Collisions of organic ions at surfaces

Cooks, R. Graham; Jo, Sung‐Chan; Green, Jason

doi:10.1016/j.apsusc.2004.03.017

Cited by 19 publications

(12 citation statements)

References 64 publications

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“…The biopolymer solution was infused with an infusion rate at 2 mL min -1 . The basic reagents such as ammonia were dissolved in water to create a series of concentrations (pH [8][9][10][11][12][13][14] and then infused to channel 2, which served to spray the solution directly into the ESI beam generated from channel 1 (Figure 1). Basic liquid reagents such as 1,5-diazabicyclo[4,3,0]-non-5-ene was directly infused to generate the reagent spray.…”

Section: Reagentsmentioning

confidence: 99%

“…Additionally, studies of biopolymer ions with different charge states, especially singly charged ions in the gas phase, might help to better understand the physico-chemical and/or biological properties (for example, conformation 8 ) of the molecules. It might also be helpful to conserve a high bioactivity in soft landing experiments 9,10 when singly charged ions rather than Manipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source multiply charged ions are used. Intrinsically, charge reduction is compatible with any type of mass analyzer, subject only to mass range limitations.…”

Section: Introductionmentioning

confidence: 99%

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Manipulation of Charge States of Biopolymer Ions by Atmospheric Pressure Ion/Molecule Reactions Implemented in an Extractive Electrospray Ionization Source

Chen

Touboul

Jecklin

et al. 2007

Eur J Mass Spectrom (Chichester)

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A home-made extractive electrospray ionization source is coupled to an linear quadrupole ion trap mass spectrometer to investigate ion/molecule reactions of biopolymers at ambient pressure. Multiply charged biopolymers such as peptides and proteins generated in an electrospray are easily reduced to a low charge state by the atmospheric pressure ion/molecule reactions occurring between the multiply charged ions and a strong basic reagent sprayed in neutral form into the electrospray plume. The charge state of the biopolymer ions can be manipulated by controlling the amount of the basic reagent. The production of biopolymer ions with low charge states results in a substantial improvement of sensitivity and reduced spectral congestion in ESI-MS. This is of importance for biopolymer mixture analysis and could have promising applications in proteomics.

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Section: Reagentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Manipulation of Charge States of Biopolymer Ions by Atmospheric Pressure Ion/Molecule Reactions Implemented in an Extractive Electrospray Ionization Source

Chen

Touboul

Jecklin

et al. 2007

Eur J Mass Spectrom (Chichester)

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“…Direct landing on unmodified surfaces has shown success; however in some cases there have been results that show possible hydrocarbon contamination on plain metal surfaces such as stainless steel. 71 Gold modified with a SAM of alkanethiol chains is a popular substrate due to the array of functionalization that can take place on the surface. 72 Wysocki and coworkers showed this in the early 1990s, when comparing an unmodified vs. modified gold surface.…”

Section: Surface Preparationmentioning

confidence: 99%

Soft-landing preparative mass spectrometry

Verbeck

Hoffmann

Walton

2012

Analyst

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Preparative mass spectrometry has become a diverse field that covers the spectrum of kinetic energy deposition. Of these methods, soft-landing mass spectrometry has many fundamental properties, which make it an advantageous technique for ion isolation and deposition. Its definition implies the preservation of ionic structural integrity after landing, which ensures the structure-function relationship of a molecule remains intact. Here the focus is on the instruments and applications of studying ion-surface landing in the hyperthermal and thermal kinetic energy regimes. Soft-landing preparative mass spectrometry covers the breadth of mass spectrometric ionization sources, instrumental configurations, and molecular families. Due to the diverse nature of soft landing, and to maximize readability, this review has been organized according to instrumental considerations and molecular families, with a discussion of theoretical work at the end.

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“…Thus, ionization of the analyte can be considered as originating from the impact of the charged droplets on the surface. The general DESI mechanism can be schematized as follow [5][6][7]:…”

Section: Desorption Electrospray Ionization (Desi)mentioning

confidence: 99%

Aspects of the Role of Surfaces in Ionization Processes

Crotti¹,

Traldi²

2009

CCHTS

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The operating principles and some applications of atmospheric pressure desorption electrospray ionization (DESI) and surface activated chemical ionization (SACI) methods are described in detail. The former technique allows one to obtain information on the chemical composition (in terms of organic compounds) present on a surface of interest. The latter, SACI, provides chemical information as a result of the interaction of a vaporised solution of the analyte with a metallic surface. Both techniques typically lead to the production of abundant protonated molecules. The data available in the literature indicate that both DESI and SACI are highly promising techniques with the former giving to mass spectrometry new application fields, and the latter an increasing sensitivity and a lowering of chemical noise that, in the case of biological samples, represent a weak point in many analytical measurements.

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Collisions of organic ions at surfaces

Cited by 19 publications

References 64 publications

Manipulation of Charge States of Biopolymer Ions by Atmospheric Pressure Ion/Molecule Reactions Implemented in an Extractive Electrospray Ionization Source

Manipulation of Charge States of Biopolymer Ions by Atmospheric Pressure Ion/Molecule Reactions Implemented in an Extractive Electrospray Ionization Source

Soft-landing preparative mass spectrometry

Aspects of the Role of Surfaces in Ionization Processes

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