Collection of Clonorchis sinensis adult worms from infected humans after praziquantel treatment

Shen, Chenghua; Kim, Jae hwan; Lee, Jeong Keun; Bae, Young Mee; Choi, Min Ho; Oh, Jin Kyoung; Lim, Min Kyung; Shin, Hai Rim; Hong, Sung Tae

doi:10.3347/kjp.2007.45.2.149

Cited by 18 publications

(20 citation statements)

References 13 publications

(9 reference statements)

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“…However, in humans, this is not always the case. No worms were recovered from three of eight infected humans with EPGs higher than 1,000 (Shen et al 2007). In experimental animals, worms can be recovered directly from the liver after sacrifice.…”

Section: Discussionmentioning

confidence: 94%

Early detection and estimation of infection burden by real-time PCR in rats experimentally infected with Clonorchis sinensis

et al. 2011

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A real-time PCR assay targeting the cytochrome c oxidase gene of Clonorchis sinensis was developed and its diagnostic value was investigated in experimentally infected rats. The PCR assay amplified as little as 0.1 pg of C. sinensis genomic DNA and a single egg from experimentally spiked negative feces. The assay could detect C. sinensis DNA in feces 2 weeks post-infection (PI), whereas the Kato-Katz method and formalin-ether concentration techniques could detect the eggs in the feces from 3 weeks PI. Inverse correlations between eggs per gram of feces (EPG) and Ct values were observed 4, 6, and 8 weeks PI. Worm burden was positively correlated with EPG but negatively correlated with Ct values in different groups at 8 weeks PI. Fecal real-time PCR provides a potential tool for the diagnosis of clonorchiosis before eggs can be detected by conventional methods, and may be used to estimate the worm burden in the host.

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Section: Discussionmentioning

confidence: 94%

Early detection and estimation of infection burden by real-time PCR in rats experimentally infected with Clonorchis sinensis

et al. 2011

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“…These CT findings differ from abscesses, which generally appear as areas of low attenuation and ascaris infection, in which CT generally demonstrates a hyperdense tubular structure inside the dilatated intrahepatic duct (8). Treatment for Clonorchis sinensis involves praziquantel (1,6,9). The dose that has been found to be most effective is 25 mg/kg three times a day over a single day.…”

Section: Discussionmentioning

confidence: 99%

“…Side effects of this treatment are minimal and well tolerated (1). Generally, after treatment the flukes become contracted and are passed through the gastrointestinal tract (1,9).…”

Section: Discussionmentioning

confidence: 99%

Oriental Cholangiohepatitis (Clonorchiasis Infestation) Caused by Clonorchis Sinensis

Klemencic

Phelan

Patrick

et al. 2012

The Journal of Emergency Medicine

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“…For diagnostic purposes a praziquantel treatment can be combined with purgatives. The diarrheic stools of patients were then examined for the presence of adult flukes [159].…”

Section: Diagnosismentioning

confidence: 99%

Opisthorchiidosis-A Review

Schuster

2010

IDDT

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The discovery history of opisthorchiid flukes dates back more than 200 years. The life cycle of these liver flukes includes prosobranch snails as the first and a big variety of freshwater fish as the second intermediate hosts. Opisthorchis felineus, O. viverrini and Clonorchis sinensis are species of major medical importance, while sporadic cases of human infection with other representatives of this family are also documented in the literature. There are estimations that 17 million people are infected and more than 350 million people are at risk, mainly in Asian countries. Although opisthorchiid flukes live in the bile ducts of the liver and in the gall bladder, they can affect surrounding liver tissue and even other organs. They are also known to induce the production of autoantibodies as well as allergic reactions. However, the main medical significance is their role in the formation of malignant tumors. Since the clinical symptoms are not specific, a diagnosis must be confirmed by parasitological examination or the detection of antibodies. Apart from coproscopical methods, there are more recent and highly specific assays available, like the detection of coproantigen or the detection of DNA. Praziquantel is the drug of choice for the treatment of opisthorchiidosis. In order to prevent infection, consumption of raw flesh of freshwater fish must be avoided.

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Collection of Clonorchis sinensis adult worms from infected humans after praziquantel treatment

Cited by 18 publications

References 13 publications

Early detection and estimation of infection burden by real-time PCR in rats experimentally infected with Clonorchis sinensis

Early detection and estimation of infection burden by real-time PCR in rats experimentally infected with Clonorchis sinensis

Oriental Cholangiohepatitis (Clonorchiasis Infestation) Caused by Clonorchis Sinensis

Opisthorchiidosis-A Review

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