Colloidal astaxanthin: Preparation, characterisation and bioavailability evaluation

Anarjan, Navideh; Tan, Chin Ping; Nehdi, Imededdine Arbi; Ling, Tau Chuan

doi:10.1016/j.foodchem.2012.05.091

Cited by 89 publications

(68 citation statements)

References 27 publications

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“…5). Although some crystallities can be observed for produced astaxanthin nanodispersions, these nanoparticles are more amorphous than microparticles of astaxanthin (astaxanthin powder), which can be confirmed by the results of XRD graphs (Anarjan, Tan, Nehdi, & Ling, 2012). These results are in good agreement with particle size analyzing findings.…”

Section: Morphologysupporting

confidence: 83%

Developing a three component stabilizer system for producing astaxanthin nanodispersions

Anarjan

Tan

2013

Food Hydrocolloids

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a b s t r a c tAstaxanthin nanodispersions were prepared using Polysorbate 20 (PS20), sodium caseinate (SC) and gum Arabic (GA), solely or in combinations, as stabilizer system, through a solvent-diffusion process. The interactions among these three surface active compounds, in the formation, physicochemical and stability characterization of produced nanodispersions were studied by applying a simplex centroid mixture design. Quadratic or special cubic regression models were fitted for variations of all studied responses as function of significant (p < 0.05) interaction effects between stabilizer components' proportions, with acceptable determination coefficients (>0.70). Multiple-response optimization predicted that by using 29% (w/w) PS20, 6% (w/w) GA and 65% (w/w) SC as a three component stabilizer system, an astaxanthin nanodispersion could be produced with the most desirable physicochemical characteristics and highest physicochemical stability. At this optimum stabilizer components proportions, the corresponding predicted response values for mean particle size, polydispersity index (PDI) and total astaxanthin loss were predicted to be 114.6 nm, 0.261 and 680 mg/L, respectively. The optimum astaxanthin nanodispersions also showed 2.06% and 1.05% particle size growth at 25 C and 5 C, 4.56% and 1.29% PDI growth at 25 C and 5 C, and 20% (w/w) astaxanthin loss at 25 C after 8 weeks of storage. The absence of significant (p > 0.05) differences between the experimental and predicted values of the response variables confirmed the adequacy of the fitted models.

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Section: Morphologysupporting

confidence: 83%

Developing a three component stabilizer system for producing astaxanthin nanodispersions

Anarjan

Tan

2013

Food Hydrocolloids

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“…Very small particles may also be directly transported across the epithelial cell layer by paracellular or transcellular mechanisms. 16 Therefore, the greater cellular uptake of samples A and D can be related to their smaller particle size. The greater astaxanthin concentration in sample D caused its relatively high cellular uptake (compared with sample A), as astaxanthin concentration was also a crucial parameter on cellular uptake in bioactive-loaded dispersion system.…”

Section: Resultsmentioning

confidence: 98%

“…The negative effect of particle size on cellular uptake in bioactive-loaded emulsion/dispersion systems has been demonstrated by previous researchers. 4,[14][15][16] Small droplets have a large surface area so can be digested more rapidly and absorbed more easily. Moreover, smaller particles can penetrate easily into the mucous layer coating epithelial cells in the small intestine and bring them closer to the site of absorption.…”

Section: Resultsmentioning

confidence: 99%

Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique

Anarjan¹,

Jafarizadeh‐Malmiri²,

Nehdi³

et al. 2015

IJN

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Nanodispersion systems allow incorporation of lipophilic bioactives, such as astaxanthin (a fat soluble carotenoid) into aqueous systems, which can improve their solubility, bioavailability, and stability, and widen their uses in water-based pharmaceutical and food products. In this study, response surface methodology was used to investigate the influences of homogenization time (0.5–20 minutes) and speed (1,000–9,000 rpm) in the formation of astaxanthin nanodispersions via the solvent-diffusion process. The product was characterized for particle size and astaxanthin concentration using laser diffraction particle size analysis and high performance liquid chromatography, respectively. Relatively high determination coefficients (ranging from 0.896 to 0.969) were obtained for all suggested polynomial regression models. The overall optimal homogenization conditions were determined by multiple response optimization analysis to be 6,000 rpm for 7 minutes. In vitro cellular uptake of astaxanthin from the suggested individual and multiple optimized astaxanthin nanodispersions was also evaluated. The cellular uptake of astaxanthin was found to be considerably increased (by more than five times) as it became incorporated into optimum nanodispersion systems. The lack of a significant difference between predicted and experimental values confirms the suitability of the regression equations connecting the response variables studied to the independent parameters.

