Colon cancer presenting with polymyositis—A case report

Rominiyi, Ola; Broman, Daniel; Rajaganeshan, R; Selvasekar, CR

doi:10.1016/j.ijscr.2011.07.004

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…One characteristic of colorectal tumor progression is patient weight reduction and the presence of blood in the stool [27,28]. Body weight decrease is attributed to chronic constipation and abdominal pain whereas bleeding can be caused by the friction and shear of the stool with the projecting interstitial tumors [29,30].…”

Section: Resultsmentioning

confidence: 99%

Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer

et al. 2012

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Colorectal cancer is a significant source of morbidity and mortality in the United States and other Western countries. Oral delivery of therapeutics remains the most patient accepted form of medication. The development of an oral delivery formulation for local delivery of chemotherapeutics in the gastrointestinal tract can potentially alleviate the adverse side effects including systemic cytotoxicity, as well as focus therapy to the lesions. Here we develop an oral formulation of the chemotherapeutic drug oxaliplatin for the treatment of colorectal cancer. Oxaliplatin was encapsulated in pH sensitive, mucoadhesive chitosan-coated alginate microspheres. The microparticles were formulated to release the chemotherapeutics after passing through the acidic gastric environment thus targeting the intestinal tract. In vivo, these particles substantially reduced the tumor burden in an orthotopic mouse model of colorectal cancer, and reduced mortality.

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Section: Resultsmentioning

confidence: 99%

Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer

et al. 2012

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“…Various population-based studies have shown association of colorectal cancer with DM [5,6]. However, its association with PM is limited to few case reports [8][9][10][11]. The diagnosis of cancer can be before, after or simultaneously with myositis [6].…”

Section: Discussionmentioning

confidence: 99%

Polymyositis, COVID-19 and Rectal Carcinoma: A Rare Case Presentation

Risal,

Pandey,

Regmi

et al. 2024

Clin Infect Immun

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Association of idiopathic inflammatory myopathies (IIMs) with malignancy has been well recognized for a long time. However, its association with coronavirus disease 2019 (COVID-19) which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is rare. Here we report a case of a 73-year-old male under treatment for rectal carcinoma who was admitted for mild COVID-19. He developed progressive bilateral upper and lower limb weakness which was finally diagnosed as polymyositis. He was given high-dose steroid along with methotrexate to which he responded very well. This case highlights the fact that inflammatory myopathy should be suspected in elderly patients who present with generalized weakness especially in the background of malignancy. The association of COV-ID-19 with myositis needs further studies.

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“…Patient history and physical examination are essential components in the diagnosis of gastrointestinal tract tumors. Some of the common symptoms are abdominal pain, abdominal distention, and bloody stool, and the specific symptoms of colorectal cancer are changes in bowel habits and intestinal obstruction [ 12 – 14 ]. Abdominal examination and digital rectal examination are important tools in the diagnosis of gastrointestinal tract tumors.…”

Section: Discussionmentioning

confidence: 99%

Regular gastroscopy and colonoscopy during the evaluation of urachal cancer: do we really need them?

Luo,

Cai,

et al. 2023

BMC Cancer

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Purpose Urachal cancer is similar to gastrointestinal adenocarcinoma in histology, and gastroscopy/colonoscopy is often administered during perioperative evaluation. However, gastroscopy and colonoscopy have corresponding disadvantages. This study discusses whether gastroscopy/colonoscopy is truly necessary for patients with urachal cancer. Patients and methods A total of 166 bladder adenocarcinoma cases diagnosed at Sun Yat-sen University Cancer Center were retrospectively reviewed and divided into two groups (urachal cancer and nonurachal cancer), and perioperative evaluations were retrieved. Results There were 78 patients with urachal cancer, the median age was 48 years, and 59 were male. Perioperative gastroscopy/colonoscopy revealed 5 intestinal polyps and 1 adenoma during these evaluations, and no primary gastrointestinal cancer was found. Meanwhile, preoperative imaging evaluation did not detect significant gastrointestinal lesions. For 88 patients with nonurachal cancer, including primary bladder adenocarcinoma and metastatic tumors from gastrointestinal cancer, the median age was 56 years, and 64 were male. Preoperative imaging evaluation demonstrated 36 cases of gastrointestinal lesions, and 32 were confirmed by gastroscopy/colonoscopy; the other 4 were negative. Another 4 cases of colon cancer were detected by regular colonoscopy for suspected primary bladder adenocarcinoma. In all, 35 cases of colon cancer and 1 case of gastric cancer were identified by endoscopic examination. The diagnostic consistency of imaging and gastrointestinal endoscopy was favorable (P < 0.001), and the negative predictive value and diagnostic efficiency of imaging were 96.9% and 94.6%, respectively. Conclusions The vast majority of gastrointestinal cancer cases can be identified by assessment of the patient’s clinical symptoms, meticulous physical examination, and imaging evaluation. We recommend that gastroscopy/colonoscopy only be applied to patients with urachal cancer when the above examinations are positive.

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Colon cancer presenting with polymyositis—A case report

Abstract: The diagnosis of polymyositis in the elderly population should raise suspicion of an underlying malignancy.

Cited by 6 publications

References 10 publications

Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer

Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer

Polymyositis, COVID-19 and Rectal Carcinoma: A Rare Case Presentation

Regular gastroscopy and colonoscopy during the evaluation of urachal cancer: do we really need them?

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