Collision lymph node metastasis of rectal and prostate adenocarcinomas

Collision metastasis: Renal cell carcinoma and prostatic adenocarcinoma to a retroperitoneal lymph node

“…For RCC para-aortic and paracaval lymph nodes are common locations for metastasis. 3 The collision metastasis in question aligned with the metastatic pattern of RCC.…”

“…(4) Concurrent growth of separate cell lines within the same organ. 3 , 4 The patient's history of prostatic adenocarcinoma begs the question of an alteration of a microenvironment from the recurrence of prostate cancer; however, the retroperitoneal lymph node in question is not a common location for prostate cancer to metastasize. The chance meeting of two primary tumors is also a possibility, as was hypothesized by Vyas et al due to the high vascularity of RCCs and the minute volume received by the kidneys.…”

“…As previously stated, RCC commonly presents with a second primary cancer; the incidence reaching 26.8%. 2 , 3 After a radical prostatectomy, biochemical reoccurrence is defined as a PSA of >0.2ng/mL, with 20–40% of patients experiencing such 10 years post-surgery. Of those with biochemical reoccurrence, 24–34% experience clinical manifestations, such as metastasis.…”

“…Prostatic adenocarcinoma and RCC have been demonstrated to coexist, as well as with other primary cancers such as bladder, rectal, non-Hodgkin's lymphoma, and breast cancer. 2 , 3 As such, two simultaneous primary malignancies is a relatively common phenomenon. However, the incidence of collision metastasis of both prostatic adenocarcinoma and RCC is a rare phenomenon.…”

Collision tumour of two nodal metastases (adenocarcinoma and mast cell tumour) in a dog

“…Microscopically, a mixed or composite tumour will have admixing of the cell types, whereas in a collision tumour, both cell types are present but separate. 4 Collision tumours are rare but have been reported in humans, [5][6][7][8][9] dogs, 1 4 10 11 a rabbit, 12 a hamster 13 and a goat. 14 In the human literature, collision tumours in both primary sites 5 9 15 and metastatic lymph nodes 6 8 16 have been reported.…”