Collision tumor of small cell carcinoma and squamous cell carcinoma of the maxillary sinus: Case report

Sugianto, Irfan; Yanagi, Yoshinobu; Hisatomi, Miki; Okada, Shunsuke; Takeshita, Yohei; Bamgbose, Babatunde O.; Asaumi, Junichi

doi:10.3892/mco.2022.2529

Cited by 3 publications

(3 citation statements)

References 14 publications

(20 reference statements)

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“…10 Sinonasal collision malignancies are also extraordinary peculiar, with no more than 6 previously reportorial primary cases. [11][12][13][14][15][16] Furthermore, there are no reports of simultaneous multiple malignant tumors secondary to radiotherapy in the same anatomic site in the nasal cavity in the English literature.…”

Section: Introductionmentioning

confidence: 99%

“…26 Current treatment options for these particular type of tumors have been developed primarily for the more aggressive components of neuroendocrine carcinoma. [11][12][13][14][15][16] For the SmNEC of the head and neck, Iqbal et al believed that it was best to avoid radical surgery and choose concurrent or sequential chemoradiotherapy instead, and they believed that the combined chemotherapy regimen of platinum and etoposide can provide best curative effect. 26 Furthermore, a veteran multidisciplinary group is required to develop an optimal treatment plan.…”

mentioning

confidence: 99%

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Secondary Sinonasal Collision Tumor of Papillary Squamous Cell Carcinoma and Small Cell Neuroendocrine Carcinoma After Nasopharyngeal Carcinoma Radiotherapy: A Case Report and Literature Review of Sinonasal Collision Carcinomas

Tang¹,

Wang²,

Xu³

et al. 2023

OTT

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In the head and neck region, small cell neuroendocrine carcinoma (SmNEC) is extraordinary infrequent. Collision malignancy is also a rare entity in the nasal cavity, with merely sporadic 6 case reports on primary collision tumor associated with neuroendocrine carcinoma. The development of a secondary SmNEC within the previous radiation field had uncommonly been described, and there was no report on secondary sinonasal collision carcinoma with SmNEC component as a side reaction of nasopharyngeal carcinoma (NPC) radiotherapy. In light of the rarity of these neoplasms, we presented a case of a sinonasal collision carcinoma of papillary squamous cell carcinoma (PSCC) and SmNEC after NPC radiotherapy. To our knowledge, it may be the first case of a secondary coexistence of two malignancies synchronously in the nasal cavity after NPC treatment. Recognizing this peculiar kind of collision tumor associated SmNEC could promote our understanding of this entity and hence propose optimal treatment strategies.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Secondary Sinonasal Collision Tumor of Papillary Squamous Cell Carcinoma and Small Cell Neuroendocrine Carcinoma After Nasopharyngeal Carcinoma Radiotherapy: A Case Report and Literature Review of Sinonasal Collision Carcinomas

Tang¹,

Wang²,

Xu³

et al. 2023

OTT

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“…Despite being small anatomical regions, the sinonasal cavities harbor a great number of histologically different cancers, including epithelial types such as squamous cell carcinoma (SNSCC), salivary gland tumors and intestinal-type adenocarcinoma (ITAC); neuroendocrine types such as olfactory neuroblastoma (ONB), neuroendocrine carcinoma (SNEC) and malignant mucosal melanoma (MMM); and various forms of sarcoma [ 1 , 2 ]. Sinonasal tumors also frequently display more than one histological appearance, e.g., ITAC with ONB, SNEC with ONB, and SNEC with SNSCC or ITAC [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Such mixed or collision tumors occur at the time of presentation, but cases where locoregional recurrences arise histologically different from their corresponding primary tumors have also been described, for example, ITAC recurring as undifferentiated carcinoma (SNUC) or ONB recurring as non-ITAC adenocarcinoma [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of a Preclinical In Vitro Model Derived from a SMARCA4-Mutated Sinonasal Teratocarcinosarcoma

Lorenzo-Guerra,

Codina-Martínez,

Suárez-Fernández

et al. 2023

Cells

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Sinonasal teratocarcinosarcoma (TCS) is a rare tumor that displays a variable histology with admixtures of epithelial, mesenchymal, neuroendocrine and germ cell elements. Facing a very poor prognosis, patients with TCS are in need of new options for treatment. Recently identified recurrent mutations in SMARCA4 may serve as target for modern therapies with EZH1/2 and CDK4/6 inhibitors. Here, we present the first in vitro cell line TCS627, established from a previously untreated primary TCS originating in the ethmoid sinus with invasion into the brain. The cultured cells expressed immunohistochemical markers, indicating differentiation of epithelial, neuroepithelial, sarcomatous and teratomatous components. Whole-exome sequencing revealed 99 somatic mutations including SMARCA4, ARID2, TET2, CDKN2A, WNT7A, NOTCH3 and STAG2, all present both in the primary tumor and in the cell line. Focusing on mutated SMARCA4 as the therapeutic target, growth inhibition assays showed a strong response to the CDK4/6 inhibitor palbociclib, but much less to the EZH1/2 inhibitor valemetostat. In conclusion, cell line TCS627 carries both histologic and genetic features characteristic of TCS and is a valuable model for both basic research and preclinical testing of new therapeutic options for treatment of TCS patients.

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Experimental Models of Sinonasal Tumors for Preclinical Testing of Candidate Targeted Therapies

Codina-Martínez,

Lorenzo-Guerra,

Cabal

et al. 2023

Curr Otorhinolaryngol Rep

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Collision tumor of small cell carcinoma and squamous cell carcinoma of the maxillary sinus: Case report

Cited by 3 publications

References 14 publications

Secondary Sinonasal Collision Tumor of Papillary Squamous Cell Carcinoma and Small Cell Neuroendocrine Carcinoma After Nasopharyngeal Carcinoma Radiotherapy: A Case Report and Literature Review of Sinonasal Collision Carcinomas

Secondary Sinonasal Collision Tumor of Papillary Squamous Cell Carcinoma and Small Cell Neuroendocrine Carcinoma After Nasopharyngeal Carcinoma Radiotherapy: A Case Report and Literature Review of Sinonasal Collision Carcinomas

Characterization of a Preclinical In Vitro Model Derived from a SMARCA4-Mutated Sinonasal Teratocarcinosarcoma

Experimental Models of Sinonasal Tumors for Preclinical Testing of Candidate Targeted Therapies

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