Collimated prompt gamma TOF measurements with multi-slit multi-detector configurations

Krimmer, J.; Chevallier, M.; Constanzo, Julie; Dauvergne, D.; Rydt, M. De; Dedes, G.; Freud, N.; Henriquet, P.; Tessa, Chiara La; Létang, Jean Michel; Pleskač, R.; Pinto, M.; Ray, C.; Reithinger, V.; Richard, M.-H.; Rinaldi, I.; Roellinghoff, F.; Schuy, Christoph; Testa, É.; Testa, M.

doi:10.1088/1748-0221/10/01/p01011

Cited by 33 publications

(28 citation statements)

References 30 publications

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“…It has been shown experimentally that the longitudinal distribution of such prompt-gamma production is highly correlated to the primary ion range [2], [3]. In the CLaRyS collaboration, two systems for prompt gamma detection are currently under development [4], [5], [6]: a collimated gamma camera and a Compton camera (Fig. 1).…”

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confidence: 99%

A large area diamond-based beam tagging hodoscope for ion therapy monitoring

et al. 2018

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Abstract-. The MoniDiam project is part of the French national collaboration CLaRyS (Contrôle en Ligne del'hAdronthérapie par RaYonnements Secondaires) for on-line monitoring of hadron therapy. It relies on the imaging of nuclear reaction products that is related to the ion range. The goal here is to provide large area beam detectors with a high detection efficiency for carbon or proton beams giving time and position measurement at 100 MHz count rates (beam tagging hodoscope). High radiation hardness and intrinsic electronic properties make diamonds reliable and very fast detectors with a good signal to noise ratio. Commercial Chemical Vapor Deposited (CVD) polycrystalline, heteroepitaxial and monocrystalline diamonds were studied. Their applicability as a particle detector was investigated using α and β radioactive sources, 95 MeV/u carbon ion beams at GANIL and 8.5 keV X-ray photon bunches from ESRF. This facility offers the unique capability of providing a focused (~1 µm) beam in bunches of 100 ps duration, with an almost uniform energy deposition in the irradiated detector volume, therefore mimicking the interaction of single ions. A signal rise time resolution ranging from 20 to 90 ps rms and an energy resolution of 7 to 9% were measured using diamonds with aluminum disk shaped surface metallization. This enabled us to conclude that polycrystalline CVD diamond detectors are good candidates for our beam tagging hodoscope development. Recently, double-side stripped metallized diamonds were tested using the XBIC (X Rays Beam Induced Current) set-up of the ID21 beamline at ESRF which permits us to evaluate the capability of diamond to be used as position sensitive detector. The final detector will consist in a mosaic arrangement of double-side stripped diamond sensors read out by a dedicated fast-integrated electronics of several hundreds of channels. therapy. Ions deposit a large fraction of the dose at the end of their path, in the Bragg peak. Compared to conventional X-ray radiotherapy, hadron therapy allows a more efficient dose delivery in the tumor, with a reduction of the dose deposited in the nearby healthy organs. The conformation of the deposited dose to the tumor volume is provided by distributing Bragg peaks in this volume, either spot by spot, or by means of passive scattering and energy degradation. However, since multiple sources of uncertainty on the ion range may cause deviations from the planned dose distribution [1], online control of the ion range is desired in order to reduce safety margins and optimize the ballistic advantage of ion therapy.During an irradiation with ion beams, nuclear reactions occur for part of the projectiles along their path in the patient body, and photons in the range 1-10 MeV are emitted almost isotropically within much less than a picosecond after the reactions. It has been shown experimentally that the longitudinal distribution of such prompt-gamma production is highly correlated to the primary ion range

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confidence: 99%

A large area diamond-based beam tagging hodoscope for ion therapy monitoring

et al. 2018

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“…The energy spectrum of these photons allowed the observation of the prominent PG emission lines and the selection of two energy windows to study their yield and spatial correlation with respect to the BP, and their temporal and detection properties. The first energy selection had a threshold of ≥1 MeV, which eliminates the low-energy background photon counts [49], and the second had a 3.0-7.0 MeV window, which includes the prominent PG emission lines and has been employed in previous studies [50,51]. The primary PG rays are referred to those produced from the primary particle beam interactions, and the secondary PG rays are referred to those produced from the interactions of the secondary radiation field.…”

