Colloidal drug delivery system: amplify the ocular delivery

Ameeduzzafar,; Ali, Javed; Fazil, Mohd; Qumbar, Mohd; Khan, Nazia; Ali, Asgar

doi:10.3109/10717544.2014.923065

Cited by 87 publications

(36 citation statements)

References 156 publications

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“…Liposomes are microscopic structures consisting of one or more concentric spheres of lipid bilayers enclosing aqueous compartments. Liposomes have been successfully used to encapsulate lipophilic and hydrophilic compounds (Eroglu et al, 2014;Johal et al, 2014;Ali et al, 2014;El-badry et al, 2014;Fang et al, 2015). In the dermatological field, liposomes were used initially only because of their moisturizing and restoring action.…”

Section: Introductionmentioning

confidence: 99%

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

et al. 2015

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Topical tretinoin is the most commonly used retinoid for acne. However, its irritative potential on the applied area and the barrier properties of the stratum corneum limit its use. The objective of the present study was to formulate tretinoin liposomal gel to obtain a formula with lower skin irritation potential and greater clinical effect. A statistical 2 4 factorial design was adopted. Sixteen formulae prepared and were properly evaluated. A candidate formula (F13G) prepared with 0.025% tretinoin, phospholipid-cholesterol-dicetylphosphate (9:1:0.01) and incorporated in 1% carbopol gel was selected for skin irritation test. Clinical study was conducted on acne patients and compared to marketed product. All liposomes formulations were spherical in shape. The addition of cholesterol in the film hydration method significantly decreased the vesicle size, and increased the percentage of incorporation efficiency at (p50.05). The presence of dicetylphosphate significantly increased drug release but did not affect the percentage of incorporation efficiency and vesicle size. The results of the clinical study in acne patients revealed that F13G showed significantly higher efficacy when compared to marketed product (p50.05).

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Section: Introductionmentioning

confidence: 99%

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

et al. 2015

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“…An ocular formulation should release the drug by bypassing the protective barriers of the eye without damaging the tissues (Ali et al, 2016). Ocular drug delivery systems generally have low bioavailability, limited absorption in the intraocular area due to blinking reflex, less eye capacity, nasolacrimal drainage, and the corneal and conjunctival epithelial barriers which ultimately reduces the retention time of drug molecules in the eyes (Kaur et al, 2012).…”

Section: Ocular Deliverymentioning

confidence: 99%

Proniosomes derived niosomes: recent advancements in drug delivery and targeting

et al. 2017

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Vesicular drug delivery systems have gained wide attention in the field of nanotechnology. Among them proniosomes become the superior over other vesicular carriers. Proniosomes are dry formulations of water soluble nonionic surfactant coated carrier system which immediately forms niosomes upon hydration. They have the capability to overcome the instability problems associated with niosomes and liposomes and have the potential to improve solubility, bioavailability, and absorption of various drugs. Furthermore, they offer versatile drug delivery concept for enormous number of hydrophilic and hydrophobic drugs. They have the potential to deliver drugs effectively through different routes at specific site of action to achieve controlled release action and reduce toxic effects associated with drugs. This review discusses the general preparation techniques of proniosomes and mainly focus on the applications of proniosomes in drug delivery and targeting. Moreover, this review demonstrates critical appraisal of the literature for proniosomes. Additionally, this review extensively explains the potential of proniosomes in delivering drugs via different routes, such as oral, parenteral, dermal and transdermal, ocular, oral mucosal, vaginal, pulmonary, and intranasal. Finally, the comparison of proniosomes with niosomes manifests the clear distinction between them. Moreover, proniosomes need to be explored for proteins and peptide delivery and in the field of nutraceuticals and develop pilot plant scale up studies to investigate them in industrial set up. ARTICLE HISTORY

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“…However, ERT is not available for all MPS, and it is not curative. Although ERT can be very effective at treating the systemic disease, classical lysosomal enzymes are not capable of crossing the BBB or the BRB in the eye [56,61].…”

Section: Enzyme Delivery For Mps and Nanotechnologymentioning

confidence: 99%

Nanotechnology applied to treatment of mucopolysaccharidoses

Schuh

Baldo

Teixeira

2016

Expert Opinion on Drug Delivery

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Mucopolysaccharidoses (MPS) are genetic disorders caused by the accumulation of glycosaminoglycans due to deficiencies in the lysosomal enzymes responsible for their catabolism. Current treatments are not fully effective and are not available for all MPS types. Accordingly, researchers have tested novel therapies for MPS, including nanotechnology-based enzyme delivery systems and gene therapy. In this review, we aim to analyze some of the approaches involving nanotechnology as alternative treatments for MPS. Areas covered: We analyze nanotechnology-based systems, focusing on the biomaterials, such as polymers and lipids, that comprise these nanostructures, and we have highlighted studies that describe their use as enzyme and gene delivery systems for the treatment of MPS diseases. Expert opinion: Some protocols, such as the use of polymer-based systems or nanostructured carriers associated with enzymes and nanotechnology-based carriers for gene therapy, along with combined approaches, seem to be the future of MPS therapy.

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Colloidal drug delivery system: amplify the ocular delivery

Abstract: Form the basis of literature review, it has been found that the novel delivery system have greater impact to maximize ocular drug absorption, and minimize systemic absorption and side effects.

Cited by 87 publications

References 156 publications

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

Proniosomes derived niosomes: recent advancements in drug delivery and targeting

Nanotechnology applied to treatment of mucopolysaccharidoses

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