Collection of MNCs and progenitor cells by two separators for PBPC transplantation: a randomized crossover trial

Abstract

Amicus is superior to Spectra in avoiding apheresis-induced thrombocytopenia caused by platelets contaminating the collected samples. Therefore, the Amicus is useful for patients with thrombocytopenia or with a less-than-normal platelet count.

Use of various offset settings in the Fenwal Amicus during hematopoietic progenitor cell collection to increase lymphocyte yield and reduce cross‐cellular contamination

“…One article has reported granulocyte content of Amicus products [5] although the values can be calculated using published data from two other articles [17,18]. These results ranged from 3.2 to 19.3 3 10 9 granulocytes, similar to the content seen in our study, especially considering that the volume of blood processed and the starting WBC counts were higher in the patients that we examined.…”

“…Most authors reported RBC content in gm of hemoglobin (Hgb) [5,18,19] rather than ml of RBC [17]. Our RBC content ranged from 16 to 32 mL, with the 1.5/6.0 offset setting at 22 mL, higher than reported results, even considering we processed twice as much blood.…”

Performance of a new separator system for routine autologous hematopoietic progenitor cell collection in small children

“…1 cells was reported superior [4] and comparable to the COBE Spectra [5,6]. The platelet contamination was lower than in other systems [4][5][6].…”

“…The platelet contamination was lower than in other systems [4][5][6]. In patients with high WBC precounts, the CE for CD34 1 cells was lower than in those with precounts < 40 G/l.…”

Apheresis instrument settings influence infused absolute lymphocyte count affecting survival following autologous peripheral hematopoietic stem cell transplantation in non-Hodgkin's lymphoma: the need to optimize instrument setting and define a lymphocyte collection target

“…They found similar collection efficiencies for CD34 þ cells, white blood cells and mononuclear cells but significantly lower collection efficiencies for platelets. 16 Significantly less whole blood was processed in our CS collection compared to the SP collections. This was because of the lower flow rates used for CS.…”