This paper presents an experimental investigation of the effect of load path on force-displacement response, damage patterns and failure modes of slender lightly-reinforced concrete columns. A review of available experimental tests that include columns subjected to multi-axial loading protocols is first presented. Next, a new experimental campaign on 18 column specimens tested under constant axial load and lateral displacementcontrolled load paths is described. The results of the tests performed confirm that the response under biaxial load paths is qualitatively and quantitatively different from that observed for uniaxial load paths. The first and foremost qualitative difference is that the damage mechanisms change and the failure mode can change as a result. This, in turn, leads to the quantitative differences in ultimate and collapse deformation, and therefore ductility and hysteretic dissipation capacity.