Collision Tumor of the Ovary

Schoolmeester, J. Kenneth; Keeney, Gary L.

doi:10.1097/pgp.0b013e31824d354f

Cited by 15 publications

(5 citation statements)

References 11 publications

(11 reference statements)

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“…A review of the literature identified 19 cases of ovarian epithelial neoplasms, ranging from benign to malignant, that were combined with an AGCT 12–30 . Of the 20 reported cases (including our case), 13 presented with a grossly evident nodule or mass-like area of granulosa cell proliferation, while 7 cases did not display a visible granulosa cell mass (Table 1).…”

Section: Discussionmentioning

confidence: 94%

Composite FOXL2 Mutation-positive Adult Granulosa Cell Tumor and Serous Borderline Tumor of the Ovary

Guerrieri

Hudacko

Anderson

2022

International Journal of Gynecological Pathology

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We report a case of a cystic ovarian neoplasm in a 76-yr-old female composed of 2 distinct and intimately associated components: a macrocystic adult granulosa cell tumor (AGCT) and a serous borderline tumor. The granulosa cell nature of the tumor was confirmed with positive immunohistochemical staining for inhibin, calretinin, and WT1, while the neoplastic nature of the granulosa cell proliferation was supported by the presence of a point mutation of the FOXL2 gene. A review of 19 previously reported mixed AGCT and epithelial neoplasms of the ovary is included. Of the eight mixed AGCT and epithelial tumors, including our case, that were tested for FOXL2 mutation, 4 of the 5 mutation-positive cases were notable for demonstrating a macroscopically visible nodule or mass of AGCT at the time of gross examination, while 2 of the 3 mutation-negative cases lacked a mass-producing granulosa cell component. This feature by itself may be sufficient to predict the true neoplastic nature of the granulosa cell proliferation. This is the first reported case of a composite neoplastic AGCT and serous borderline tumor. We also discuss the current histogenetic models for these rare mixed AGCT and epithelial tumors.

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Section: Discussionmentioning

confidence: 94%

Composite FOXL2 Mutation-positive Adult Granulosa Cell Tumor and Serous Borderline Tumor of the Ovary

Guerrieri

Hudacko

Anderson

2022

International Journal of Gynecological Pathology

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“…9 The histological findings were described for all 45 ovarian collision tumors, with 14 combinations of teratomas and cystadenomas, 9 teratomas and cystadenocarcinomas, 12 cystadenomas/ cystadenocarcinomas and other tumors, 6 teratomas and other tumors, and 4 other extremely rare combinations. 4,[10][11][12] Diagnostic imaging was shown for 25 tumors, including 17 MRI, 3 CT, and 5 ultrasonography scans. 2,5,6,13 The rare imaging reports of ovarian collision tumors may reflect insufficient recognition of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, there have been 25 reports on 45 ovarian collision tumors in English language literature, 1–6,9–25 since YM Bhende reported a Brenner tumor in the wall of a serous cystadenoma in 1947 9 . The histological findings were described for all 45 ovarian collision tumors, with 14 combinations of teratomas and cystadenomas, 9 teratomas and cystadenocarcinomas, 12 cystadenomas/cystadenocarcinomas and other tumors, 6 teratomas and other tumors, and 4 other extremely rare combinations 4,10–12 . Diagnostic imaging was shown for 25 tumors, including 17 MRI, 3 CT, and 5 ultrasonography scans 2,5,6,13 .…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Findings andO‐RADSMalignancy Risk Stratification of Ovarian Collision Tumors

