Colon cancer and colorectal cancer: Prevention and treatment by potential natural products

Islam, Md. Rezaul; Akash, Shopnil; Rahman, Md. Mominur; Nowrin, Feana Tasmim; Akter, Tamanna; Shohag, Sheikh; Rauf, Abdur; Aljohani, Abdullah S.M.; Simal-Gándara, Jesús

doi:10.1016/j.cbi.2022.110170

Cited by 87 publications

(48 citation statements)

References 230 publications

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“…Treatment choices for triple-negative breast cancer are more limited than those for other kinds of invasive breast cancer. This is due to the fact that cancer cells do not possess the estrogen or progesterone receptors or enough of the HER2 protein for hormone treatment or targeted HER2 medicines to be effective against the disease [15][16][17]. So, even though TNBC has been more invasive in women and has affected numerous women worldwide, there is no presently acknowledged treatment for targeting this TNBC [18,19].…”

Section: Introductionmentioning

confidence: 99%

Computational investigation of Scutellarein derivatives as an inhibitor against triple-negative breast cancer by Quantum calculation, and drug-designed approaches

Akash

Aovi

Azad

et al. 2023

Preprint

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Triple-negative breast cancer accounts for 10-15% of all breast tumors (TNBC). Triple-negative breast cancer lacks either estrogen or progesterone receptors (ER or PR), producing either too little or too much HER2. (All three tests result in "negative" results for the cells.) These cancers are more common in women under 40 who are Black or have the BRCA1 mutation. TNBC differs from other types of invasive breast cancer in that it has fewer treatment options, a worse prognosis, and grows and spreads more quickly (outcome). So, first of all, the protein of triple-negative breast cancer was collected from the PDB database having the most stable configuration, and a natural bioactive molecule, Scutellarein, was selected. Scutellarein is well-known to possess anti-cancer properties, so its derivatives were chosen to design anti-cancer drugs through computational tools. In this case, the functional group has applied and modified structural activity relationship methods. Then, the pass prediction score was taken, which indicates the probability of active (Pa) and the probability of inactive (Pi). After that, other in-silco approaches, such as the ADMET parameter, and quantum calculation by Density Functional Theory (DFT), have been conducted. Finally, molecular docking and dynamics have been evaluated against TNBC to determine the binding affinity and stability. Scutellarein derivatives (DM03 at -10.7 kcal/mol, DM04 at -11.0 kcal/mol) have been reported to have a maximum tendency for binding against TNBC. Besides, the molecular dynamic simulation was performed at 100ns and described by root-mean-square deviation (RMSD) and root-mean-square fluctuation (RMSF), which are much more stable compounds. The pharmacokinetics specifications for a suitable therapeutic candidate were satisfied by these molecules, like as non-carcinogenic, minimal to aquatic and non-aquatic toxicity. Almost all the molecules are highly soluble in the aqueous system. These all-computational data suggested that they might be suitable as a medication for the inhibition of TNBC, and further experimental studies should be carried out.

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Section: Introductionmentioning

confidence: 99%

Computational investigation of Scutellarein derivatives as an inhibitor against triple-negative breast cancer by Quantum calculation, and drug-designed approaches

Akash

Aovi

Azad

et al. 2023

Preprint

Self Cite

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“…Recent research has demonstrated plants as promising sources of immunomodulators [6][7][8]. Tis is due to their diverse biological activities, fewer side efects, easy availability, and afordability [9][10][11][12][13][14][15]. Numerous phytochemicals have been approved for clinical trials, and others, including quercetin and resveratrol, among others, have undergone rigorous clinical trials [16].…”

Section: Introductionmentioning

confidence: 99%

Terminalia brownii Fresen: Stem Bark Dichloromethane Extract Alleviates Pyrogallol‐Induced Suppression of Innate Immune Responses in Swiss Albino Mice

