Collision Glial Neoplasms Arising in an Ovarian Mature Cystic Teratoma: A Rare Event

Abstract

Germ cell neoplasms represent around 20% of all ovarian tumors. They most frequently affect children and young adults. Mature cystic teratoma is a common benign ovarian neoplasm comprising about 95% and is made up of all three germ cell embryonic layers. By definition, mature cystic teratoma may be derived from any of the three germ cell lines. On the other hand, immature teratomas contain primitive neuroepithelial elements. However, it is quite uncommon in the English literature to have a neuroepithelial glial neoplasm arising in a mature cystic teratoma of an adolescent. Interestingly enough, all published cases described a single type of glial neoplasm arising in mature ovarian teratoma. Herein, the authors discuss a unique case of concomitant occurrence of two different glial neoplasms, namely pilocytic astrocytoma and subependymoma arising in an ovarian mature cystic teratoma. To the best of our knowledge, this is the first reported case with such a distinctive histopathologic finding.

Ultrasound Findings andO‐RADSMalignancy Risk Stratification of Ovarian Collision Tumors

“…To our knowledge, there have been 25 reports on 45 ovarian collision tumors in English language literature, 1–6,9–25 since YM Bhende reported a Brenner tumor in the wall of a serous cystadenoma in 1947 9 . The histological findings were described for all 45 ovarian collision tumors, with 14 combinations of teratomas and cystadenomas, 9 teratomas and cystadenocarcinomas, 12 cystadenomas/cystadenocarcinomas and other tumors, 6 teratomas and other tumors, and 4 other extremely rare combinations 4,10–12 . Diagnostic imaging was shown for 25 tumors, including 17 MRI, 3 CT, and 5 ultrasonography scans 2,5,6,13 .…”

“…To our knowledge, previous reports were single case reports or case series. Most studies have focused on histological identification and diagnosis 3,4 . With the progress of pathological technology, reports of ovarian collision tumors are increasing.…”

“…Most studies have focused on histological identification and diagnosis. 3,4 With the progress of pathological technology, reports of ovarian collision tumors are increasing. The most commonly reported component of ovarian collision tumors is teratomas or sex cordstromal tumors.…”

Mature ovarian teratoma with gliomatosis peritonei: A rare case report

“…2 GP is composed of miliary-like grayish nodules of mature glial and neuronal tissue without any other teratomatous component on the peritoneal surface and omentum and, thus, is considered a benign process. 6 Though the origin of GP remains uncertain, two theories to explain its etiology have been proposed. In one, implantation of glial tissue in the peritoneum occurs either through rupture of the capsule with subsequent implantation of teratomatous tissue or via lymphatic spread as in metastasis of carcinomas, while in other, pluripotent stem cells in the peritoneum or subjacent mesenchyme undergo glial metaplasia.…”

Dentigerous Equine Teratoma in a Stallion: Surgical Management and Clinicopathology

“…Teratoma is a rare embryonic tumor that can be both benign or malignant, most often diagnosed as benign. Teratoma is composed of mature somatic tissue that is not well organized and composed of neoplastic germ cells [ 1 ] originating from all three layers of embryonic germ cells: ectoderm, mesoderm and endoderm (ex: epithelium, brain, bone, cartilage) [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. In human medicine these tumors that originate from all three germ layers are also called “tridermomas”; this term is not currently used in veterinary medicine.…”