Guo

Zhou

Zhao

et al. 2021

J of Ultrasound Medicine

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Objectives-To describe the ultrasonographic signs of ovarian collision tumors and evaluate the malignancy risk using the O-RADS system.Methods-This was a retrospective analysis of 25 ovarian collision tumors from 8739 patients between May 2010 and January 2020. All clinical characteristics, ultrasound images, and histological findings were collected and analyzed. Using the O-RADS lexicon descriptors, the O-RADS score was determined by two senior doctors. Lesions with O-RADS scores of 1 to 3 were classified as benign tumors, and lesions with O-RADS scores of 4 to 5 were classified as malignant tumors.Results-The mean age of the 25 patients was 30.4 years. Histological findings showed that all tumors were a combination of mature cystic teratomas and cystadenomas/cystadenocarcinomas. There were 11 benign tumors of O-RADS 2 or 3, including 3 uniocular cysts, 3 dermoid cysts, and 5 dermoid cysts with an anechoic fluid cavity. There were 12 benign tumors of O-RADS 4, including 3 uniocular-multilocular cysts with solid components, 2 multilocular cysts with irregular walls, and 8 multilocular cysts with dermoid sacs. One borderline tumor of O-RADS 4 was a multilocular cyst with irregular septation. One malignant tumor of O-RADS 5 was a multilocular cystic tumor with solid components and ascites.Conclusions-The most common ovarian collision tumor was the coexistence of a mature cystic teratoma and a cystadenoma. The O-RADS system was able to sensitively detect malignant tumors in this series. A typical dermoid cyst with an anechoic cavity or a multilocular cyst with a dermoid sac may signify a benign collision tumor.

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“…Para reducir el riesgo de diagnóstico erróneo es importante el trabajo interdisciplinario -entre médicos oncólogos, médico cirujanos y médicos patólogos-del tumor de colisión uterino (9,10), ya que puede tener implicaciones en el tratamiento y en el pronóstico. Presentamos un caso de tumor de colisión de útero conformado por un adenocarcinoma endometrial de tipo seroso papilar, de alto grado, y un adenosarcoma de cérvix con elementos heterólogos rabdomioblásticos, con el objetivo de realizar una revisión de la literatura respecto al diagnóstico histopatológico, tratamiento y pronóstico de esta condición.…”

Section: Introductionunclassified

Tumor de colisión de útero. Reporte de caso y revisión de la literatura

Ruiz-Echeverría,

Beltrán-Salazar,

Caicedo-Páez

et al. 2023

Rev. colomb. obstet. ginecol.

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Objetivos: reportar el caso de una paciente con tumor de colisión del útero y realizar una revisión de la literatura respecto al diagnóstico histopatológico, tratamiento y pronóstico de esta condición. Materiales y métodos: mujer de 76 años que consultó al centro nacional de referencia del cáncer en Bogotá (Colombia), donde se hizo el diagnóstico de tumor de colisión del útero, compuesto por un adenocarcinoma de endometrio tipo seroso y adenosarcoma de cérvix. Recibió tratamiento quirúrgico más quimioterapia y radioterapia complementaria, falleció a los 16 meses. Se realizó una búsqueda de la literatura en las bases de datos Medline vía PubMed y Embase, que incluía reportes y series de caso de mujeres con diagnóstico de tumor de colisión del útero, y se extrajo información sobre el diagnóstico, tratamiento y pronóstico. Se realizó un resumen narrativo de los hallazgos. Resultados: la búsqueda identificó 36 títulos, de los cuales se incluyeron 14 estudios que incluían 17 pacientes. El diagnóstico histopatológico más frecuente fue el adenocarcinoma endometrioide de endometrio y sarcoma endometrial de alto y bajo grado (47 %). El tratamiento básico fue quirúrgico. Cerca del 50 % recibió tratamiento adyuvante con quimioterapia y radioterapia (15 %). La sobrevida a 1 año fue del 75 %. Conclusiones: en la literatura no se identificaron casos de tumores de colisión de útero con la histopatología y en la ubicación del caso presentado. La mortalidad a dos años es cercana al 28 % si se toma en cuenta el caso reportado. Se necesitan más estudios que describan la inmunohistoquímica, el tratamiento y el pronóstico de esta condición.

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Collision Tumor of the Ovary

Abstract: We report the first case of a combined adult granulosa cell tumor and endometrioid carcinoma collision tumor occurring in an ovary.

Cited by 15 publications

References 11 publications

Composite FOXL2 Mutation-positive Adult Granulosa Cell Tumor and Serous Borderline Tumor of the Ovary

Composite FOXL2 Mutation-positive Adult Granulosa Cell Tumor and Serous Borderline Tumor of the Ovary

Ultrasound Findings andO‐RADSMalignancy Risk Stratification of Ovarian Collision Tumors

Tumor de colisión de útero. Reporte de caso y revisión de la literatura

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