Collision tumor comprising metastatic cholangiocarcinoma and seminoma in an undescended testis: a case report

Abstract

Testicular metastasis of solid tumors is uncommon. Common primary sites of metastatic tumors to the testis are the lungs and prostate. Cryptorchidism is associated with a four-fold increase in the risk of a testicular germ cell tumor of which seminoma is the most common type. We report an extremely rare case of a collision tumor that comprised testicular metastasis of intrahepatic cholangiocarcinoma and a seminoma in an undescended testis. To the best of our knowledge, this is the first case of this type of tumor to be described. Awareness that metastatic intrahepatic cholangiocarcinoma may present as a testicular tumor may aid diagnosis and management of such patients.

Molecular Characterization of Patients with Cryptorchidism: Preliminary Search for an Expression Profile Related to That of Testicular Germ-Cell Tumors

“…In contrast, a recent study identified under-expression of the hsa-miR-371-373 cluster in three patients with CO [ 30 ], a result in contrast with ours, possibly due to the low number of patients included in the cited study. Therefore, our results highlight the need to determine the expression of these miRNAs in a larger cohort of patients, with the intention of identifying those CO patients who are at high risk of developing TGCT, as has been proposed in other studies [ 31 , 32 ].…”