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“…Fuente: GRAS La estéreoespecifidad de las moléculas está directamente relacionada con su actividad biológica, por lo que, los carotenoides naturales son más biodisponibles y presentan mayor efectividad (BioNutrition, 2008). Por sus características estructurales y las posiciones 4 y 4' aumentan la capacidad antioxidante aún más que las reportadas por otros carotenos tiene la capacidad de capturar los radiales libres (Guerin, Huntley, & Olaizola, 2003) Por su característica hidrofóbica es común encontrarla en algunos animales y crustáceos ligada a las proteínas y lípidos presentes en la carne, por lo que en el momento de la cocción la molécula puede sufrir modificaciones y alteraciones biológicas (Sila, et al, 2015;Rao, et al, 2013;Anarjan, et al, 2012).…”

Section: Tabla 1 Características De La Astaxantinaunclassified

Obtención y caracterización de astaxantina de la microalga Haematococcus pluvialis

Astroc

Reyes

Buitrago³

et al. 2016

RevistaUGCiencia

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La Astaxantina es un carotenoide perteneciente a la familia de las xantofilas por la presencia de oxígeno en su estructura química. Su uso se ha difundido en la industria farmacéutica y pecuaria, siendo la primera la que más potencial presenta debido a su uso como antioxidante. Existen diferentes fuentes para la obtención de astaxantina, sin embargo; en los últimos años ha tomado gran relevancia la obtención de esta biomolécula a partir de microorganismos fotosintéticos como las microalgas, las cuales pueden producir diferentes metabolitos aprovechando la energía solar y capturando el CO2 de la atmósfera. Se ha encontrado que la microalga Haematococcus pluvialis es una de las microalgas que mayor potencial presenta en la producción de astaxantina. Esta producción se realiza bajo condiciones de estrés por represión de nutrientes, intensidades de luz, entre otros. Debido a la importancia que reviste la astaxantina y su aprovechamiento a nivel industrial se han evaluado diferentes métodos para su extracción y cuantificación tales como: extracción con solvente, con fluidos supercríticos, cuantificación por HPLC con fase reversa acoplada a espectrofotometría de masas, siendo éstos los más desarrollados para este tipo biomolécula, la cual se ha cuantificado en el espectro UV/Visible por las características propias de la molécula, como son sus enlaces conjugados. Sin embargo, al tratarse de un carotenoide cada una de las metodologías de extracción y cuantificación deben ser evaluadas cuidadosamente con el fin de que ésta no sea degradada. El presente artículo presenta una breve descripción de los métodos más usado en la extracción y cuantificación de la astaxantina de H. pluvialis y las perspectivas de uso de esta biomolécula.

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Colloidal astaxanthin: Preparation, characterisation and bioavailability evaluation

Cited by 89 publications

References 27 publications

Developing a three component stabilizer system for producing astaxanthin nanodispersions

Developing a three component stabilizer system for producing astaxanthin nanodispersions

Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique

Obtención y caracterización de astaxantina de la microalga Haematococcus pluvialis

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Colloidal astaxanthin: Preparation, characterisation and bioavailability evaluation

Cited by 89 publications

References 27 publications

Developing a three component stabilizer system for producing astaxanthin nanodispersions

Developing a three component stabilizer system for producing astaxanthin nanodispersions

Effects of homogenization process&nbsp;parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique

Obtención y caracterización de astaxantina de la microalga Haematococcus pluvialis

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Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique