Collecting duct carcinoma of kidney: Masquerading as genitourinary tuberculosis - Lessons learnt

Mathisekaran, T; Raghavan, Deepak; Muthu, Ranjanee; Prabhakar, Vikram; Prakash, Swayam

doi:10.1016/j.eucr.2019.101100

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…The clinical symptoms of CDCK vary according to tumor size, location, and invasion. Some patients are diagnosed by physical examination because they have no symptoms ( 15 ), whereas other patients are diagnosed with symptoms at the site of metastasis ( 16 , 17 ). Unfortunately, the absence of information on symptoms in the database prevented us from understanding the characteristics of patients’ symptoms in the present study.…”

Section: Discussionmentioning

confidence: 99%

Incidence, Clinical Characteristics, and Survival of Collecting Duct Carcinoma of the Kidney: A Population-Based Study

Tang

Zhou

et al. 2021

Front. Oncol.

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ObjectiveTo investigate the exact age‐adjusted incidence (AAI), clinical characteristics, and survival data of collecting duct carcinoma of the kidney (CDCK) recorded in the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute.MethodsPatients with CDCK confirmed by microscopic examination from 2004 to 2018 were selected from the SEER database. AAI rates were calculated using SEER*Stat software (version 8.3.9). The Kaplan‐Meier method was used to evaluate cancer-specific survival (CSS) rates according to tumor size, tumor stage, and treatment methods, and differences among these variables were assessed by the log‐rank test. Cox regression analysis was employed to identify variables independently related to CSS.ResultsA total of 286 patients with CDCK were identified from the database. The majority of the patients were white (69.2%), male (67.5%), and married (60.5%), and the median age was 59 years. Most patients with CDCK (74.4%) presented with stages III or IV disease. The diameter of most (59.4%) tumors was less than 7 cm, and the tumors were more commonly found on the left than on the right (55.2% vs. 44.8%). The incidence of CDCK decreased over time. The median CSS time was 17 months. In terms of the treatment modalities used, 83.9% of the patients underwent surgery; 32.9% underwent chemotherapy, and 13.6% underwent radiotherapy. The CSS rates at 1, 2, and 5 years were 57.3%, 43.2%, and 30.7%, respectively. In patients with stage IV CDCK treated with surgery alone, chemotherapy alone, and surgery plus chemotherapy, the median survival time was 5 months, 9 months, and 14 months, respectively (P =0.024). Multivariate Cox regression analysis showed surgery, chemotherapy, stage, regional lymph node metastasis, and distant metastasis were independent prognostic factors for patients with CDCK.ConclusionsCDCK is an uncommon malignant renal carcinoma, and its incidence is decreasing based on the analysis of current data. CDCK is a high stage, regional lymph-nodes positive, and metastatic disease. Compared with surgery alone or chemotherapy alone, patients with stage IV could gain survival benefit from surgery combined with chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Incidence, Clinical Characteristics, and Survival of Collecting Duct Carcinoma of the Kidney: A Population-Based Study

Tang

Zhou

et al. 2021

Front. Oncol.

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“…The lung is the most common site (57%), followed by lymph nodes (48%) and osteoblastic bony metastasis. 4 The Patient, in this case, was presented by non-specific pulmonary symptoms manifested as cough and dyspnea. Metastasis was suggested by radiology in lung and bone after the detection of a large kidney mass.…”

Section: Discussionmentioning

confidence: 93%