Collagenous enterocolitis and maturity onset type 1 diabetes manifesting as uraemia, malabsorption and extreme weight loss

Hunter, Jonathan; Lee, Hui Jean; Dettrick, Andrew; Tan, Chee Eng

doi:10.1136/bcr-2013-200409

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…Symptoms consist of chronic watery diarrhoea and a considerable number of patients suffer with abdominal pain, nocturnal symptoms and weight loss. Diarrhoea symptoms often follow a chronic relapsing and remitting course 4 5. Although a chronic disease, severe complications are infrequent, with only few cases of colonic perforations reported 6 7.…”

Section: Discussionmentioning

confidence: 99%

“…This is likely explained by the predominant changes of collagenous colitis, which tends to affect the proximal colon, which is the main site of action of budesonide. There are no clinical trials examining the utility of budesonide for panenteric collagen deposition apart from collagenous colitis 4. Miehlke et al 5 in their multicentre, randomised controlled trial did demonstrate that budesonide had better clinical and histological remission rates than mesalazine and placebo at week 8.…”

Section: Discussionmentioning

confidence: 99%

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Collagenous panenteritis: a rare cause of chronic diarrhoea

Singh

Loo

Watters

et al. 2017

Frontline Gastroenterol

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Collagenous panenteritis is a rare inflammatory condition that causes profound diarrhoea and weight loss. There has only been a handful of cases reported in the literature. We report this rare case and the diagnostic difficulties encountered in securing the diagnosis. A 59-year-old woman presented with an 8-month history of diarrhoea and weight loss on a background of a family history of coeliac disease. Her presentation was complicated with acute kidney injury secondary to prerenal losses. Repeated gastroscopies and colonoscopies along with biopsies were inconclusive. It was not until histology of biopsies taken at endoscopies were reviewed that a diagnosis of collagenous panenteritis was secured. Her management revolved around combination of budesonide, gluten-free diet and antidiarrhoeals, which has achieved clinical remission.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Collagenous panenteritis: a rare cause of chronic diarrhoea

Singh

Loo

Watters

et al. 2017

Frontline Gastroenterol

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“…Serological testing5 8 and human leucocyte antigen typing9 for CD may be positive in some cases of CS. GFD alone is usually ineffective for the treatment of CS, which often requires corticosteroids 1.…”

Section: Discussionmentioning

confidence: 99%

Collagenous enterocolitis manifesting as watery diarrhoea and iron-deficiency anaemia

Yau

Xiong

2015

BMJ Case Reports

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A 56-year-old Caucasian woman presented with epigastric pain, watery diarrhoea, bloating and flatulence following treatment with duloxetine and venlafaxine for anxiety and depression. Abdominal examination was benign. Blood work revealed haemoglobin of 96 g/L (115–160 g/L), iron 6 μmol/L (10–33 μmol/L), transferrin saturation 0.08 (0.20–0.55), ferritin 26 μg/L (15–180 μg/L), albumin 46 g/L (35–50 g/L), pre-albumin 293 mg/L (170–370 mg/L), total IgA 2.64 g/L (0.78–3.58 g/L) and anti-tTG IgA 5 units (<20 units). Faecal occult blood tests were 3/3 positive and stool cultures were negative. CT enterography was normal. Colonic biopsy revealed collagenous colitis, while duodenal biopsy showed collagenous sprue with blunted to completely flattened villi and markedly thickened subepithelial collagen table entrapping capillaries and lymphocytes. The patient started a gluten-free diet, loperamide and ferrous gluconate. Her symptoms resolved and a faecal immunochemical test performed 6 months later was negative.

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Cyanosis Due to Methemoglobinemia as the Presenting Sign of Glucose-6-Phosphate Dehydrogenase Deficiency in a Child: Diagnostic and Clinical Implications

Pomoni¹,

Aggeli

Loutsi

et al. 2020

Journal of Pediatric Hematology/Oncology

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A previously healthy 3-year-old boy presented with pallor, jaundice, cyanosis, and a 24-hour history of vomiting and anorexia following fava bean ingestion. Clinical examination and laboratory findings were consistent with severe nonimmune hemolytic anemia with methemoglobinemia. Given the patient’s history, a previously unrecognized glucose-6-phosphate dehydrogenase deficiency was suspected and diagnosed. The aim of this article is to delineate the possible coexistence of methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency in children presented with acute hemolysis and discuss its management while reviewing the existing literature.

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Collagenous enterocolitis and maturity onset type 1 diabetes manifesting as uraemia, malabsorption and extreme weight loss

Cited by 3 publications

References 36 publications

Collagenous panenteritis: a rare cause of chronic diarrhoea

Collagenous panenteritis: a rare cause of chronic diarrhoea

Collagenous enterocolitis manifesting as watery diarrhoea and iron-deficiency anaemia

Cyanosis Due to Methemoglobinemia as the Presenting Sign of Glucose-6-Phosphate Dehydrogenase Deficiency in a Child: Diagnostic and Clinical Implications

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