Colloidal soft matter as drug delivery system

Bonacucina, Giulia; Cespi, Marco; Misici‐Falzi, Monica

doi:10.1002/jps.21423

Cited by 133 publications

(92 citation statements)

References 404 publications

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“…As previously reported, unsaturated fatty acids can incur oxidative reactions, altering the permeability of the liposomal bilayers [37] and if the degree of unsaturation of the fatty acid side chains is too high, there is a possibility that stable liposomes might not be formed [38]. In another study, it was reported that the average liposome size varies between 30 and 300 nm, depending on the lipid composition and ionic strength of the lipid mixture during liposome formation.…”

Section: Liposome Characterizationmentioning

confidence: 99%

“…Furthermore, differences among the prepared formulations could be attributed to several factors, such as lipid type and dose, interactions between the drug and lipid bilayer, as well as the lipid-PEG conjugate in the case of stealth liposomes [58]. Each type of phospholipid affects the efflux rate in a different way, e.g., a higher degree of saturation and an increased fatty acid chainlength, retarding the leakage rate of molecules from liposomes [37].…”

Section: In Vitro Drug Releasementioning

confidence: 99%

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Comparative Study of PEGylated and Conventional Liposomes as Carriers for Shikonin

Tsermentseli

Kontogiannopoulos

Papageorgiou

et al. 2018

Fluids

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Abstract:Liposomes are considered to be one of the most successful drug delivery systems.They apply nanotechnology to potentiate the therapeutic efficacy and reduce the toxicity of conventional medicines. Shikonin and alkannin, a pair of chiral natural naphthoquinone compounds, derived from Alkanna and Lithospermum species, are widely used due to their various pharmacological activities, mainly wound healing, antioxidant, anti-inflammatory and their recently established antitumor activity. The purpose of this study was to prepare conventional and PEGylated shikonin-loaded liposomal formulations and measure the effects of different lipids and polyethylene glycol (PEG) on parameters related to particle size distribution, the polydispersity index, the zeta potential, drug-loading efficiency and the stability of the prepared formulations. Three types of lipids were assessed (1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) and 1,2-distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DSPG)), separately and in mixtures, forming anionic liposomes with good physicochemical characteristics, high entrapment efficiencies (varying from 56.5 to 89.4%), satisfactory in vitro release profiles and good physical stability. The addition of the negatively charged DSPG lipids to DOPC, led to an increment in the drug's incorporation efficiency and reduced the particle size distribution. Furthermore, the shikonin-loaded PEGylated sample with DOPC/DSPG, demonstrated the most satisfactory characteristics. These findings are considered promising and could be used for further design and improvement of such formulations.

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Section: Liposome Characterizationmentioning

confidence: 99%

Section: In Vitro Drug Releasementioning

confidence: 99%

Comparative Study of PEGylated and Conventional Liposomes as Carriers for Shikonin

Tsermentseli

Kontogiannopoulos

Papageorgiou

et al. 2018

Fluids

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“…Furthermore, delivery systems that allow simultaneous incorporation of antioxidants with different lipophilicities such as ME or liposomes are desirable (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Temperature-Sensitive Microemulsion Gel: An Effective Topical Delivery System for Simultaneous Delivery of Vitamins C and E

et al. 2009

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Abstract. Microemulsions (ME)-nanostructured systems composed of water, oil, and surfactants-have frequently been used in attempts to increase cutaneous drug delivery. The primary objective addressed in this work has been the development of temperature-sensitive microemulsion gel (called gel-like ME), as an effective and safe delivery system suitable for simultaneous topical application of a hydrophilic vitamin C and a lipophilic vitamin E. By changing water content of liquid o/w ME (o/w ME), a gel-like ME with temperature-sensitive rheological properties was formed. The temperature-driven changes in its microstructure were confirmed by rotational rheometry, viscosity measurements, and droplet size determination. The release studies have shown that the vitamins' release at skin temperature from gellike ME were comparable to those from o/w ME and were much faster and more complete than from o/w ME conventionally thickened with polymer (o/w ME carbomer). According to effectiveness in skin delivery of both vitamins, o/w ME was found the most appropriate, followed by gel-like ME and by o/w ME carbomer, indicating that no simple correlation between vitamins release and skin absorption could be found. The cytotoxicity studies revealed good cell viability after exposure to ME and confirmed all tested microemulsions as nonirritant.

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“…A third strategy uses titratable polymers to trigger membrane destabilization. 51 Szoka and coworkers 44 developed a pH-responsive vesicle using PEG-orthoester-distearoylglycerol (POD). At neutral pH, the liposome is stable due to steric repulsions between liposomes due to the PEG.…”

Section: Release By Vesicle Degradationmentioning

confidence: 99%

Mathematical Modeling of Vesicle Drug Delivery Systems 1: Vesicle Formation and Stability Along with Drug Loading and Release

2013

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Colloidal soft matter as drug delivery system

Cited by 133 publications

References 404 publications

Comparative Study of PEGylated and Conventional Liposomes as Carriers for Shikonin

Comparative Study of PEGylated and Conventional Liposomes as Carriers for Shikonin

Temperature-Sensitive Microemulsion Gel: An Effective Topical Delivery System for Simultaneous Delivery of Vitamins C and E

Mathematical Modeling of Vesicle Drug Delivery Systems 1: Vesicle Formation and Stability Along with Drug Loading and Release

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