Collateral Circulation Following Experimental Gradual Narrowing of the Coronary Arteries

Lumb, George; Singletary, Henry P.; Hardy, Lawrence B.

doi:10.1177/000331976201301004

Cited by 23 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…76, No. 2 (1981) or gradually occluded (3,4,5,8), show that mortality following such occlusion may be nearly 50 %, with some salvage of the myocardium observed. An increased collateral supply in these hearts was documented by injection techniques, increased peripheral coronary pressure, or increased retrograde flow (3,4,5,8).…”

Section: Discussionmentioning

confidence: 99%

“…2 (1981) or gradually occluded (3,4,5,8), show that mortality following such occlusion may be nearly 50 %, with some salvage of the myocardium observed. An increased collateral supply in these hearts was documented by injection techniques, increased peripheral coronary pressure, or increased retrograde flow (3,4,5,8). These investigators also concluded that some infarction almost occurs after occlusion in the pig, even when occlusion is induced gradually with an ameroid occluder (3,4,5,8).…”

Section: Discussionmentioning

confidence: 99%

“…When using the pig as a model of myocardial ischemia or infarction, a knowledge of its coronary collateral circulation is critical for interpretation of such studies. The pig has been used in studies when there is a need for a model with uniform coronary anatomy similar to that of man (3) and naturally occurring interarterial anastomoses less than 50 ~ in size (4). In the pig collateral vessels are exclusively endomural and subendocardial (5) and may be similar to those of man (6).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Coronary collateral circulation in the pig: correlation of collateral flow with coronary bed size

1981

View full text Add to dashboard Cite

Coronary bed sizes were measured in pigs. The left anterior descending bed occupies about 31% of the heart, the right coronary bed about 38% of the heart and the left circumflex bed about 31% of the heart is (including atria). The right coronary artery supplies about 81% of the right ventricle and 23% of the left ventricle with its blood supply. The remaining portion of the right ventricle is supplied by the LAD. The collateral circulation was measured in each of the 3 coronary beds using tracer microspheres. Measurements, are in ml/min/100 g. Transmural collateral flow in the LC is 5.6, the LAD 1.0, the RC in LV 3.7 and the RC in RV 4.3. Our experiments showed that the coronary bed sizes were relatively uniform in pigs, but that collateral flow was significantly different between the beds.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Coronary collateral circulation in the pig: correlation of collateral flow with coronary bed size

1981

View full text Add to dashboard Cite

show abstract

“…This variation is reflected by the level of collateral-dependent blood flow following acute occlusion, and with the functional consequences of acute occlusion. Thus, it was soon observed that while acute coronary ligation is generally lethal in pigs (553, 554), which have sparse collaterals, it is somewhat less so in dogs (143), which have abundant collaterals. In a comparative study of eight species, Maxwell and coworkers found that collateral flow to acutely ischemic myocardium (as a percentage of normal blood flow) ranged from a high of 15.9% in dogs (excepting guinea pigs, which showed no impairment of flow following acute occlusion) to a low of 0.6% in pigs (592).…”

Section: Training Adaptations Within the Active Muscle: Increasedmentioning

confidence: 99%

Exercise Training and Peripheral Arterial Disease

Haas

Lloyd

Yang

et al. 2012

Comprehensive Physiology

119

108

View full text Add to dashboard Cite

Peripheral arterial disease (PAD) is a common vascular disease that reduces blood flow capacity to the legs of patients. PAD leads to exercise intolerance that can progress in severity to greatly limit mobility, and in advanced cases leads to frank ischemia with pain at rest. It is estimated that 12–15 million people in the United States are diagnosed with PAD, with a much larger population that is undiagnosed. The presence of PAD predicts a 50–1500% increase in morbidity and mortality, depending on severity. Treatment of patients with PAD is limited to modification of cardiovascular disease risk factors, pharmacological intervention, surgery, and exercise therapy. Extended exercise programs that involve walking ~5 times/wk, at a significant intensity that requires frequent rest periods, are most significant. Pre-clinical studies and virtually all clinical trials demonstrate the benefits of exercise therapy, including: improved walking tolerance, modified inflammatory/hemostatic markers, enhanced vasoresponsiveness, adaptations within the limb (angiogenesis, arteriogenesis, mitochondrial synthesis) that enhance oxygen delivery and metabolic responses, potentially delayed progression of the disease, enhanced quality of life indices, and extended longevity. A synthesis is provided as to how these adaptations can develop in the context of our current state of knowledge and events known to be orchestrated by exercise. The benefits are so compelling that exercise prescription should be an essential option presented to patients with PAD in the absence of contraindications. Obviously, selecting for a life style pattern, that includes enhanced physical activity prior to the advance of PAD limitations, is the most desirable and beneficial.

show abstract

“…A dry cuff placed in saline halves its lumen in 16 days but this period can be prolonged by pretreating the Ameroid with petrolatum jelly. Several studies have been carried out with this model (Vineberg et al, 1960;Lumb et al, 1962;Peter et al, 1966). Mortality is quite high (Peter et al, 1966) and the degree of myocardial necrosis produced varies considerably.…”

Section: Combination Of Open-and Closed-chest Methodsmentioning

confidence: 99%

Animal models of myocardial ischaemia.

Woolf¹

1977

Journal of Clinical Pathology

View full text Add to dashboard Cite

Collateral Circulation Following Experimental Gradual Narrowing of the Coronary Arteries

Cited by 23 publications

References 0 publications

Coronary collateral circulation in the pig: correlation of collateral flow with coronary bed size

Coronary collateral circulation in the pig: correlation of collateral flow with coronary bed size

Exercise Training and Peripheral Arterial Disease

Animal models of myocardial ischaemia.

Contact Info

Product

Resources

About