Colon and rectal cancer in the elderly.

Limpert, Patricia A.; Longo, Walter E.; Kelemen, Pond R.; Vernava, Anthony M.; Bahadursingh, Anil; Johnson, Frank E.; Limpert, Jonathan N; Kaminski, Donald L.

doi:10.1016/j.critrevonc.2003.05.003

Cited by 19 publications

(5 citation statements)

References 18 publications

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“…Various studies have investigated potential factors that influence outcomes after surgery for rectal cancer [2, 6, 10, 16, 17, 18, 19]. Type of surgery and gender have been found to influence QOL after surgery for rectal cancer, but most studies lack appropriate methodology and inclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

Impact of Age on Quality of Life in Patients with Rectal Cancer

Schmidt

Bestmann²,

Küchler³

et al. 2005

World j. surg.

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Some studies indicate that age at the time of surgery has a general effect on outcomes. The impact of age on the quality of life (QOL) of patients with rectal cancer, however, has not been investigated. The present study was conducted to address this issue. Over a 5-year period the European Organization for Research and Treatment of Cancer (EORTC)-QLQ-C-30 and a tumor-specific module were prospectively administered to patients before surgery, at discharge, and at 3, 6, 12, and 24 months postoperatively. Comparisons were made between age groups. A total of 519 patients participated in the study. QOL data were available for 253 patients. Significant differences were observed only between patients aged 69 years and younger (< or =69 years) (169/253) and those aged 70 years and older (> or =70 years) (85/253). Physical and role functioning was better for patients < or =69 years; patients > or =70 years suffered from increased pain and fatigue. Younger patients had more difficulty with sexual enjoyment, and over time sexual strain was worse for patients aged > or =70 years during the early postoperative period but improved, whereas patients aged < or =69 years had increasing levels of strain over time. The findings in this study confirmed that QOL is dynamic over time and that age has an impact on QOL and sexuality. Patients aged > or =70 years are affected by impaired physical functioning, global health, and fatigue, whereas increased treatment strain during the early postoperative period improves over time. Patients aged < or =69 years experience increased strain because of impaired sexual function.

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Section: Discussionmentioning

confidence: 99%

Impact of Age on Quality of Life in Patients with Rectal Cancer

Schmidt

Bestmann²,

Küchler³

et al. 2005

World j. surg.

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“…[7][8][9] The most common malignant tumour of the large intestine is adenocarcinoma. [23][24][25] This major type of epithelial tumour forms moderate to well-differentiated glands and secretes variable amounts of mucin. The other major morphologic type of carcinoma in the colon is mucinous carcinoma, [24][25][26] in which there is abundant mucin secretion, and in the tumour cells a large vacuole of mucin displaces the nucleus to one side; thereby, these cells are called ''signet-ring'' cells.…”

Section: Normal Adenomatous and Carcinomatous Colonsmentioning

confidence: 99%

“…[23][24][25] This major type of epithelial tumour forms moderate to well-differentiated glands and secretes variable amounts of mucin. The other major morphologic type of carcinoma in the colon is mucinous carcinoma, [24][25][26] in which there is abundant mucin secretion, and in the tumour cells a large vacuole of mucin displaces the nucleus to one side; thereby, these cells are called ''signet-ring'' cells. In the colon, it is also possible to see scirrhous tumours that are uncommon and characterised by sparse gland formation with marked desmoplasia and fibrous tissue surrounding glandular structures.…”

Section: Normal Adenomatous and Carcinomatous Colonsmentioning

confidence: 99%

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Mucin Macromolecules in Normal, Adenomatous, and Carcinomatous Colon: Evidence for the Neotransformation

Aksoy

Akinci

2004

Macromolecular Bioscience

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Mucins are high molecular-weight glycoproteins having oligosaccharides attached to serine or threonine residues of the mucin core protein backbone by O-glycosidic linkages. They are major components of mucus, covering the luminal surfaces of epithelial respiratory, gastrointestinal and reproductive tracts, and responsible for its viscoelastic properties. The core proteins of mucins are encoded by different mucin genes. Aberrations in the cell surface carbohydrates including mucins have been regarded as a universal characteristic of the malignant transformation of cells. These alterations are considered to be relevant to the abnormal behaviour of cancer cells, such as altered cell adhesion or metastasis, and to the avoidance of immunological defence.

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“…Compared to the average risk individuals, patients with early onset CRC generally have a poorer outcome (5) whilst those presenting over age 80 years, albeit that there are challenges with surgical management because of associated co-morbidities, tend to do better (6). This may be because the tumours are biologically less aggressive (7,8).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Features of Colorectal Cancer at the Extremes of Age

Plummer¹,

Ferron-Boothe²,

Leake³

et al. 2017

West Indian Med J

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Objective: To determine the clinicopathological features of patients with colorectal cancer (CRC) at the extremes of age and compare differences across the younger and older age groups.Method: Data was obtained from the CRC Registry for patients diagnosed during the 4-year period commencing January 1, 2011. Variables analyzed included clinical presentation, tumour site, stage, various histopathologic features and adequacy of nodal resection. Results:Of 900 cases entered into our database, 59 were age 40 and under and 119 were age 80 and over (7% and 13% respectively). These patients were referenced with patients diagnosed between age 50-70 years and they formed the basis of this study. Common clinical presentations across both groups were bleeding per rectum (26% vs 17%), change in bowel habits (both 31%) and abdominal pain (16% vs 14), with no statistical difference between groups (P = 0.556). Most tumours occurred in the rectum (27%) and the sigmoid colon (26%) with 72% of all tumours being moderately differentiated. Comparison across age groups revealed equivalent tumour distribution. However, younger patients had more signet ring histology (15% vs 4%; P = 0.035) while there was a trend towards older patients having perineural invasion (15% vs 7%; P = 0.088). All categories of patients had similar tumour (T) stage while significantly more nodes were examined for younger patients (P = 0.002). The number of positive nodes did not differ between the two extremes (P = 0.500). Conclusions:This review demonstrates that while there are a few measurable differences in CRC in patients at the extremes of age, most patients were overall similar in their clinical symptoms, tumour distribution and stage at diagnosis.

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Colon and rectal cancer in the elderly.

Cited by 19 publications

References 18 publications

Impact of Age on Quality of Life in Patients with Rectal Cancer

Impact of Age on Quality of Life in Patients with Rectal Cancer

Mucin Macromolecules in Normal, Adenomatous, and Carcinomatous Colon: Evidence for the Neotransformation

Clinicopathological Features of Colorectal Cancer at the Extremes of Age

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