collier, a novel regulator of Drosophila head development, is expressed in a single mitotic domain

Crozatier, Michèle; Valle, Denise; Dubois, L.; Koraichi, Saâd Ibnsouda; Víncent, Alaín

doi:10.1016/s0960-9822(09)00452-7

Cited by 130 publications

(136 citation statements)

References 49 publications

(75 reference statements)

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“…Degenerate RT-PCR was performed with two degenerate primers (5Ј-GGCCGGATCCTTYTTYYTNAARTTYTTYCT-3Ј and 5Ј-GGCCGAATTCGTNCCYTTRCARAAYTGYTT-3Ј) containing BamHI and EcoRI restriction sites, respectively. These primers corresponded to aa 186 -aa 192 (FFLKFFL, sense) and aa 333-aa 339 (KQF-CKGT, antisense), two highly conserved regions between O/E-1 and collier (Crozatier et al, 1996). PCR was conducted for 35 cycles at 50°C annealing temperature by using 1 M of each primer and 1% of reversetranscribed product from 2 g of total E14.5 RNA.…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, a Drosophila gene, collier, encoding an Olf-1/ EBF-like protein has been implicated in development. Within the developing nervous system collier is expressed in a segmentally reiterated pattern in the ventral nerve cord, in cells of the peripheral nervous system, and in patches of brain cells (Crozatier et al, 1996). These studies suggest that, besides regulating the differentiation of olfactory neurons and B-cells, Olf-1/ EBF performs a more general function in neuronal development.…”

mentioning

confidence: 87%

“…However, the absence of phenotypic changes in the olfactory epithelium of Olf-1/ EBF null mutant mice suggests that additional Olf-1 site binding proteins may exist. The high degree of conservation between mammalian Olf-1/ EBF and Drosophila collier (Crozatier et al, 1996) allowed us to design approaches for the identification of additional members in mouse. We used RT-PCR with degenerate oligonucleotides to identify Olf-1/ EBF-like genes expressed in mouse E14.5 RNA.…”

Section: Cloning Of Mammalian Olf-1/ebf-like Proteinsmentioning

confidence: 99%

“…Interestingly, the Drosophila O/ E-like gene collier does not encode an rHLH domain. Instead, an alternative HLH motif was proposed (Crozatier et al, 1996).…”

Section: The O/e Family Of Hlh Transcription Factorsmentioning

confidence: 99%

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The Characterization of the Olf-1/EBF-Like HLH Transcription Factor Family: Implications in Olfactory Gene Regulation and Neuronal Development

1997

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The Olf-1/EBF helix-loop-helix (HLH) transcription factor has been implicated in olfactory gene regulation and in B-cell development. Using homology screening methods, we identified two additional Olf-1/EBF-like cDNAs from a mouse embryonic cDNA library. The Olf-1/EBF-like (O/E) proteins O/E-1, O/E-2, and O/E-3 define a family of transcription factors that share structural similarities and biochemical activities. Although these O/E genes are expressed within olfactory epithelium in an identical pattern, they exhibit different patterns of expression in the developing nervous system. Although O/E-1 mRNA is present in several tissues in addition to olfactory neurons and developing B-cells, O/E-2 and O/E-3 are expressed at high levels only in olfactory tissue. In O/E-1 knock-out animals, the presence of two additional O/E family members in olfactory neurons may provide redundancy and allow normal olfactory neurodevelopment. Further, the identification of the O/E family of HLH transcription factors and their embryonic expression patterns suggest that the O/E proteins may have a more general function in neuronal development.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 87%

Section: Cloning Of Mammalian Olf-1/ebf-like Proteinsmentioning

confidence: 99%

“…Interestingly, the Drosophila O/ E-like gene collier does not encode an rHLH domain. Instead, an alternative HLH motif was proposed (Crozatier et al, 1996).…”

Section: The O/e Family Of Hlh Transcription Factorsmentioning

confidence: 99%

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The Characterization of the Olf-1/EBF-Like HLH Transcription Factor Family: Implications in Olfactory Gene Regulation and Neuronal Development

1997

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“…Crozatier et al (1996) identified the Olf/EBF homologue of D. melanogaster and termed this family of transcription factors the Collier/Olf/EBF (COE) family. An association between COE and OAZ (indicated by the terminology: Olf/ EBF-associated zinc finger protein) was proposed in several studies (Hata et al 2000;Reed 1997, 1998).…”

Section: Discussionmentioning

confidence: 99%

DmOAZ, the unique Drosophila melanogaster OAZ homologue is involved in posterior spiracle development

et al. 2007

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In this paper, we study DmOAZ, the unique Drosophila melanogaster homologue of the OAZ zinc finger protein family. We show partial conservation of the zinc finger organization between DmOAZ and the vertebrate members of this family. We determine the exon/intron structure of the dmOAZ gene and deduce its open reading frame. Reverse transcriptase-polymerase chain reaction analysis shows that dmOAZ is transcribed throughout life. In the embryo, strongest DmOAZ expression is observed in the posterior spiracles. We suggest that dmOAZ acts as a secondary target of the Abd-B gene in posterior spiracle development, downstream of cut and ems. In a newly created loss-of-function mutant, dmOAZ 93 , the "filzkörper" part of the posterior spiracles, is indeed structurally abnormal. The dmOAZ 93 mutant is a larval lethal, a phenotype that may be linked to the spiracular defect. Given the dmOAZ 93 mutant as a new tool, the fruit fly may provide an alternative model for analyzing in vivo the functions of OAZ family members.

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Family ofEbf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system

et al. 1997

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Two novel mouse genes, Ebf2 and Ebf3, have been identified which show high similarity to the rodent Ebf/Olf‐1 and the Drosophila collier genes. The strong conservation of the protein regions corresponding to the DNA binding and dimerisation domains previously defined in Ebf strongly suggests that Ebf2 and Ebf3 also constitute DNA sequence‐specific transcription factors. Determination of the chromosomal locations of the two genes indicated that the different members of this novel mouse multigene family are not clustered. A detailed analysis of the expression of each of the three Ebf genes in the developing central nervous system revealed partially overlapping patterns with two salient features: 1) In the region extending from the midbrain to the spinal cord, the expression of the three genes correlated with neuronal maturation, with a general activation in early post‐mitotic cells, followed by specific patterns of extinction also consistent with the neurogenic gradient. 2) In the forebrain area, although the patterns of expression of the Ebf genes also reflected neuronal maturation, they appeared in addition to be region specific. These data suggest that Ebf genes may be involved in the control of neuronal differentiation in the CNS and in enforcing regional diversity in populations of post‐mitotic forebrain neurons. Dev. Dyn. 1997;210:191–205. © 1997 Wiley‐Liss, Inc.

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collier, a novel regulator of Drosophila head development, is expressed in a single mitotic domain

Cited by 130 publications

References 49 publications

The Characterization of the Olf-1/EBF-Like HLH Transcription Factor Family: Implications in Olfactory Gene Regulation and Neuronal Development

The Characterization of the Olf-1/EBF-Like HLH Transcription Factor Family: Implications in Olfactory Gene Regulation and Neuronal Development

DmOAZ, the unique Drosophila melanogaster OAZ homologue is involved in posterior spiracle development

Family ofEbf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system

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