Collection of peripheral blood stem cells from normal donors 60 years of age or older

Anderlini, Paolo; Przepiorka, Donna; Lauppe, J.; Seong, D.; Giralt, Sergío; Champlin, Richard E.; Körbling, Martin

doi:10.1046/j.1365-2141.1997.302677.x

Cited by 41 publications

(27 citation statements)

References 8 publications

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“…Several small-to moderate-sized experiences have been published describing PBSC donor outcomes, focusing mainly on related donors. 4,7,10,11,[15][16][17] Short-term toxicities associated with PBSC donation reported previously generally occurred because of either (1) For personal use only. on May 7, 2018.…”

Section: Discussionmentioning

confidence: 99%

“…The practice initially involved related donors, but in more recent years this method of collection has been extended to healthy unrelated donors. Although several studies have addressed safety considerations of the procedure for small cohorts of related donors, [1][2][3][4][5][6][7][8][9][10] published unrelated donor safety experience is minimal, [11][12][13] and large, comprehensive studies of PBSC donor safety in healthy unrelated donors have not been published. In addition, previous studies have not used standardized toxicity scales, making it difficult to compare the studies with each other and giving an incomplete understanding of the donor experience.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program

Pulsipher

Chitphakdithai²,

Miller

et al. 2009

Blood

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229

223

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program

Pulsipher

Chitphakdithai²,

Miller

et al. 2009

Blood

Self Cite

229

223

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“…To our knowledge, evidence for stem/progenitor cell pool depletion in the human body with aging includes peripheral blood stem cells [8,9], satellite cells of skeletal muscle [10], and putative stem cells of the epidermal compartment of the skin [11]. Interestingly, in a retrospective analysis of >6,900 bone marrow transplantations conducted by the National Marrow Donor Program, age was the only donor trait significantly associated with recipient survival [12].…”

Section: Introductionmentioning

confidence: 99%

Age-Dependent Depletion of Human Skin-Derived Progenitor Cells

Gago¹,

Pérez-López²,

Sanz-Jaka

et al. 2009

Stem Cells

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A major unanswered question in autologous cell therapy is the appropriate timing for cell isolation. Many of the putative target diseases arise with old age and previous evidence, mainly from animal models, suggests that the stem/progenitor cell pool decreases steadily with age. Studies with human cells have been generally hampered to date by poor sample availability. In recent years, several laboratories have reported on the existence, both in rodents and humans, of skin-derived precursor (SKP) cells with the capacity to generate neural and mesodermal progenies. This easily obtainable multipotent cell population has raised expectations for their potential use in cell therapy of neurodegeneration. However, we still lack a clear understanding of the spatiotemporal abundance and phenotype of human SKPs. Here we show an analysis of human SKP abundance and in vitro differentiation potential, by using SKPs isolated from four distinct anatomic sites (abdomen, breast, foreskin, and scalp) from 102 healthy subjects aged 8 months to 85 years. Human SKP abundance and differentiation potential decrease sharply with age, being extremely difficult to isolate, expand, and differentiate when obtained from the elderly. Our data suggest preserving human SKP cell banks early in life would be desirable for use in clinical protocols in the aging population.

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“…It has been repeatedly observed that older donors tend to produce a lower CD34+ cell number requiring frequently more than one leukopheresis as compared to younger donors [8][9][10][11]. Repeated leukopheresis can pose a donor at increased risks, in particular to deeper and longer thrombocytopenia [12].…”

Section: Donor Eligibilitymentioning

confidence: 99%

Uniform examination of stem cell donors

Brand

2011

ISBT Science Series

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In contrast to unrelated donors who are counselled and examined according to international guidelines, related donors of allogeneic bone marrow (BM) or mobilized peripheral blood stem cells (PBSC) often are recruited, examined and followed otherwise. Currently, mostly PBSC instead of BM donation is used. The higher CD34+ yield is preferred for non-myeloablated recipients, allowing transplantation of older patients. Consequently related sibling donors are aging and prone to suffer more comorbidity as compared to unrelated donors. With respect to counselling it is obvious that donor recruitment and motivation between related and unrelated donors differ. The related donor however needs protection by an independent physician safeguarding the health of the donor. Although financial and logistic reasons may play a role, several differences between related and unrelated donor management are eligible for harmonization. In addition it is important to reach agreement among donor centres on uniform decisions for deferral and long-term follow-up. This requires exchange of information, not only of serious adverse reactions but also of potential hazardous situations, in order to develop more evidence-based recommendations.

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Collection of peripheral blood stem cells from normal donors 60 years of age or older

Cited by 41 publications

References 8 publications

Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program

Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program

Age-Dependent Depletion of Human Skin-Derived Progenitor Cells

Uniform examination of stem cell donors

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