Abstract:Norditerpenoid dilactones with various modifications on the A‐ring are common in nature, which exhibit a variety of biological and pharmaceutical activities. In this work, 31 norditerpenoid dilactone derivatives with functionalization on the A‐ and C‐rings were prepared by employed 3β‐hydroxydilactone as a common precursor. Cytotoxic evaluation showed that norditerpenoid dilactones bearing 3β‐OH and 1,2‐β‐epoxide or 2,3‐β‐epoxide displayed promising inhibitory activities against tumor cell lines (IC50=1.0–6.5 … Show more
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