Collapsin Response Mediator Protein 4 Expression is Associated with Liver Metastasis and Poor Survival in Pancreatic Cancer

Abstract

Our results suggested that CRMP4 is significantly associated with poor prognosis by promoting liver metastasis and can serve as a novel therapeutic target for pancreatic cancer.

Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review)

“…The biological function of CRMP4 has also been reported in pancreatic cancer, by Hiroshima et al (51). Of all the CRMP family members (CRMP1-5), only CRMP4 expression was found to significantly increase in pancreatic cancer compared with the corresponding non-cancerous pancreas tissues.…”

Dihydropyrimidinase-like 3 is a putative hepatocellular carcinoma tumor suppressor

“…DPYSL3 and VEGF expression levels correlate inversely, which reflects the stimulatory effects of their encoded proteins on the migration of tumor cells and interaction with other cell adhesion molecules [22][23][24]. Evidence indicates that DPYSL3 acts as an oncogene or tumor suppressor gene in prostate and pancreatic cancer, respectively [22,24].…”

“…Expression of genes that encode potential binding partners of DPYSL3 VEGF, EZR, FAK and SRC encode proteins that may interact with DPYSL3 [22][23][24]. Therefore, we used qRT-PCR to determine their levels of expression in HCC cell lines and 151 clinical samples.…”

“…For example, Gao et al reported that inhibiting DPYSL3 expression enhances the metastatic growth of pancreatic cancer cells and that DPYSL3 expression inversely correlates with that of vascular endothelial growth factor (VEGF), indicating that DPYSL3 encodes a metastasis suppressor [22]. In contrast, Kawahara et al concluded that DPYSL3 stimulates the migration of pancreatic tumor cells and interacts with other cell adhesion molecules such as ezrin (EZR), focal adhesion kinase (FAK), and SRC [23,24]. These reports motivated us to determine whether DPYSL3 acts as a tumor suppressor gene or an oncogene in HCC.…”

Caerulein‐induced pancreatitis augments the expression and phosphorylation of collapsin response mediator protein 4

“…The CRMP family comprises five cytosolic phosphoproteins, CRMP1, CRMP2, CRMP3, CRMP4, and CRMP5. Pancreatic cancer cells frequently have enhanced CRMP4 expression that strongly correlates with severe venous invasion, liver metastasis, and poor prognosis .…”