Coloboma contiguous gene deletion encompassingSnap alters hippocampal plasticity

Steffensen, Scott C.; Wilson, Michael C.; Henriksen, Steven J.

doi:10.1002/(sici)1098-2396(199603)22:3<281::aid-syn11>3.0.co;2-2

Cited by 26 publications

(3 citation statements)

References 58 publications

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“…Treatment with low doses of d-amphetamine (2–4 mg/kg) reduces hyperactivity, whereas methylphenidate (2–32 mg/kg) increases hyperactivity [ 225 ]. In addition, this mouse model has a mutation in the synaptosome-associated protein 25 (SNAP25) gene, and the authors suggest that the behavioural performance of coloboma mice could be related to SNAP25 dysfunction [ 225 , 228 ]. Further investigations are needed to better understand the mechanisms.…”

Section: Mouse Models Of Asd and Adhd Researchmentioning

confidence: 99%

Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish

Dougnon

Matsui

2022

IJMS

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Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are two debilitating neurodevelopmental disorders. The former is associated with social impairments whereas the latter is associated with inattentiveness, hyperactivity, and impulsivity. There is recent evidence that both disorders are somehow related and that genes may play a large role in these disorders. Despite mounting human and animal research, the neurological pathways underlying ASD and ADHD are still not well understood. Scientists investigate neurodevelopmental disorders by using animal models that have high similarities in genetics and behaviours with humans. Mice have been utilized in neuroscience research as an excellent animal model for a long time; however, the zebrafish has attracted much attention recently, with an increasingly large number of studies using this model. In this review, we first discuss ASD and ADHD aetiology from a general point of view to their characteristics and treatments. We also compare mice and zebrafish for their similarities and discuss their advantages and limitations in neuroscience. Finally, we summarize the most recent and existing research on zebrafish and mouse models of ASD and ADHD. We believe that this review will serve as a unique document providing interesting information to date about these models, thus facilitating research on ASD and ADHD.

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Section: Mouse Models Of Asd and Adhd Researchmentioning

confidence: 99%

Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish

Dougnon

Matsui

2022

IJMS

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“…Additional rodent models for ADHD have been created by genetic engineering to generate an ADHD-like phenotype, such as the SNAP-25 deficient mouse mutant coloboma [[21-23], reviewed in [24]] and the dopamine transporter knockout mouse (DAT-KO) [e.g. [25,26]].…”

Section: Introductionmentioning

confidence: 99%

Owner reports of attention, activity, and impulsivity in dogs: a replication study

Lit

Schweitzer

Iosif³

et al. 2010

Behavioral and Brain Functions

117

119

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BackgroundWhen developing behaviour measurement tools that use third party assessments, such as parent report, it is important to demonstrate reliability of resulting scales through replication using novel cohorts. The domestic dog has been suggested as a model to investigate normal variation in attention, hyperactivity, and impulsive behaviours impaired in Attention Deficit Hyperactive Disorder (ADHD). The human ADHD Rating Scale, modified for dogs and using owner-directed surveys, was applied in a European sample. We asked whether findings would be replicated utilizing an Internet survey in a novel sample, where unassisted survey completion, participant attitudes and breeds might affect previous findings.MethodsUsing a slightly modified version of the prior survey, we collected responses (n = 1030, 118 breeds representing 7 breed groups) primarily in the United States and Canada. This study was conducted using an Internet survey mechanism.ResultsReliability analyses confirmed two scales previously identified for dogs (inattention [IA], hyperactivity-impulsivity [HA-IM]). Models including age, training status, and breed group accounted for very little variance in subscales, with no effect of gender.ConclusionsThe factor invariance demonstrated in these findings confirms that owner report, using this modified human questionnaire, provides dog scores according to "inattention" and "hyperactivity-impulsivity" axes. Further characterization of naturally occurring variability of attention, activity, and impulsivity in domestic dogs may provide insight into genetic backgrounds underlying behaviours impaired in attention and associated disorders.

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“…Although the pharmacological cause for this difference is unknown, it probably reflects heterogeneity in the neurochemical and possibly genetic basis of ADHD. Moreover, in addition to hyperactivity, coloboma mutant mice are delayed in acquiring certain complex neonatal motor skills [48], and exhibit deficits in hippocampal physiology, including loss of long-term potentiation and increased paired-pulse inhibition [49]. Whether these additional abnormalities in neural function result from a deficiency of SNAP-25 expression, and importantly reflect the delayed age-inappropriate behaviour and cognitive impairments seen in ADHD, needs to be established.…”

Section: Figure 3 Hyperkinetic Behaviour Of Coloboma Mutants Is Rescumentioning

confidence: 99%

SNAP-25, enSNAREd in neurotransmission and regulation of behaviour

Wilson

Mehta

Hess

1996

Biochemical Society Transactions

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Coloboma contiguous gene deletion encompassingSnap alters hippocampal plasticity

Cited by 26 publications

References 58 publications

Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish

Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish

Owner reports of attention, activity, and impulsivity in dogs: a replication study

SNAP-25, enSNAREd in neurotransmission and regulation of behaviour

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