Collision tumour of extramammary Paget disease and melanoma

A Rare Collison of Vulvar Melanoma and Extramammary Paget Disease: Case Report and Review of the Literature

“…EMPD was noninvasive in most cases, with the sole invasive EMPD case associated with metastasis to other organs. This report by Mae et al 8 was also the only collision of EMPD and MM in both the primary and metastatic sites (inguinal lymph node). Only 2 patients had a history of cancer.…”

“…In cases with complete clinical descriptions of skin lesions, MM corresponded to areas that were darkly pigmented while EMPD corresponded to erythematous areas beyond normal-appearing skin. [7][8][9] Histologic features useful in identifying the pagetoid cells of EMPD from MM relied on distinct cytoplasmic features such as presence of blue mucin, vacuolization, and clear cytoplasm without melanin. IHC stains ultimately provided confirmation of the presence of 2 tumors.…”

“…A search on PubMed for “(melanoma) AND (extramammary Paget disease)” within the English literature found 5 instances of MM and EMPD occurring within the same lesion (“collision tumors”) 6–10 and 3 instances of them occurring at different anatomic regions (“double tumors”) 6,11,12 (Table 1). Our report would be the sixth example of a collision tumor of MM and EMPD.…”

Extramammärer Morbus Paget und Melanom: Zwei Fälle zweifacher Krebserkrankungen

“…Ein Zusammenhang des EMP mit zugrunde liegenden in-situ- oder invasiven Neoplasien ist umfassend belegt [1, 2]. Über kutane maligne Melanome (MM) in Verbindung mit EMP liegen jedoch erst wenige Fallberichte vor, und zwar als Kollisionstumoren [3-5] oder gleichzeitig an unterschiedlichen Lokalisationen auftretend, mit primärem MM [6] oder rezidivierendem MM [7]. Im vorliegenden Fallbericht werden zwei solche Fälle von zweifacher maligner Erkrankung vorgestellt; ein Patient mit einem Kollisionstumor und eine Patientin mit zwei Neoplasien unterschiedlicher Lokalisation.…”

Extramammary Paget’s Disease and Melanoma: 2 Cases of Double Cancers

“…A relationship between EMPD and underlying in situ or invasive neoplasms is well known [1, 2]. However, only a few cases of cutaneous malignant melanoma (MM) and EMPD have been reported to date: as collision tumors [3-5], at separate sites simultaneously with primary MM [6], or with relapsing MM [7]. In this case report 2 cases of such double cancers are presented; one patient with a collision tumor, the other at separate sites.…”