Collective Learnings of Studies of Stress Granule Assembly and Composition

Sidibé, Hadjara; Velde, Christine Vande

doi:10.1007/978-1-0716-1975-9_13

Cited by 4 publications

(2 citation statements)

References 137 publications

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“…We first assessed the status of the ISR and mTOR pathways, major components of the translation-controlling program and known to be involved in SG formation in a stress-type dependent context 31 . Consistent with the literature, SA treatment induced a significant increase in the phosphorylation level of eIF2α early in the injury response; this persisted for the duration of the survival time of the cells (2 days) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Regulation of stress granule formation in human oligodendrocytes

Pernin,

Cui,

Mohammadnia

et al. 2024

Nat Commun

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Oligodendrocyte (OL) injury and subsequent loss is a pathologic hallmark of multiple sclerosis (MS). Stress granules (SGs) are membrane-less organelles containing mRNAs stalled in translation and considered as participants of the cellular response to stress. Here we show SGs in OLs in active and inactive areas of MS lesions as well as in normal-appearing white matter. In cultures of primary human adult brain derived OLs, metabolic stress conditions induce transient SG formation in these cells. Combining pro-inflammatory cytokines, which alone do not induce SG formation, with metabolic stress results in persistence of SGs. Unlike sodium arsenite, metabolic stress induced SG formation is not blocked by the integrated stress response inhibitor. Glycolytic inhibition also induces persistent SGs indicating the dependence of SG formation and disassembly on the energetic glycolytic properties of human OLs. We conclude that SG persistence in OLs in MS reflects their response to a combination of metabolic stress and pro-inflammatory conditions.

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Section: Resultsmentioning

confidence: 99%

Regulation of stress granule formation in human oligodendrocytes

Pernin,

Cui,

Mohammadnia

et al. 2024

Nat Commun

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“…Formation of stress granules: In the post-transcriptional stage, RNA-binding proteins play a key role in stress-induced regulation of the fate and function of various RNAs [128]. Protein-RNA complexes can form large granules (approximately 0.1-1.0 µm) in the cytoplasm of stressed cells, whose function is presumably to protect and store mRNA [129]. Additionally, due to their non-membrane characteristics, these structures can serve as a center where various cellular signaling pathways converge and exchange components [130].…”

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confidence: 99%

Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

Gusev

Sarapultsev

2023

IJMS

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Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from a general pathology perspective, particularly with regard to atherogenesis patterns in the context of both canonical and non-classical inflammation types. In this review, we analyze various typical phenomena and outcomes of cellular pro-inflammatory stress in atherosclerosis, as well as the role of endothelial dysfunction in local and systemic manifestations of low-grade inflammation. We also present the features of immune mechanisms in the development of productive inflammation in stable and unstable plaques, along with their similarities and differences compared to canonical inflammation. There are numerous factors that act as inducers of the inflammatory process in atherosclerosis, including vascular endothelium aging, metabolic dysfunctions, autoimmune, and in some cases, infectious damage factors. Life-critical complications of atherosclerosis, such as cardiogenic shock and severe strokes, are associated with the development of acute systemic hyperinflammation. Additionally, critical atherosclerotic ischemia of the lower extremities induces paracoagulation and the development of chronic systemic inflammation. Conversely, sepsis, other critical conditions, and severe systemic chronic diseases contribute to atherogenesis. In summary, atherosclerosis can be characterized as an independent form of inflammation, sharing similarities but also having fundamental differences from low-grade inflammation and various variants of canonical inflammation (classic vasculitis).

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Interaction between Stress Granules and Retroviruses

吴¹

2023

HJBM

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Collective Learnings of Studies of Stress Granule Assembly and Composition

Cited by 4 publications

References 137 publications

Regulation of stress granule formation in human oligodendrocytes

Regulation of stress granule formation in human oligodendrocytes

Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

Interaction between Stress Granules and Retroviruses

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