Mbiri

Ogila

Kisangau

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Terminalia brownii is widely used in folklore medicine and has diverse biological activities. However, its effect on the immune system is yet to be studied. Therefore, our study evaluated the immunomodulatory effect of T. brownii on nonspecific immunity. Innate immunity is the initial defence phase against pathogens or injuries. Dichloromethane plant extracts were tested on female Swiss albino mice and Wister rats. The effect of the extract on innate immunity was assessed via total and differential leukocyte counts, tumor necrosis factor-alpha, and nitric oxide production by mouse macrophages. The 3-(4, 5-dimethyl thiazolyl-2)-2, 5-diphenyltetrazolium bromide assay was employed for viability testing. Phytochemical profiling was carried out using gas chromatography-mass spectrometry, while toxicity studies were carried out following the Organization for Economic Cooperation and Development guidelines. Our results demonstrated that administration of T. brownii stem bark dichloromethane extract to pyrogallol-immuno compromised mice significantly ( p < 0.05 ) increased total and differential leukocyte counts compared with the control. The extract showed no adverse effect on the viability of Vero cells and macrophages and significantly ( p < 0.05 ) augmented tumor necrosis factor-alpha and nitric oxide production. Hexadecanoic acid, linoleic acid, octadecanoic acid, squalene, campesterol, stigmasterol, and β-sitosterol, all of which stimulate, were identified in the extract. The extract did not cause any death or toxic signs in rats. In conclusion, T. brownii dichloromethane extract has an immunoenhancing effect on innate immune responses and is not toxic. The observed immunoenhancing impact of the extract was attributed to the presence of the identified compounds. The results of this study provide crucial ethnopharmacological leads towards the development of novel immunomodulators for managing immune-related disorders.

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“…Histologically, NSCLC is further divided into three subtypes: adenocarcinoma, squamous-cell carcinoma, and large cell carcinoma [3]. Chemotherapy, radiotherapy, surgery, and targeted therapy are the main methods used to treat lung cancer [4][5][6][7][8][9][10]. At the terminal stage of lung cancer, chemotherapy and targeted therapy play important roles in disease management.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect and Mechanism of Ursolic Acid on Cisplatin‐Induced Resistance and Stemness in Human Lung Cancer A549 Cells

Fan

Wang²,

Chen

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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The survival rate of lung cancer patients remains low largely due to chemotherapy resistance during treatment, and cancer stem cells (CSCs) may hold the key to targeting this resistance. Cisplatin is a chemotherapy drug commonly used in cancer treatment, yet the mechanisms of intrinsic cisplatin resistance have not yet been determined because lung CSCs are hard to identify. In this paper, we proposed a mechanism relating to the function of ursolic acid (UA), a new drug, in reversing the cisplatin resistance of lung cancer cells regulated by CSCs. Human lung cancer cell line A549 was selected as the model cell and treated to become a cisplatin-resistant lung cancer cell line (A549-CisR), which was less sensitive to cisplatin and showed an enhanced capability of tumor sphere formation. Furthermore, in the A549-CisR cell line expression, levels of pluripotent stem cell transcription factors Oct-4, Sox-2, and c-Myc were increased, and activation of the Jak2/Stat3 signaling pathway was promoted. When UA was applied to the cisplatin-resistant cells, levels of the pluripotent stem cell transcription factors were restrained by the inhibition of the Jak2/Stat3 signaling pathway, which reduced the enrichment of tumor stem cells, and in turn, reversed cisplatin resistance in lung cancer cells. Hence, as a potential antitumor drug, UA may be able to inhibit the enrichment of the lung CSC population by inhibiting the activation of the Jak2-Stat3 pathway and preventing the resistance of lung cancer cells to cisplatin.

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Colon cancer and colorectal cancer: Prevention and treatment by potential natural products

Cited by 87 publications

References 230 publications

Computational investigation of Scutellarein derivatives as an inhibitor against triple-negative breast cancer by Quantum calculation, and drug-designed approaches

Computational investigation of Scutellarein derivatives as an inhibitor against triple-negative breast cancer by Quantum calculation, and drug-designed approaches

Terminalia brownii Fresen: Stem Bark Dichloromethane Extract Alleviates Pyrogallol‐Induced Suppression of Innate Immune Responses in Swiss Albino Mice

Inhibitory Effect and Mechanism of Ursolic Acid on Cisplatin‐Induced Resistance and Stemness in Human Lung Cancer A549 Cells

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