Collateral Projections from the Medullary Dorsal Horn to the Ventral Posteromedial Thalamic Nucleus and the Parafascicular Thalamic Nucleus in the Rat

Li, Jiani; Sun, Yi; Ji, Songling; Chen, Yanbing; Ren, Jia-Hao; He, Cheng-Bo; Wu, Zhenyu; Li, Hui; Dong, Yu-Lin; Li, Yunqing

doi:10.1016/j.neuroscience.2019.04.050

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“…The number of 5-HT neurons was reduced in the DRN and accompanied by a reduction in 5-HT expression in the thalamus, ACC and amygdala. These regions were selected because they mediate descending modulation of pain and receive 5-HT input from the DRN (Ab Aziz and Ahmad, 2006;Chao et al, 2021;Duan et al, 2021;Gandhi et al, 2021;Gilpin et al, 2021;Heijmans et al, n.d.;Juarez-Salinas et al, 2019;Li et al, 2019;Price, 2000;Zargarani et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood

Khan

Rosa

Biggerstaff

et al. 2023

Brain, Behavior, and Immunity

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Section: Discussionmentioning

confidence: 99%

Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood

Khan

Rosa

Biggerstaff

et al. 2023

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood

Khan

Rosa

Biggerstaff

et al. 2021

Preprint

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Adolescent alcohol use can permanently alter brain function and lead to poor health outcomes in adulthood. Emerging evidence suggests that alcohol use predispose to pain disorders or exacerbate existing pain conditions, but the neural mechanisms are currently unknown. Here we report that mice exposed to adolescent intermittent access to ethanol (AIE) exhibit increased pain sensitivity and depressive-like behaviors that persist after alcohol cessation and are accompanied by elevated CD68 expression in microglia and reduced numbers of serotonin (5-HT)-expressing neurons in the dorsal raphe nucleus (DRN). 5-HT expression was also reduced in the thalamus, anterior cingulate cortex (ACC) and amygdala as well as the lumbar dorsal horn of the spinal cord. We then found that chronic minocycline administration after AIE alleviated hyperalgesia and social deficits, while chemogenetic activation of microglia in the DRN of Cx3cr1-cre-GFP mice reproduced the effects of AIE on pain and social interaction. Taken together, these results indicate that microglial activation in the DRN may be a primary driver of pain and negative affect after AIE.

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Collateral Projections from the Medullary Dorsal Horn to the Ventral Posteromedial Thalamic Nucleus and the Parafascicular Thalamic Nucleus in the Rat

Cited by 2 publications

References 47 publications

Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood

Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood

Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood

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