Collision-activated dissociation of negative ions in an ion trap mass spectrometer

McLuckey, Scott A.; Glish, Gary L.; Kelley, Paul E.

doi:10.1021/ac00140a019

Cited by 68 publications

(29 citation statements)

References 20 publications

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“…-]. The above peaks are consistent between the two sources as well as those observed with NCI literature spectra using filament thermionic emitters [35,37,39]. Finally, the small peak at m/z 176 could be attributed to [(RDX -…”

Section: Tntsupporting

confidence: 87%

“…The same emission currents used for PFTBA spectra collection were also used with the trace explosives (50 μA for the CNT field emission source and 200 μA for the filament thermionic source). The normalized mass spectra for TNT collected using the CNT field emission source and filament thermionic emission source are shown in Figure 4a and d, respectively, and correlate well with each other as well as literature spectra collected with filament thermionic emitters [35,37]. Gas molecules in relatively high pressure ion sources can collisionally cool electrons to kinetic energies near 0 eV.…”

Section: Evidence For Chemical Ionizationsupporting

confidence: 64%

“…The presence of the molecular anion is strong evidence of chemical ionization. Electron transfer from the reagent ions and electron capture can both result in molecular ions [37].…”

Section: Tntmentioning

confidence: 99%

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Chemical Ionization Mass Spectrometry Using Carbon Nanotube Field Emission Electron Sources

Radauscher

Keil

Wells

et al. 2015

J. Am. Soc. Mass Spectrom.

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Abstract. A novel chemical ionization (CI) source has been developed based on a carbon nanotube (CNT) field emission electron source. The CNT-based electron source was evaluated and compared with a standard filament thermionic electron source in a commercial explosives trace detection desktop mass spectrometer. This work demonstrates the first reported use of a CNT-based ion source capable of collecting CI mass spectra. Both positive and negative modes were investigated. Spectra were collected for a standard mass spectrometer calibration compound, perfluorotributylamine (PFTBA), as well as trace explosives including trinitrotoluene (TNT), Research Department explosive (RDX), and pentaerythritol tetranitrate (PETN). The electrical characteristics, lifetime at operating pressure, and power requirements of the CNT-based electron source are reported. The CNT field emission electron sources demonstrated an average lifetime of 320 h when operated in constant emission mode under elevated CI pressures. The ability of the CNT field emission source to cycle on and off can provide enhanced lifetime and reduced power consumption without sacrificing performance and detection capabilities.

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Section: Tntsupporting

confidence: 87%

Section: Evidence For Chemical Ionizationsupporting

confidence: 64%

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Chemical Ionization Mass Spectrometry Using Carbon Nanotube Field Emission Electron Sources

Radauscher

Keil

Wells

et al. 2015

J. Am. Soc. Mass Spectrom.

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“…IMC techniques such as (i) DC pulse excitation (Lammert & Cooks, 1992) to effect ejection (Weil et al, 2000) or to force ions into coherent motion with characteristic secular frequencies and (ii) resonant AC dipolar excitation (March et al, 1991) for the purposes of broad-band excitation (Julian & Cooks, 1993), resonant ejection (Fulford et al, 1980), ion isolation (McLuckey, Goeringer, & Glish, 1991) or collisioninduced dissociation (McLuckey, Glish, & Kelley, 1987), have been successfully implemented in the QIT. These methods provide ways to interrogate the structure of ions by collision-and surface-induced dissociation (SID) (Lammert & Cooks, 1992), as well as to characterize ion trajectories in the QIT during ion tomography experiments (Weil et al, 2000).…”

Section: Manipulation Of Ions Confined In the Orbitrapmentioning

confidence: 99%

Orbitrap mass spectrometry: Instrumentation, ion motion and applications

Perry

Cooks

Noll

2008

Mass Spectrometry Reviews

401

290

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Since its introduction, the orbitrap has proven to be a robust mass analyzer that can routinely deliver high resolving power and mass accuracy. Unlike conventional ion traps such as the Paul and Penning traps, the orbitrap uses only electrostatic fields to confine and to analyze injected ion populations. In addition, its relatively low cost, simple design and high space‐charge capacity make it suitable for tackling complex scientific problems in which high performance is required. This review begins with a brief account of the set of inventions that led to the orbitrap, followed by a qualitative description of ion capture, ion motion in the trap and modes of detection. Various orbitrap instruments, including the commercially available linear ion trap–orbitrap hybrid mass spectrometers, are also discussed with emphasis on the different methods used to inject ions into the trap. Figures of merit such as resolving power, mass accuracy, dynamic range and sensitivity of each type of instrument are compared. In addition, experimental techniques that allow mass‐selective manipulation of the motion of confined ions and their potential application in tandem mass spectrometry in the orbitrap are described. Finally, some specific applications are reviewed to illustrate the performance and versatility of the orbitrap mass spectrometers. © 2008 Wiley Periodicals, Inc., Mass Spec Rev 27: 661–699, 2008

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“…[2][3][4][5][6] There are few reports on negative-ion chemical ionization involving both reagent and sample-ion generation inside a quadrupole ion trap. [7][8][9] This is due partly to the very low efficiency of negative-ion formation in the trap and to the problem of positive-ion/negative-ion recombination. 8 Positive-ion/negative-ion recombination may be reduced during negative reagent ion formation by the application of a negative DC voltage to the ring electrode to eject all positive ions whilst retaining the negative reagent ions within the ion trap.…”

mentioning

confidence: 99%

Negative-ion chemical ionization reactions of the hydroxy anion, [OH]−, and the benzoyl anion, [C6H5CO]−, in a quadrupole ion trap

Williamson¹,

Creaser²

1997

Rapid Commun. Mass Spectrom.

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Collision-activated dissociation of negative ions in an ion trap mass spectrometer

Cited by 68 publications

References 20 publications

Chemical Ionization Mass Spectrometry Using Carbon Nanotube Field Emission Electron Sources

Chemical Ionization Mass Spectrometry Using Carbon Nanotube Field Emission Electron Sources

Orbitrap mass spectrometry: Instrumentation, ion motion and applications

Negative-ion chemical ionization reactions of the hydroxy anion, [OH]−, and the benzoyl anion, [C6H5CO]−, in a quadrupole ion trap

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