Colloidal hydrodynamics of biological cells: A frontier spanning two fields

Maheshwari, Akshay J.; Sunol, Alp M.; González, Emma; Endy, Drew; Zia, Roseanna N.

doi:10.1103/physrevfluids.4.110506

Cited by 16 publications

(19 citation statements)

References 144 publications

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“…The ideal order hydrodynamic constitutive relations (9) can be coupled to background sources naturally as 5 In Galilean theories, it is often convenient to work with a different connection, namelỹ…”

Section: Hydrodynamics On Curved Backgroundmentioning

confidence: 99%

“…In this regime, the dynamics is insensitive to most microscopic details and is universally captured by a set of conservation laws. The range of applicability of hydrodynamics spans widely separated scales, in particular those of quantum gravity [1,2], viscous electron flows [3,4], biological fluids [5], and the dynamics of black hole accretion disks [6], to mention only a few. Traditionally, hydrodynamics has been a phenomenological field of study.…”

Section: Introductionmentioning

confidence: 99%

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Effective field theory for hydrodynamics without boosts

Armas

Jain

2021

SciPost Phys.

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We formulate the Schwinger-Keldysh effective field theory of hydrodynamics without boost symmetry. This includes a spacetime covariant formulation of classical hydrodynamics without boosts with an additional conserved particle/charge current coupled to Aristotelian background sources. We find that, up to first order in derivatives, the theory is characterised by the thermodynamic equation of state and a total of 29 independent transport coefficients, in particular, 3 hydrostatic, 9 non-hydrostatic non-dissipative, and 17 dissipative. Furthermore, we study the spectrum of linearised fluctuations around anisotropic equilibrium states with non-vanishing fluid velocity. This analysis reveals a pair of sound modes that propagate at different speeds along and opposite to the fluid flow, one charge diffusion mode, and two distinct shear modes along and perpendicular to the fluid velocity. We present these results in a new hydrodynamic frame that is linearly stable irrespective of the boost symmetry in place. This provides a unified covariant stable approach for simultaneously treating Lorentzian, Galilean, and Lifshitz fluids within an effective field theory framework and sets the stage for future studies of non-relativistic intertwined patterns of symmetry breaking.

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Section: Hydrodynamics On Curved Backgroundmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effective field theory for hydrodynamics without boosts

Armas

Jain

2021

SciPost Phys.

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“…To address these issues, future computational efforts can build upon the spatially explicit models of flow that we have developed here. Integrating from molecular to cell scales is an exciting horizon for cell biologists necessitating an understanding Brownian dynamics, colloidal dynamics and continuum mechanics [43]. Striated muscle boasts a uniquely organized and well-studied system to build models that integrate across these scales.…”

Section: Future Horizonsmentioning

confidence: 99%

Fluid flow in the sarcomere

Malingen

Hood

Lauga

et al. 2021

Archives of Biochemistry and Biophysics

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A highly organized and densely packed lattice of molecular machinery within the sarcomeres of muscle cells powers contraction. Although many of the proteins that drive contraction have been studied extensively, the mechanical impact of fluid shearing within the lattice of molecular machinery has received minimal attention. It was recently proposed that fluid flow augments substrate transport in the sarcomere, however, this analysis used analytical models of fluid flow in the molecular machinery that could not capture its full complexity. By building a finite element model of the sarcomere, we estimate the explicit flow field, and contrast it with analytical models. Our results demonstrate that viscous drag forces on sliding filaments are surprisingly small in contrast to the forces generated by single myosin molecular motors. This model also indicates that the energetic cost of fluid flow through viscous shearing with lattice proteins is likely minimal. The model also highlights a steep velocity gradient between sliding filaments and demonstrates that the maximal radial fluid velocity occurs near the tips of the filaments. To our knowledge, this is the first computational analysis of fluid flow within the highly structured sarcomere.

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“…There are many other examples of colloidal-scale physics implicated in life-essential processes that may benefit from our results; see our recent review (Maheshwari et al. 2019). In terms of non-living systems, the de-mixing behaviour we discovered could be useful in the design of encapsulated micro-reactors and therapeutic vesicles, where spatial segregation can be used to control reactions or delivery.…”

Section: Discussionmentioning

confidence: 81%

“…For example, diffusive transport of biomolecules plays a central role in life-essential processes in biological cells (Maheshwari et al. 2019). One recently demonstrated example is protein synthesis in Escherichia coli ( E. coli ), where changes in the relative abundances of biomolecules of different sizes drives changes in packing fraction and diffusivity of the biomolecules that, in consequence, play a key role in the transport latency associated with protein synthesis rates (Maheshwari et al.…”

Section: Introductionmentioning

confidence: 99%