Collision of communicable and non-communicable disease epidemics—the case of HIV and COPD

Stolbrink, Marie; Mortimer, Kevin

doi:10.1016/s2214-109x(17)30489-8

Cited by 4 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The highest prevalence occurs in the Americas [16,17], where its prevalence has increased over the past 20 years. Despite the growing global burden, COPD is neglected in low-income countries, where it is considered a non-communicable disease [18,19]. In Canada, the risk of developing COPD is similar to that of developing diabetes, which is more significant than the risk of developing congestive heart failure [20].…”

Section: Epidemiologymentioning

confidence: 99%

Mechanisms, Pathophysiology and Currently Proposed Treatments of Chronic Obstructive Pulmonary Disease

et al. 2021

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is one of the leading global causes of morbidity and mortality. A hallmark of COPD is progressive airflow obstruction primarily caused by cigarette smoke (CS). CS exposure causes an imbalance favoring pro- over antioxidants (oxidative stress), leading to transcription factor activation and increased expression of inflammatory mediators and proteases. Different cell types, including macrophages, epithelial cells, neutrophils, and T lymphocytes, contribute to COPD pathophysiology. Alteration in cell functions results in the generation of an oxidative and inflammatory microenvironment, which contributes to disease progression. Current treatments include inhaled corticosteroids and bronchodilator therapy. However, these therapies do not effectively halt disease progression. Due to the complexity of its pathophysiology, and the risk of exacerbating symptoms with existing therapies, other specific and effective treatment options are required. Therapies directly or indirectly targeting the oxidative imbalance may be promising alternatives. This review briefly discusses COPD pathophysiology, and provides an update on the development and clinical testing of novel COPD treatments.

show abstract

Section: Epidemiologymentioning

confidence: 99%

Mechanisms, Pathophysiology and Currently Proposed Treatments of Chronic Obstructive Pulmonary Disease

et al. 2021

View full text Add to dashboard Cite

show abstract

“…An increase in the prevalence of NCDs in Africa has resulted in the competition of disease priorities on strained healthcare systems already burdened by communicable diseases. [1][2][3] Morbidity and mortality due to NCDs are mostly attributed to the four major diseases, namely, cardiovascular diseases (CVDs), cancers, respiratory diseases, and diabetes. The World Health Organization 2018 Report on NCDs cited that the diseases caused 15 million premature deaths of people aged between 30 and 39 years with over 85% of these deaths occurring in LMICs.…”

Section: Introductionmentioning

confidence: 99%

The Nexus Between Adherence to Recommended Lifestyle Behaviors and Blood Pressure Control in Hypertensive Patients at Mutare Provincial Hospital, Zimbabwe: A Cross-Sectional Study

Tozivepi¹,

Takawira²,

Chikaka³

et al. 2021

PPA

View full text Add to dashboard Cite

Patients and Methods: A cross-sectional study was conducted using BP readings from three consecutive months. A structured interviewer-administered and pretested questionnaire with components derived from the World Health Organization Stepwise Survey was employed to extract information from 350 purposively selected participants. Measurement of BP was based on the Eighth Joint National Committee Guidelines. Bivariate and multivariate logistic regression analyses were computed using the SPSS package. Results: The mean age of the 350 participants was 67±11.38 years. Males made up 35% of the participants and BP control was achieved in 41.4% of the patients. Only 5.1% of the participants reported adherence to all the recommended lifestyle behaviors. Low adherence rates were reported for diet, medication, and physical activity. Bivariate analysis showed that participants who adhered to antihypertensive treatment and alcohol recommendations had reduced odds of having uncontrolled hypertension, while consuming deep-fat fried foods ≥3 times a week was associated with higher odds of uncontrolled BP (p<0.1). Logistic regression analysis revealed that participants who ate traditional whole-grain "sadza" or porridge were more likely to have controlled BP [adjusted odds ratio (AOR): 1.6; 95% confidence interval (CI): 1.0-2.5] while those who did not add salt at the table had reduced odds of having uncontrolled BP by 40% (AOR: 0.6; 95% CI: 0.4-0.9). Conclusion: Overall, adherence to the recommended lifestyle behaviors which are known to be effective in controlling BP in Mutare was poor. Health workers should include comprehensive health education messages on the importance of compliance with dietary, medication, and physical exercise recommendations when counseling patients. The intervention crafting process should focus on identifying enablers of the recommended lifestyle behaviors in the community and the health delivery system.

show abstract

“…COPD is a progressive lung disease, and one of the leading causes of morbidity and mortality globally [ 370 , 371 ]. The burden of COPD on public health is such that in 1997, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) was formed, aiming to bring attention and management to the disease [ 372 ].…”

Section: Mechanistic Basis Of Pulmonary Aspergillosis In Emerging At-...mentioning

confidence: 99%

Pathogenicity and virulence of Aspergillus fumigatus

et al. 2023

View full text Add to dashboard Cite

Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major cause of morbidity and mortality globally. Compromised lung defences arising from immunosuppression, chronic respiratory conditions or more recently, concomitant viral or bacterial pulmonary infections are recognised risks factors for the development of pulmonary aspergillosis. In this review, we will summarise our current knowledge of the mechanistic basis of pulmonary aspergillosis with a focus on emerging at-risk populations.

show abstract

Collision of communicable and non-communicable disease epidemics—the case of HIV and COPD

Cited by 4 publications

References 7 publications

Mechanisms, Pathophysiology and Currently Proposed Treatments of Chronic Obstructive Pulmonary Disease

Mechanisms, Pathophysiology and Currently Proposed Treatments of Chronic Obstructive Pulmonary Disease

The Nexus Between Adherence to Recommended Lifestyle Behaviors and Blood Pressure Control in Hypertensive Patients at Mutare Provincial Hospital, Zimbabwe: A Cross-Sectional Study

Pathogenicity and virulence of Aspergillus fumigatus

Contact Info

Product

Resources

About