Colloidal drug probe: Method development and validation for adhesion force measurement using Atomic Force Microscopy

Islam, Nazrul; Tuli, Rinku A.; George, Graeme A.; Dargaville, Tim R.

doi:10.1016/j.apt.2014.06.021

Cited by 11 publications

(10 citation statements)

References 23 publications

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“…A similar impact was also observed for lactose and beclomethasone dipropionate particles (Young et al, 2002). Recent studies by Islam et al (2014) demonstrated the use of a salbutamol sulphate-coated model colloidal probe for comparing the adhesion between hydrophilichydrophilic and hydrophilic-hydrophobic surfaces. They compared the adhesion of polymer, silica and salbutamol sulphatecoated silica microspheres to spin-coated polymer films.…”

Section: Adhesion Measurementssupporting

confidence: 57%

“…Elasticity (Davies et al, 2005;Perkins et al, 2009Perkins et al, , 2007 Deformation (local) Hardness (Masterson and Cao, 2008;Perkins et al, 2009) Degradation during storage or processing (Perkins et al, 2009) Force distance measurements Elastic modulus Elasticity (Davies et al, 2005;Perkins et al, 2009, 2007 Hardness (Masterson and Cao, 2008;Perkins et al, 2009) Adhesion Degradation during storage or processing (Perkins et al, 2009) Crystallinity (Perkins et al, 2007) Particle surface energetics (Davies et al, 2005;Perkins et al, 2009) Chemical surface properties (Hooton et al, 2004) Correlation of surface specific properties (Perkins et al, 2007;Ward et al, 2005) Colloidal probe AFM Adhesion Physical interaction between materials (Beach et al, 2002;Hooton et al, 2004;Rogueda et al, 2011) Chemical interaction between materials (Hooton et al, 2004;Islam et al, 2014;Rogueda et al, 2011) Cohesive adhesive balance (Begat et al, 2004a;Jones et al, 2008a,b) Particle surface energetics (Hooton et al, 2006a) Electrostatic surface properties (Götzinger and Peukert, 2003;Kwek et al, 2011) Triboelectric charging (Kwek et al, 2011) Surface polarity (Kwek et al, 2011) Fig. 1.…”

Section: Phase Imagingmentioning

confidence: 99%

“…After curing, the prepared AFM probe can be immersed into a solution or dispersion for coating purposes ( Fig. 3e and f) using either the micromanipulator or the AFM piezo elements (Islam et al, 2014) to adjust the z-position until the sphere is covered. Islam et al (2014) used the latter method to coat silica microspheres with salbutamol sulphate using commerciallyavailable cantilevers with pre-attached silica beads.…”

Section: Colloidal Probe Afmmentioning

confidence: 99%

“…3e and f) using either the micromanipulator or the AFM piezo elements (Islam et al, 2014) to adjust the z-position until the sphere is covered. Islam et al (2014) used the latter method to coat silica microspheres with salbutamol sulphate using commerciallyavailable cantilevers with pre-attached silica beads. These commercial cantilevers are less susceptible to damage and contamination and benefit from a lower deviation of the spring constant compared to manually prepared probes which is significant for accurate results.…”

Section: Colloidal Probe Afmmentioning

confidence: 99%

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Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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A B S T R A C TInhalation formulations are a popular way of treating the symptoms of respiratory diseases. The active pharmaceutical ingredient (API) is delivered directly to the site of action within the deep lung using an inhalation device such as the dry powder inhaler (DPI).The performance of the formulation and the efficiency of the treatment depend on a number of factors including the forces acting between the components. In DPI formulations these forces are dominated by interparticulate interactions. Research has shown that adhesive and cohesive forces depend on a number of particulate properties such as size, surface roughness, crystallinity, surface energetics and combinations of these. With traditional methods the impact of particulate properties on interparticulate forces could be evaluated by examining the bulk properties. Atomic force microscopy (AFM), however, enables the determination of local surface characteristics and the direct measurement of interparticulate forces using the colloidal probe technique. AFM is considered extremely useful for evaluating the surface topography of a substrate (an API or carrier particle) and even allows the identification of crystal faces, defects and polymorphs from high-resolution images. Additionally, information is given about local mechanical properties of the particles and changes in surface composition and energetics. The assessment of attractive forces between two bodies is possible by using colloidal probe AFM.This review article summarises the application of AFM in DPI formulations while specifically focussing on the colloidal probe technique and the evaluation of interparticulate forces.2015 Elsevier B.V. All rights reserved.

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Section: Adhesion Measurementssupporting

confidence: 57%

Section: Phase Imagingmentioning

confidence: 99%

Section: Colloidal Probe Afmmentioning

confidence: 99%

Section: Colloidal Probe Afmmentioning

confidence: 99%

See 2 more Smart Citations

Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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“…This type of artemisinin crystal-modified AFM probe was used for AFM scratching test in water with a liquid cell. Note that pharmaceutical researchers used the similar drug particle-modified AFM probes, the socalled colloidal drug probes by some, for adhesion studies [23][24][25].…”

Section: Results and Discussion Artemisinin Crystals Artemisinin-modmentioning

confidence: 99%

Marrying medicine and materials: artemisinin (Qinghaosu) particle is soft enough for scratching hard SiC wafer in water

Zhu

Zhang

Gan

et al. 2016

ScienceOpen Research

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Silicon carbide (SiC) single crystals, along with sapphire and silicon, are one of the most important substrates for highbrightness light-emitting diode fabrications. Owing to extremely high hardness (Mohs' scale of 9.5) and chemical inertness, the polishing rate of SiC with conventional chemical mechanical polishing methods is not high, and surface scratches are also inevitable because of using slurry containing hard abrasives such as silica particles. Here artemisinin (Qinghaosu) crystals, very soft molecular solids, were found, for the first time to the best of our knowledge, to effectively polish SiC wafers even in pure water as demonstrated by proof-of-concept scratching experiments using atomic force microscopy. The underlying mechanism is attributed to activated oxidation of SiC by mechanically released reactive ·OH free radicals from the endoperoxide bridges. The preliminary results reported here have important implications for developing novel alternative green and scratch-free polishing methods for hard-brittle substrates including SiC, diamond, and others.

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Nicotine-loaded chitosan nanoparticles for dry powder inhaler (DPI) formulations – Impact of nanoparticle surface charge on powder aerosolization

Wang

George

Islam

2018

Advanced Powder Technology

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Colloidal drug probe: Method development and validation for adhesion force measurement using Atomic Force Microscopy

Cited by 11 publications

References 23 publications

Characterisation of dry powder inhaler formulations using atomic force microscopy

Characterisation of dry powder inhaler formulations using atomic force microscopy

Marrying medicine and materials: artemisinin (Qinghaosu) particle is soft enough for scratching hard SiC wafer in water

Nicotine-loaded chitosan nanoparticles for dry powder inhaler (DPI) formulations – Impact of nanoparticle surface charge on powder aerosolization

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