2016
DOI: 10.1002/brb3.513
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Collateral state and the effect of endovascular reperfusion therapy on clinical outcome in ischemic stroke patients

Abstract: PurposeClinically successful endovascular therapy (EVT) in ischemic stroke requires reliable noninvasive pretherapeutic selection criteria. We investigated the association of imaging parameters including CT angiographic collaterals and degree of reperfusion with clinical outcome after EVT.MethodsIn our database, we identified 93 patients with large vessel occlusion in the anterior circulation treated with EVT. Besides clinical data, we assessed the baseline Alberta Stroke Program Early CT score (ASPECTS) on no… Show more

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Cited by 28 publications
(28 citation statements)
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“…Although the effect of earlier time to thrombolytic treatment on outcome is indisputable from the pooled RCT analyses ( 19 ), our data suggest that infarct core volume and collateral grade are likely to be several orders of magnitude greater in influencing the probability of a good outcome following rtPA treatment. These results are in line with those of endovascular patients where time to revascularization has been shown to be of less importance in comparison to other advanced imaging measures for patient treatment suitability ( 20 ).…”
Section: Discussionsupporting
confidence: 85%
“…Although the effect of earlier time to thrombolytic treatment on outcome is indisputable from the pooled RCT analyses ( 19 ), our data suggest that infarct core volume and collateral grade are likely to be several orders of magnitude greater in influencing the probability of a good outcome following rtPA treatment. These results are in line with those of endovascular patients where time to revascularization has been shown to be of less importance in comparison to other advanced imaging measures for patient treatment suitability ( 20 ).…”
Section: Discussionsupporting
confidence: 85%
“…The duration of thrombolysis treatment was 3–6 h in 12 studies and >6 h in 5 studies, extending up to 12 h. However, the time window was not prescribed in 6 of the studies. The assessment of the pre-treatment collateral circulation status was performed using different imaging methods, which were computed tomography (CT) angiography in 22 studies ( 7 , 8 , 12 , 14 , 15 , 17 , 18 , 22 35 , 37 ), while others included digital subtraction angiography ( 13 , 36 ), fluid-attenuated inversion recovery imaging ( 19 , 21 ), and CT or magnetic resonance perfusion imaging ( 16 , 20 , 38 ) ( Table I ).…”
Section: Resultsmentioning
confidence: 99%
“…During the study period, we performed aspiration thrombectomy in about two thirds and stent retriever thrombectomy with distal aspiration in one third of the patients. 18…”
Section: Methodsmentioning
confidence: 99%