Colloidal characterization of CuO nanoparticles in biological and environmental media

Ortelli, Simona; Costa, Anna Luisa; Blosi, Magda; Brunelli, Andrea; Badetti, Elena; Bonetto, Alessandro; Hristozov, Danail; Marcomini, Antonio

doi:10.1039/c6en00601a

Cited by 31 publications

(26 citation statements)

References 76 publications

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“…Commercial CuO nanopowder (called CuO-NOAA) were provided by PlasmaChem GmbH (Germany). These NOAA were previously characterized by Ortelli et al (2017). They were spherical with primary average diameter of 12 ± 8 nm (TEM size), a specific surface area (BET) of 47 m 2 .g -1 , an average hydrodynamic diameter in their stock suspension at 140 ± 5nm, and an isoelectric point at pH 10.3 11 .…”

Section: Cuo-noaa and Acrylic Paintmentioning

confidence: 99%

“…These NOAA were previously characterized by Ortelli et al (2017). They were spherical with primary average diameter of 12 ± 8 nm (TEM size), a specific surface area (BET) of 47 m 2 .g -1 , an average hydrodynamic diameter in their stock suspension at 140 ± 5nm, and an isoelectric point at pH 10.3 11 . These NOAA were incorporated in acrylic paints serving as reference compounds for wood preservative coating.…”

Section: Cuo-noaa and Acrylic Paintmentioning

confidence: 99%

“…acrylic paint) are applied to the wood, the cupric ions react with carboxylic and phenolic groups from cellulose, hemicellulose and lignin. This leads to the homogenous distribution of the ions in the wood cells, including penetration through cell wall voids 11 which enhance the bactericidal and antifungal properties. However, at different stages of their value chain all these nano-based coatings are likely to release NOAA 6 in the environment.…”

Section: Introductionmentioning

confidence: 99%

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Environmental exposure of a simulated pond ecosystem to a CuO nanoparticle-based wood stain throughout its life cycle

Liu

Brousset

Scifo

et al. 2018

Environ. Sci.: Nano

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Indoor aquatic mesocosms were used to assess the behavior of fragmented products of a wood stain containing CuO nanoparticles in a simulated pond ecosytem for 1 month. Byproducts of degradation containing Cu are likely to be released during the use and end-of-life of this wood stain. Over two months, a pond ecosystem was mimicked in 60 L tanks and exposed in environmentally relevant conditions to fragmented products of CuO nanoparticle-based wood stain or pristine CuO nanoparticles. Cu (bio)transformation and (bio)distribution within different environmental compartments (e.g. water, sediments, benthic grazers) were carefully analyzed. Because of the presence of the stain matrix, CuO nanoparticles contained in fragmented products were less bio-physical-chemically transformed (dissolution, complexation) with respect to pristine nanoparticles. After 28 days, only 1% of the Cu injected following fragmented product exposure remained in the water column (0.08 µg.L -1 ), against 10% for the pristine CuO nanoparticles (2.67 µg.L -1 ). Among these ~10%, ~51% were dissolved Cu species (1.35 µg.L -1 ). These results are discussed with respect to the ecological compartments in which they accumulated, and to the dose to which aquatic organisms with distinct life traits were exposed.

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Section: Cuo-noaa and Acrylic Paintmentioning

confidence: 99%

Section: Cuo-noaa and Acrylic Paintmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Environmental exposure of a simulated pond ecosystem to a CuO nanoparticle-based wood stain throughout its life cycle

Liu

Brousset

Scifo

et al. 2018

Environ. Sci.: Nano

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“…However, at several levels there is high complexity associated with the hazard assessment of NBM, both for human risks as well as for the environment [ 21 , 22 ]. Common issues are dealing with the physicochemical identity of the NBMs, the existence of different nanoforms and their transformations in physiological and environmental media (e.g., biocorona formation, weathering/ageing) [ 23 , 24 , 25 ]. In addition, it can be questioned which are the most relevant biomarkers for NBM hazard testing and whether they are currently adequately addressed in the Organisation for Economic Co-operation and Development (OECD) guidelines used for regulatory purposes.…”

