Colloidal (-)-epigallocatechin-3-gallate vesicular systems for prevention and treatment of skin cancer: A comprehensive experimental study with preclinical investigation

Berries polyphenols: Nano-delivery systems to improve their potential in cancer therapy

“…Application of nanotechnology in the treatment of cancer has gained remarkable attention in the recent years, since utilization of nano-carriers for bioactive molecules, or stabilized solid-drug NPs, may increase solubility, absorption and bioavailability of natural or synthetic bioactive compounds, protect them from premature degradation, and prolong their circulation time in the optimal dose. Additionally, nano-delivery systems improve intracellular penetration, reduce systemic toxicity of both, bioactive compounds and/or co-delivered drugs, and exhibit high differential uptake efficiency in target cells over normal cells [7,[15][16][17][18].…”

“…There is a wide variety of materials that can be used as nano-carriers, such as micelles, biodegradable polymers, drug-polymer polysaccharide conjugates, liposomes/vesicles, cubosomes, organometallic compounds, hydrogels and solid lipid NPs, among others [3,14,[17][18][19]. Nano-delivery systems must be innocuous, stable, non-immunogenic, non-thrombogenic, non-inflammatory, and biodegradable [16,19].…”

“…1) [21][22][23][24]. They offer several advantages, such as biocompatibility, controlled drug delivery and the possibility to immobilize or release both, hydrophilic and lipophilic compounds [18,22]. Hydrophilic polyphenols (e.g.…”

“…Both in vitro and in vivo models have demonstrated that EGCG induced cell death in several types of cancers, such as breast, colon, kidney, brain and leukemia [40,41]. However, it possesses low bioavailability, chemical instability and poor targeting ability, which limits its therapeutic use [18,40]. These disadvantages can be reversed using nanotechnology.…”

Untitled

“…The major cause of photocarcinogenesis is the severe exposure of ultraviolet radiation, which can leading onset of the prevalent forms of skin carcinoma, basal and squamous cell carcinomas, commonly known as nonmelanoma skin cancers 5,6,7 . Ultraviolet radiation is considered as a major factor for the induction of permanent alterations in DNA which leads to several modifications on signaling pathways 8,9 .…”