Colloid oncotic pressure and total protein changes in horses during anesthesia fluid therapy

Boscán, Pedro; Watson, Zara; Farver, TB; Steffey, EP

doi:10.1111/j.1467-2995.2005.00232a_33.x

Cited by 2 publications

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“…There was also an increase in mucosal and serosal oedema grade compared to NORM in the SI during REPER which may have also been a result of manipulation, biopsy, a systemic response to colonic injury, or the consequence of anaesthetic management including large-volume i.v. fluid administration (Boscan et al 2004). The increase in SI oedema grade compared to NORM during REPER supports the idea that factors associated with surgery and anaesthesia affected the SI and could also have affected IGF-R mRNA expression.…”

Section: Discussionsupporting

confidence: 66%

Growth factor and receptor mRNA expression in the intestine of horses with large colon volvulus: a pilot study

Southwood

Lindermann

Zarucco

et al. 2006

Equine Veterinary Journal

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Section: Discussionsupporting

confidence: 66%

Growth factor and receptor mRNA expression in the intestine of horses with large colon volvulus: a pilot study

Southwood

Lindermann

Zarucco

et al. 2006

Equine Veterinary Journal

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Blood acid-base status in impala (Aepyceros melampus) immobilised and maintained under total intravenous anaesthesia using two different drug protocols

Zeiler

Meyer

2017

BMC Vet Res

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BackgroundIn mammals, homeostasis and survival are dependent on effective trans-membrane movement of ions and enzyme function, which are labile to extreme acid-base changes, but operate efficiently within a narrow regulated pH range. Research in patients demonstrating a pH shifts outside the narrow regulated range decreased the cardiac output and systemic vascular resistance and altered the oxygen binding to haemoglobin. These cardiopulmonary observations may be applicable to the risks associated with anaesthesia and performance of wildlife ungulates on game farms. The aim of this study was to compare blood pH changes over time in impala immobilised and anaesthetised with two different drug protocols (P-TMP - immobilisation: thiafentanil-medetomidine; maintenance: propofol-ketamine-medetomidine; P-EME – immobilisation: etorphine-medetomidine; maintenance: etorphine-ketamine-medetomidine). Additionally, we discuss the resultant blood pH using both the Henderson-Hasselbalch and the Stewart approaches. Two data collection time points were defined, Time1 before maintenance of general anaesthesia and Time 2 at end of maintenance of general anaesthesia. We hypothesise that blood pH would not be different between drug protocols and would not change over time.ResultsSignificant differences were detected over time but not between the two drug protocols. Overall, the blood pH decreased over time from 7.37 ± 0.04 to 7.31 ± 0.05 (p = 0.001). Overall, over time arterial partial pressure of carbon dioxide changed from 51.3 ± 7.5 mmHg to 72.6 ± 12.4 mmHg (p < 0.001); strong ion difference from 44.6 ± 2.4 mEq/L to 46.9 ± 3.1 mEq/L (p < 0.001); anion gap from 15.0 ± 3.1 mEq/L to 10.9 ± 2.2 mEq/L (p < 0.001); and total weak acids from 16.1 ± 1.2 mmol/L to 14.0 ± 1.1 mmol/L (p < 0.001). The bicarbonate changed from 29.6 ± 2.7 mEq/L to 36.0 ± 4.1 mEq/L (p < 0.001); and lactate changed from 2.9 ± 1.5 mEq/L to 0.3 ± 0.03 mEq/L (p < 0.001) over time.ConclusionsThe profound increase in the partial pressure of carbon dioxide that worsened during the total intravenous anaesthesia in both protocols initiated a substantial metabolic compensatory response to prevent severe acidaemia. This compensation resulted in a clinically acceptable mild acidaemic state, which worsened over time but not between the protocols, in healthy impala. However, these important compensatory mechanisms require normal physiological function and therefore when immobilising ill or anorexic wild ungulates their acid-base status should be carefully assessed.

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Colloid oncotic pressure and total protein changes in horses during anesthesia fluid therapy

Cited by 2 publications

References 0 publications

Growth factor and receptor mRNA expression in the intestine of horses with large colon volvulus: a pilot study

Growth factor and receptor mRNA expression in the intestine of horses with large colon volvulus: a pilot study

Blood acid-base status in impala (Aepyceros melampus) immobilised and maintained under total intravenous anaesthesia using two different drug protocols

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