2001
DOI: 10.1093/jnci/93.18.1392
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Collapsin Response Mediator Protein-1 and the Invasion and Metastasis of Cancer Cells

Abstract: CRMP-1 appears to be involved in cancer invasion and metastasis and may be an invasion-suppressor gene.

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Cited by 145 publications
(149 citation statements)
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References 58 publications
(69 reference statements)
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“…17,18 As shown in Figure 1A, expression of caveolin-1 protein in the low-invasive CL1-0 and CL1-1 cells was undetectable. In contrast, it was abundantly expressed in the highly invasive CL1-5 and CL1-5F4 cells.…”
Section: Elevated Caveolin-1 Expression In CL Cells Correlated With Ementioning
confidence: 94%
“…17,18 As shown in Figure 1A, expression of caveolin-1 protein in the low-invasive CL1-0 and CL1-1 cells was undetectable. In contrast, it was abundantly expressed in the highly invasive CL1-5 and CL1-5F4 cells.…”
Section: Elevated Caveolin-1 Expression In CL Cells Correlated With Ementioning
confidence: 94%
“…The specific rabbit anti-human anti-LCRMP-1 polyclonal antibody (C2) for western blotting and IHC was produced by the authors using a synthetic peptide derived from the unique N-terminal region of LCRMP-1, as described previously (6). Formalin-fixed, paraffin-embedded sections (5-µm thick) were processed for IHC.…”
Section: Immunohistochemistry (Ihc)mentioning
confidence: 99%
“…CRMP-1 has been observed to be a cancer invasion suppressor (6). In addition, a negative association between CRMP-1 expression and cancer cell invasiveness has been observed in non-small cell lung cancer (NSCLC) patients (7).…”
Section: Introductionmentioning
confidence: 99%
“…77,79 Lung cancer cell line A549 was purchased from Bioresource Collection and Research Center (BCRC), Taiwan. A complete medium composed of Dulbecco's Modified Eagle's medium (DMEM, Gibco) and 10% fetal bovine serum (FBS, Invitrogen) was used for all cells.…”
Section: Cell Preparationmentioning
confidence: 99%
“…The size of the chamber and thus the medium consumption are largely reduced. The electrotaxis effect of human lung cell lines, A549, CL1-0, and CL1-5, [77][78][79] in 3D scaffolds was observed and compared with that studied in 2D gelatin-coated and bare substrates. 9 …”
Section: Introductionmentioning
confidence: 99%