Section: Methodsmentioning

confidence: 99%

Characterization of prompt gamma ray emission for in vivo range verification in particle therapy: A simulation study

Zarifi¹,

Guatelli²,

Qi³

et al. 2019

Physica Medica

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In this paper we investigate the emission and detection characteristics of prompt gamma (PG) rays for in vivo range verification during hadron therapy, using Geant4 simulations. Proton, 4 He and 12 C beams of varying energy are incident on water phantoms. The PG production yield, energy spectral characteristics and spatial correlation with the Bragg Peak (BP) have been quantified. Further, the angular distributions for PG detection with respect to a point-of-reference on the phantom surface have been explored. The temporal properties of PG emission and time-of-flight (TOF) of PG detection have also been investigated in correlation with the changing particle beam range. Our results show that the primary PG rays from nuclear interactions of the primary beam exhibit the closest correlation to the beam range but its signal is significantly masked by the concurrent secondary PG rays, particularly for heavier ions such as carbon ion beams. The PG TOF spectroscopy encodes the essential information of the beam range but requires high time resolution measurements to retrieve it. A hybrid PG detection system to utilize the energy, timing and spatial characteristics of PG rays is desirable for BP tracking in real-time. AbstractIn this paper we investigate the emission and detection characteristics of prompt gamma (PG) rays for in vivo range verification during hadron therapy, using Geant4 simulations. Proton, 4 He and 12 C beams of varying energy are incident on water phantoms.The PG production yield, energy spectral characteristics and spatial correlation with the Bragg Peak (BP) have been quantified.Further, the angular distributions for PG detection with respect to a point-of-reference on the phantom surface have been explored.The temporal properties of PG emission and time-of-flight (TOF) of PG detection have also been investigated in correlation with the changing particle beam range. Our results show that the primary PG rays from nuclear interactions of the primary beam exhibit the closest correlation to the beam range but its signal is significantly masked by the concurrent secondary PG rays, particularly for heavier ions such as carbon ion beams. The PG TOF spectroscopy encodes the essential information of the beam range but requires high time resolution measurements to retrieve it. A hybrid PG detection system to utilize the energy, timing and spatial characteristics of PG rays is desirable for BP tracking in real-time.

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“…6(b), the BIC physics list did not reproduce any of the expected 16 O c rays (6.13 MeV, 6.92 MeV, and 7.11 MeV), except the 4.43 MeV peak from the a decay of 16 O into 12 C. In the c spectra obtained with QMD and INCL ++ , the following were observed, as expected: 48 2 À level at 2.7 MeV, 3 À level at 6.13 MeV, 2 + level at 6.92 MeV, and 1 À level at 7.11 MeV from the 16 O de-excitation. The 2.31 MeV c line originating from the 16 O (n,x) 14 N reaction was predicted only on BIC and INCL ++ . Finally, a peak between 5 and 5.5 MeV was observed on the INCL ++ and BIC spectra, which corresponded to the two peaks at 5.25 and 5.30 MeV from 15 N generated by the 16 O (n,x) 15 N reaction.…”

Section: D Physical Processes Producing the Prompt-cmentioning

confidence: 97%

“…Experimental approaches considered so far are based on tracking secondary protons, [2][3][4][5] detecting prompt-c emission, 6,7 or performing online PET gamma reconstruction. [8][9][10] Several modalities for prompt-c imaging have been investigated: collimated cameras, [11][12][13][14][15] compton cameras [16][17][18][19][20][21][22][23] and prompt-c timing. 24 One important parameter is the production yield of secondary particles used in these methods during treatment, as this will affect the accuracy of the reconstructed dose distribution.…”

Section: Introductionmentioning

confidence: 99%