CMS1 is more likely to occur in proximal CRC ( Missiaglia et al, 2014 ; Guinney et al, 2015 ; Lee et al, 2017 ), while chromosome instability, TP53 or APC mutation, or CMS2 is more likely to occur in distal CRC ( Missiaglia et al, 2014 ; Guinney et al, 2015 ; Loree et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

“…At the molecular level, BRAF mutation, microsatellite instability (MSI), the CpG island methylator phenotype (CIMP)-high, or the consensus molecular subtype (CMS) CMS1 is more likely to occur in proximal CRC ( Missiaglia et al, 2014 ; Guinney et al, 2015 ; Lee et al, 2017 ), while chromosome instability, TP53 or APC mutation, or CMS2 is more likely to occur in distal CRC ( Missiaglia et al, 2014 ; Guinney et al, 2015 ; Loree et al, 2018 ). Moreover, proximal CRC commonly has a poorer prognosis than distal CRC ( Petrelli et al, 2017 ; Cannon and Buechler, 2019 ). These differences between anatomical segments reflect a complex interaction between different environmental exposures of colorectal epithelial cells to carcinogenic or protective factors and the different inherent biological features affecting the risk of anatomical subsite carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tumor-Associated Microbiota in Proximal and Distal Colorectal Cancer and Their Relationships With Clinical Outcomes

Jin

Shang

et al. 2021

Front. Microbiol.

View full text Add to dashboard Cite

The proximal and distal subsites of colorectal cancer (CRC) have distinct differences in their embryonic origin, epidemiology, and prognosis. Therefore, they are not considered as the same disease. However, the possible difference in microbial characterization of the two subsites of CRC is still unclear. In this study, we explored tumor microbiota diversity and composition difference in patients with proximal (N = 187) and distal CRCs (N = 142). This was carried out on cancer tissues and adjacent tissues using bacterial 16S rRNA sequencing. The Kaplan–Meier method was used to analyze the correlation between differential flora and overall survival rate of the patients. It was found that there were significant differences in tumor microbial characteristics between the proximal and distal CRC tissues. The microbiota communities were distinctly richer in the proximal colon tumor tissues than in the distal CRC tissues. Microbial diversity and structure were relatively constant in the paracancerous normal tissues of the proximal and distal colorectum. Generally, microbial communities of CRC tumor tissues were composed of Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes. Alpha diversity in the proximal and distal CRC tumor tissues was closely related to specific microflora. The abundance of Fusobacteria was associated with age of patient, tumor diameter, and tumor microsatellite instability (MSI) status of the patients. Moreover, Fusobacteria enrichment was associated with poor prognosis especially in patients with proximal colon cancers, but not in patients with distal CRC. In conclusion, proximal and distal subsites of the CRC present distinct microbiota diversity and community structures. The differences indicate that there are different risk factors across anatomical subsites of CRC, which may provide a new strategy for precise prevention and treatment of CRC in the future.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tumor-Associated Microbiota in Proximal and Distal Colorectal Cancer and Their Relationships With Clinical Outcomes

Jin

Shang

et al. 2021

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…The disease presents differently between men and women, developing in different parts of the colon and often with a different morphology ( Schmuck et al., 2020 ). In addition, it is known that colon cancer tumors differ in responsiveness to treatment, susceptibility to mutations, and expected patient survival rates according to the tumor’s anatomic location ( Cannon and Buechler, 2019 ; Liao et al., 2018 ; Phipps et al., 2013 ). It is thus imperative to determine the innate and aging-associated differences in different parts of the colon to better treat or prevent the development of colon cancer.…”

Section: Introductionmentioning

confidence: 99%