Collision and reaction cells in atomic mass spectrometry: development, status, and applicationsThe opinions expressed in the following article are entirely those of the authors and do not necessarily represent the views of the Royal Society of Chemistry, the Editor or the Editorial Board of JAAS.

Characterisation of gas cell reactions for 70+ elements using N2O for ICP tandem mass spectrometry measurements

“…16 This, in turn, can lead to increased sensitivity of the target analyte. Gases that have previously demonstrated a collisional focusing effect include hydrogen, 12,17 helium, 1,18,19 and NH 3 . 20,21 While the choice of reaction gas is an important consideration for removal of interferences, differences in the types of reaction cells used have shown to have a signicant contribution to the removal of interferences.…”

ICP-MS-Based Methodology In Metallomics: Towards Single Particle Analysis, Single Cell Analysis, And Spatial Metallomics

“…14 Different mass analyzers are utilized in ICP-MS, such as the quadrupole, magnetic sector analyzer, and ion trap. 15 Besides solution analysis, in situ solid sampling can be achieved when laser ablation (LA) is used as the sample introduction system. In LA-ICP-MS analysis, solid samples are ablated with highpower laser shots, and the resulting aerosol is transported and analyzed by ICP-MS. 16 LA-ICP-MS has the unique advantages of high spatial resolution (down to ~1 μm), minimal sample preparation, and high sensitivity (<1 fg for many elements).…”

An evaluation of M2+ interference correction approaches associated with As and Se in ICP-MS using a multi-day dataset along with ICP-MS/MS/HR-ICP-MS based analysis and hierarchical modeling as a means of assessing bias in fortified drinking waters and single component matrices

“…The inclusion of interference reduction technologies has only enhanced the adoption of ICP-MS based methodologies by increasing specificity, 7 but this enhanced specificity has not been realized for M 2+ based interferences. 8–14 Reaction cell approaches can provide enhanced interference reduction and analyte signal preservation 15–20 when compared to helium (He)-collision cell, but this enhanced performance is generally limited to a few elements in a well-defined matrix. In the context of M 2+ interferences, the use of hydrogen (H 2 ) has been shown to reduce Gd 2+ .…”