Collecting duct carcinoma of the kidney: Disease characteristics and treatment outcomes from the National Cancer Database

Sui, Wilson; Matulay, Justin T.; Robins, Dennis; James, Maxwell B.; Onyeji, Ifeanyi; RoyChoudhury, Arindam; Wenske, Sven; DeCastro, G. Joel

doi:10.1016/j.urolonc.2017.04.010

Cited by 55 publications

(61 citation statements)

References 26 publications

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“…In our series, in contrast with what has been previously reported (12), a high proportion of patients (67.4%) were diagnosed as localized disease without symptoms; this may reflect the broader use of radiologic techniques and the incidental finding of renal masses that, in some cases, are ultimately resected and diagnosed as CDC. Our survival data are similar to the largest series published, which is the one by the National Cancer Institute (NCI), comparing the outcome of CDC with clear cell renal cell carcinoma (CCRCC) (13). In this database analysis, including 577 patients with CDC and 201.686 CCRCC from 2004 to 2013, the median OS of patients with CDC was 13.2 months (14 months in our group).…”

Section: Discussionsupporting

confidence: 77%

Collecting Duct Carcinoma of the Kidney: Analysis of Our Experience at the SPANISH ‘Grupo Centro’ of Genitourinary Tumors

Pinto¹,

Garrido

Aguado

et al. 2019

KCA

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Introduction: Collecting duct carcinomas (CDC), also known as Bellini's tumors, are a rare and aggressive subtype of renal cell carcinoma. Therefore, there are very few data about their management, and there is no standard therapy for this malignancy. We report the outcome of CDC patients treated on institutions belonging to the 'Grupo Centro' of Genitourinary Tumors, a novel networking cooperative group in Spain. Material and Methods: Patients with CDC diagnosed between 1995 and 2015 were included. They had to have an appropriate follow-up, as well as available tissue for further correlative studies. Demographic baseline features and therapy outcomes were collected in a retrospective fashion. Approval for this data collection was obtained from a central ethical committee. Results: A total of 43 patients were analysed, with a median overall survival (OS) of 14 months (95% CI: 9.2-18.8 months). 29 of them (67.4%) were diagnosed as localized disease, and 14 (32.6%) as metastatic disease. For the subgroup of patients diagnosed without metastases, median relapse-free survival (RFS) is 22 months (95% CI: 12.4-35.6 months), and median OS, 53 months (95% CI: 35.5-84.3 months). For the subgroup of patients with metastatic disease, median OS is 6 months (95% CI: 4.1-7.8 months). 16 patients (55.2%) with stage IV disease received systemic therapy, mainly platinum-based chemotherapy, with a response rate of 12.5% and a median progression-free survival (PFS) of 2 months. Conclusions: CDC of the kidney is a malignancy with poor prognosis and few responses to therapy. Median OS of our group in the metastatic setting is similar to what has been observed in previous series. There is a clear need to improve the armamentarium we have for the systemic approach of patients with advanced CDC.

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Section: Discussionsupporting

confidence: 77%

Collecting Duct Carcinoma of the Kidney: Analysis of Our Experience at the SPANISH ‘Grupo Centro’ of Genitourinary Tumors

Pinto¹,

Garrido

Aguado

et al. 2019

KCA

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“…[ 16 , 17 ] Patients with collecting duct histological type also had lower OS and CSS, possibly due to the frequent presence of metastasis (>70% of patients) at diagnosis. [ 18 ]…”

