Collision tumor consisting of a colorectal adenocarcinoma and dissemination of a gastric adenocarcinoma

Miyamoto, Ryoichi; Kikuchi, Kazunori; Uchida, Atsushi; Ozawa, Masayoshi; Kemmochi, Akira; Sano, Nobuyuki; Tadano, Sosuke; Inagawa, Satoshi; Adachi, Shinya; Yamamoto, Masayoshi

doi:10.1177/2050313x17751839

Cited by 9 publications

(5 citation statements)

References 17 publications

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“…Collision and hybrid tumours represent the occurrence of two or more distinct synchronous primary tumours, benign or malignant, appearing in the same anatomic region. Hybrid tumours are composed of two or more different tumour types in a single neoplasm within the same topographic location, whereas collision tumours are lesions that originate at different locations in the same region or organ and coalesce in a particular area …”

Section: Association With Other Salivary Gland Tumours and Other Extrmentioning

confidence: 99%

Cytopathology and diagnostics of Warthin's tumour

Sučić

Ljubić²,

Perković³

et al. 2020

Cytopathology

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Warthin's tumour (WT) is a benign epithelial salivary tumour, one type of salivary adenoma. Histologically, WT is structured of two components, epithelial tissue that often lines cystic formations and lymphoid tissue in the tumour stroma. FNA is a reliable diagnostic approach in the diagnosis of salivary gland lesions allowing a highly accurate categorization of benign tumour‐like lesions, benign tumours and malignant tumours. In the proposed Milan reporting system of salivary gland lesions, WT is categorized in the IVA group of benign neoplasms. Accurate cytological diagnosis is straightforward when three characteristic components are present: oncocytes, either isolated or associated in clusters, lymphocytes and lymphoid cells and often an inflammatory/necrotic‐like substance. Also, specific features of scintigraphy and radiological imaging contribute to the diagnosis of WT. WT is categorized according to Seifert G. et al in 4 types, depending on the proportions of the epithelial component and lymphoid stroma. Differential cytopathological and pathohistological diagnosis include other salivary gland lesions with lymphoid, oncocytic epithelial and cystic components. In some cases, such as the metaplastic WT variant, there are additional cytopathological and histological diagnostic difficulties. Moreover, bilateral, multicentric or multiple and infrequently seen extra‐salivary localizations of WT are associated with further cytopathological diagnostic difficulties. Also, a rare possibility of malignant transformation of the epithelial or lymphoid component of WT as well as possible association with other primary tumours remains a challenge in accurate cytopathological and histological diagnosis of WT.

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Section: Association With Other Salivary Gland Tumours and Other Extrmentioning

confidence: 99%

Cytopathology and diagnostics of Warthin's tumour

Sučić

Ljubić²,

Perković³

et al. 2020

Cytopathology

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“…The pathogenesis of these tumors is unclear and debated, multiple hypotheses have been suggested as to the origin of collision tumors: (1) Some researchers[ 11 ] suggest that the components of the mixed tumor arise from different precursor cells independently, as metachronous or synchronous carcinoma. During their development, they may contact each other by accident; (2) A number of other researchers[ 12 ] regard a type of pluripotent stem cell as the progenitor of collision tumor, which has bidirectional differentiation under the action of carcinogenesis; (3) Another hypothesis is similar to the above assumption, that neuroendocrine neoplasms develop from an epithelial phenotype, which is supported by molecular and genetic aberrations; and (4) The last hypothesis suggests that they occur contiguously.…”

Section: Discussionmentioning

confidence: 99%

Collision carcinoma of the rectum involving neuroendocrine carcinoma and adenocarcinoma: A case report

Zhao

Zhang

2021

WJCC

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BACKGROUND Collision carcinoma is a rare histological pattern, and includes two or more different types of tumors coexisting in the same organ as one neoplasm. Different to the combined type, the two adjacent tumors of collision carcinoma are histologically distinct. Collision carcinoma may occur from any origin or organ, including the cecum, liver, cervix, thyroid, stomach, kidney, and esophagus. In the rectum, adenocarcinoma is the most common pathological type, the combined type is rare, and collision tumors are even rarer. To date, only a limited number of collision carcinoma cases originating from the rectum have been reported. Due to the scarcity of rectal collision carcinoma, more cases need to be reported to fully understand the clinico-pathological features and biological behavior of the tumor. CASE SUMMARY Here we report a 40-year-old female who presented with the chief complaints of persistent changes in bowel habits and hematochezia for 10 d. She underwent Miles' operation which revealed a collision carcinoma of the rectum, showing a “side by side” pattern, composed of a high grade neuroendocrine carcinoma, (small cell carcinoma) and moderately differentiated adenocarcinoma, based on its clinico-pathological features and biological behavior. The patient remained disease-free at 12 mo follow-up. We also focused on the related literature and expert opinion. CONCLUSION Collision carcinoma is a rare tumor with ambiguous biological behavior. Greater attention should be paid to its clinico-pathologic diagnosis. Regular and adequate follow-up is essential to help rule out metastasis and assess the prognosis.

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“…To date, within the gastro-intestinal tract, in the English literature, gastric adenocarcinomas have been described that collide with lymphomas, gastrointestinal stromal tumors, squamous cell carcinomas, and neuroendocrine tumors [5], as well as colorectal carcinomas coexisting with neuroendocrine tumors, leiomyosarcomas, lymphomas, Schwann cell hamartoma, gastrointestinal stromal tumors, or metastatic gastric adenocarcinoma [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Collision Tumors of the Colon and Peritoneum: Signet-Ring Cell Carcinoma and Granular Cell Tumor

Lazureanu,

Anderco,

Dema

et al. 2023

Life

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Collision tumors, although rare, characterized by two distinctive (morphological, as well immunohistochemical) and spatially independent tumor components at the same location, are always puzzling for clinicians, pathologists, and patients because they do not fit into the usual approaches, being neither diagnostic nor therapeutic. Reviewing the specialized literature, to date, collision tumors have been reported in multiple locations such as the skin, esophagus, stomach, intestine, liver, kidney, bladder, adrenal gland, or thyroid. We report a case of coexistence at the same site of a malignant tumor of the ascending colon and a benign tumor emerging from the peritoneal lining, initially thought by the surgeon to be right-sided serosal carcinomatosis. But histopathological examination reveals that those multiple serosal nodules were benign granular cell tumors that have collided with highly aggressive transparietal signet-ring colon carcinoma. These results put the patient’s prognosis and therapeutic strategy in a different light than the clinical and intraoperative evaluation.

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Collision tumor consisting of a colorectal adenocarcinoma and dissemination of a gastric adenocarcinoma

Cited by 9 publications

References 17 publications

Cytopathology and diagnostics of Warthin's tumour

Cytopathology and diagnostics of Warthin's tumour

Collision carcinoma of the rectum involving neuroendocrine carcinoma and adenocarcinoma: A case report

Collision Tumors of the Colon and Peritoneum: Signet-Ring Cell Carcinoma and Granular Cell Tumor

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