Colliding and interacting microbiomes and microbial communities ‐ consequences for human health

Mills, Susan; Ross, R. Paul

doi:10.1111/1462-2920.15722

Cited by 6 publications

(2 citation statements)

References 105 publications

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“…Thus, these synergistic effects may further support the potential uses of "supplementation with Lactobacillus" in antipsychotic-induced weight gain by increasing the abundance of healthy bacteria. Along with these ndings from previous and current attempts, we proposed that these signature bacteria may play a crucial role in the development of antipsychotic-induced weight gain in SZ patients, and such metabolic effects may be closely associated with the microbial function [54].…”

Section: Discussionsupporting

confidence: 60%

Gut microbiota serve as a risk predictor of weight gain in schizophrenia patients with antipsychotic medication

Liu¹,

Wu²,

Liu

et al. 2022

Preprint

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Background:Emerging evidence indicates that gut microbial dysbiosis is associated with the development of antipsychotic-induced overweight/obesity in schizophrenia (SZ). We aim to determine the taxonomic composition and metabolites profiling of “obesogenic” microbiota in SZ patients after chronic antipsychotic medication. Results:Our retrospective survey identified two groups of population separated by BMI, with 1/3 patients developing overweight/obesity after chronic antipsychotics treatment. Then, based on the 16S rRNA sequencing and multi-omics analyses, we found that SZ patients with overweight/obesity had lower relative abundances of the signature bacteria genera such as Bacteroides, Parabacteroides, Akkermansia, and Clostridium when compared to individuals with normal BMI. Further investigation revealed dysregulated energy expenditure and nutritional metabolism coupled with severe clinical indices and decreased levels of beneficial metabolites, e.g. indole-3-carboxylic acid, and propionic acid. The signature bacteria were positively associated with host metabolic homeostasis, according to the redundancy and co-occurrence analysis. Moreover, leveraging the data from first-episode drug-naïve SZ (FSZ) patients at 1-month and 1-year follow-up, both artificial neural network and random forest classifier-based prediction models demonstrated a strong ability of microbial profiles to predict antipsychotic-induced weight gain. Importantly, FSZ patients with a higher relative abundance of Parabacteria distasonisare less susceptible to antipsychotic-induced weight gain. Conclusion: Gut microbiota could serve as a noninvasive approach to predict antipsychotic-induced weight gain, guiding clinical antipsychotics administration and developing novel therapeutic strategies for the weight management in SZ.

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Section: Discussionsupporting

confidence: 60%

Gut microbiota serve as a risk predictor of weight gain in schizophrenia patients with antipsychotic medication

Liu¹,

Wu²,

Liu

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Sandifer et al ( 42 ) reported that environmental bacterial profiles are closely associated with human diseases, and exposure to microbial biodiversity help to reduce certain human diseases. Human exposure to high soil microbial diversity increases the chance of collisions between microbiomes and thus avoids the loss of specific microbiome traits ( 43 , 44 ). Although the relationship between karst ecosystems and human health requires further human disease investigations to determine, this phenomenon is noteworthy.…”

Section: Discussionmentioning

confidence: 99%

Unique Habitat of Karst Tiankengs Changes the Taxonomy and Potential Metabolism of Soil Microbial Communities

Jiang

Zeng

2023

Microbiol Spectr

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Indoor plants regulate the respiratory bacteria of high-altitude migrants and improve their environmental adaptability

Deng,

Duan,

et al. 2024

Building and Environment

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Colliding and interacting microbiomes and microbial communities ‐ consequences for human health

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 6 publications

References 105 publications

Gut microbiota serve as a risk predictor of weight gain in schizophrenia patients with antipsychotic medication

Gut microbiota serve as a risk predictor of weight gain in schizophrenia patients with antipsychotic medication

Unique Habitat of Karst Tiankengs Changes the Taxonomy and Potential Metabolism of Soil Microbial Communities

Indoor plants regulate the respiratory bacteria of high-altitude migrants and improve their environmental adaptability

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