Colloidal suspensions in external rotating electric field: experimental studies and prospective applications in physics, material science, and biomedicine

Yakovlev, Egor V.; Troshina, Anna V.; Korsakova, Sofia A.; Andronik, M.; Rodionov, Ilya A.; Aliev, I. N.; Zaytsev, Kirill I.; Черкасова, О. П.; Tuchin, Valery V.; Yurchenko, Stanislav O.

doi:10.1117/12.2315134

Cited by 3 publications

(1 citation statement)

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“…For the first time, the effect of rotating electric fields was shown on the healthy human red blood cells. The cells become sensitive to the electric field and can be collected in threads [167]. Remote control over the cells allows not only for assembling their clusters but also distributing them in a controlled manner, solving problems related to thrombosis, for example.…”

Section: Electric Fields In Targeted Drug Deliverymentioning

confidence: 99%

Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials

Voronin

Abalymov

Svenskaya

et al. 2021

IJMS

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The increased research activity aiming at improved delivery of pharmaceutical molecules indicates the expansion of the field. An efficient therapeutic delivery approach is based on the optimal choice of drug-carrying vehicle, successful targeting, and payload release enabling the site-specific accumulation of the therapeutic molecules. However, designing the formulation endowed with the targeting properties in vitro does not guarantee its selective delivery in vivo. The various biological barriers that the carrier encounters upon intravascular administration should be adequately addressed in its overall design to reduce the off-target effects and unwanted toxicity in vivo and thereby enhance the therapeutic efficacy of the payload. Here, we discuss the main parameters of remote-controlled drug delivery systems: (i) key principles of the carrier selection; (ii) the most significant physiological barriers and limitations associated with the drug delivery; (iii) major concepts for its targeting and cargo release stimulation by external stimuli in vivo. The clinical translation for drug delivery systems is also described along with the main challenges, key parameters, and examples of successfully translated drug delivery platforms. The essential steps on the way from drug delivery system design to clinical trials are summarized, arranged, and discussed.

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Section: Electric Fields In Targeted Drug Deliverymentioning

confidence: 99%