Section: The Biorima Risk Management Frameworkmentioning

confidence: 99%

Risk Management Framework for Nano-Biomaterials Used in Medical Devices and Advanced Therapy Medicinal Products

et al. 2020

Self Cite

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The convergence of nanotechnology and biotechnology has led to substantial advancements in nano-biomaterials (NBMs) used in medical devices (MD) and advanced therapy medicinal products (ATMP). However, there are concerns that applications of NBMs for medical diagnostics, therapeutics and regenerative medicine could also pose health and/or environmental risks since the current understanding of their safety is incomplete. A scientific strategy is therefore needed to assess all risks emerging along the life cycles of these products. To address this need, an overarching risk management framework (RMF) for NBMs used in MD and ATMP is presented in this paper, as a result of a collaborative effort of a team of experts within the EU Project BIORIMA and with relevant inputs from external stakeholders. The framework, in line with current regulatory requirements, is designed according to state-of-the-art approaches to risk assessment and management of both nanomaterials and biomaterials. The collection/generation of data for NBMs safety assessment is based on innovative integrated approaches to testing and assessment (IATA). The framework can support stakeholders (e.g., manufacturers, regulators, consultants) in systematically assessing not only patient safety but also occupational (including healthcare workers) and environmental risks along the life cycle of MD and ATMP. The outputs of the framework enable the user to identify suitable safe(r)-by-design alternatives and/or risk management measures and to compare the risks of NBMs to their (clinical) benefits, based on efficacy, quality and cost criteria, in order to inform robust risk management decision-making.

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“…However, when nanomaterials emulsify in a gelatinous substance or suspend in a liquid, they tend to migrate from the mixture into the surrounding environment (Westesen et al 1997). These embedded nanoparticles have the potential to release from products and transform under environmental conditions (Adegboyega et al 2014;Garner and Keller 2014;Amde et al 2017;Joo and Zhao 2017;Ortelli et al 2017;Zhang et al 2018;Simeone et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Copper, silver, and titania nanoparticles do not release ions under anoxic conditions and release only minute ion levels under oxic conditions in water: Evidence for the low toxicity of nanoparticles

et al. 2020

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It is widely assumed that the discharge of nanoparticles into the environment may cause adverse effects on organisms. Nonetheless, so far most nanoparticles have demonstrated little to no observed hazards in multiple biological test systems. It is not until nanoparticles undergo transformations, e.g., release of metal ions, that most environmental toxicities are induced, yet the ionization of nanoparticles in natural oxic and anoxic conditions is poorly known. We hypothesized that in anaerobic conditions, where oxidation is absent or limited, metal nanoparticles should not release metal ions. We investigated the transformation of three commercially produced materials, i.e., copper nanoparticles, silver nanoparticles, and titania nanocrystals with an average particle size of 50 nm. The nanoparticles were subjected to different environmental conditions including oxic/anoxic suspension, incubation with natural organic matter, and pH gradient, then subsequently analyzed for zeta potential, hydrodynamic diameter, concentration of released metal ions, and generation of reactive oxygen species. Transmission electron microscopy was used to assess morphological changes. Under oxic conditions, results show that only 9.4 μg/mL of copper ions and 6.9 μg/mL of silver ions were released from nanoparticles, when continuously stirred over 48 h. These levels are low compared to levels found in natural media. Moreover, under anoxic conditions, an insignificant amount of copper ions of 0.9 μg/mL and silver ions, of 0.2 μg/mL, were released. For titania nanoparticle, less than 0.05 μg/ mL ions were released under either oxic or anoxic conditions. Overall, our findings reveal the absence of ion release under anoxic conditions, and the very low levels of ion released under oxic conditions. As a consequence, the toxicity of Cu, Ag, and Ti nanoparticles should be very low in natural media.

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Colloidal characterization of CuO nanoparticles in biological and environmental media

Cited by 31 publications

References 76 publications

Environmental exposure of a simulated pond ecosystem to a CuO nanoparticle-based wood stain throughout its life cycle

Environmental exposure of a simulated pond ecosystem to a CuO nanoparticle-based wood stain throughout its life cycle

Risk Management Framework for Nano-Biomaterials Used in Medical Devices and Advanced Therapy Medicinal Products

Copper, silver, and titania nanoparticles do not release ions under anoxic conditions and release only minute ion levels under oxic conditions in water: Evidence for the low toxicity of nanoparticles

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