Section: Discussionmentioning

confidence: 99%

Marital status and survival in patients with renal cell carcinoma

Zhu

2018

Medicine

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Previous studies have shown that marital status is an independent prognostic factor for survival in several types of cancer. In this study, we investigated the effects of marital status on survival outcomes among renal cell carcinoma (RCC) patients.We identified patients diagnosed with RCC between 1973 and 2013 from the Surveillance, Epidemiology and End Results (SEER) database. Kaplan–Meier analysis and Cox regression were used to identify the effects of marital status on overall survival (OS) and cancer-specific survival (CSS).We enrolled 97,662 eligible RCC patients, including 64,884 married patients, and 32,778 unmarried (9831 divorced/separated, 9692 widowed, and 13,255 single) patients at diagnosis. The 5-year OS and CSS rates of the married, separated/divorced, widowed, and single patients were 73.7%, 69.5%, 58.3%, and 73.2% (OS), and 82.2%, 80.7%, 75.7%, and 83.3% (CSS), respectively. Multivariate Cox regression showed that, compared with married patients, widowed individuals showed poorer OS (hazard ratio, 1.419; 95% confidence interval, 1.370–1.469) and CSS (hazard ratio, 1.210; 95% confidence interval, 1.144–1.279). Stratified analyses and multivariate Cox regression showed that, in the insured and uninsured groups, married patients had better survival outcomes while widowed patients suffered worse OS outcomes; however, this trend was not significant for CSS.In RCC patients, married patients had better survival outcomes while widowed patients tended to suffer worse survival outcomes in terms of both OS and CSS.

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“…5 Sólo un estudio retrospectivo ha reportado disminución de la mortalidad cuando se complementa con cirugía en pacientes con metástasis. 2 Puesto que se trata de un tumor excepcional y el diagnóstico se establece en etapas avanzadas, le confiere un mal pronóstico. Un estudio de 41 casos pareados con carcinoma de células claras reportó una tasa de supervivencia similar a la de pacientes con carcinoma de conductos colectores de Bellini.…”

Section: Discussionunclassified

“…1 Según la cohorte más grande reportada por la National Cancer Database (NCDB), se estimó una incidencia de 0.2% y supervivencia media de 13.2 meses. 2 Su histogénesis corresponde a células de los conductos colectores en la médula renal. De acuerdo con su origen embriológico, el carcinoma de los conductos colectores se inicia en la yema ureteral y el carcinoma medular en el blastema metanéfrico.…”

Section: Antecedentesunclassified

Untitled

Álvarez

2018

Rev Mex Urol

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Paciente femenina de 77 años de edad, que inició su cuadro clínico con dolor en el flanco izquierdo, de 20 días de evolución, además de dolor óseo. El ultrasonido reportó una masa dependiente del polo superior del riñón izquierdo. La tomografía simple, complementada con resonancia magnética, evidenció una lesión de 5.7 x 7.3 cm, de consistencia sólida, con necrosis central y extensión hacia el seno renal (T2a; GII). El tratamiento consistió en nefrectomía radical laparoscópica izquierda. Se estableció el diagnóstico de carcinoma de conductos colectores de Bellini. El seguimiento a 5 meses mostró un nuevo ganglio latero-aórtico izquierdo de 16 mm. Se realizó escisión de la lesión y linfadenectomía retroperitoneal, que reportó 20 ganglios con hiperplasia linfoide negativa a malignidad. Treinta y nueve meses después de la nefrectomía, la tomografía computada evidenció dos tumores retroperitoneales: uno paraaórtico y otro intercavoaórtico, compatibles con recurrencia de la enfermedad. Se llevó a cabo metastasectomía, que histopatológicamente reportó un tumor sólido, irregular, de color blanco-grisáceo, con áreas extensas de hemorragia en su porción inferior izquierda y focos discretos de necrosis. Hoy día, después de 42 meses de seguimiento, la paciente se mantiene en vigilancia y sin datos de recurrencia. CONCLUSIONES: El carcinoma de conductos colectores es una neoplasia excepcional. El caso aquí reportado corresponde al de mayor supervivencia y tiempo de recurrencia descrito en un caso de T2M0 sintomático: 39 meses.

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Collecting duct carcinoma of the kidney: Disease characteristics and treatment outcomes from the National Cancer Database

Cited by 55 publications

References 26 publications

Collecting Duct Carcinoma of the Kidney: Analysis of Our Experience at the SPANISH ‘Grupo Centro’ of Genitourinary Tumors

Collecting Duct Carcinoma of the Kidney: Analysis of Our Experience at the SPANISH ‘Grupo Centro’ of Genitourinary Tumors

Marital status and survival in patients with renal cell carcinoma

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