Collagenous colitis associated with small intestinal villous atrophy.

Hamilton, I.; Sanders, Sue S.; Hopwood, David A.; Bouchier, I. A. D.

doi:10.1136/gut.27.11.1394

Cited by 70 publications

(29 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Identification of ileal inflammation may be significant in distinguishing certain inflammatory conditions such as ulcerative colitis and Crohn disease. Prior studies of lymphocytic and collagenous colitis have identified abnormal findings in the duodenum (13,14) and jejunum (15)(16)(17)(18)(19), but only a few studies have described the changes in the mucosa of the terminal ileum (1, 7, 12, 20 -24). In these studies, the terminal ileum has been shown to have normal morphological features (1,12) or to demonstrate variable degrees of villous atrophy (7,21,23,24) with or without thickening of the subepithelial collagen table (20, 22; Table: 1).…”

mentioning

confidence: 99%

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Padmanabhan

Callas

et al. 2003

Modern Pathology

View full text Add to dashboard Cite

Biopsy specimens from the terminal ileum of 32 patients with the histopathological diagnosis of lymphocytic colitis or collagenous colitis and 11 control individuals were evaluated for the presence or absence of ileal mucosal abnormalities and for the number of intraepithelial lymphocytes, assessed by immunohistochemical stains for the pan T-cell marker, CD3. We found that the mean CD3 counts in patients with lymphocytic/collagenous colitis were significantly higher than those in the control group. Seven of 14 patients with collagenous colitis and 14 of 18 patients with lymphocytic colitis revealed an increase in intraepithelial T lymphocytes when compared with the control group (P ‫؍‬ .001). Other notable changes included ileal villous atrophy in one case of lymphocytic colitis and in three cases of collagenous colitis and epithelial damage with thickened subepithelial collagen in two cases of collagenous colitis.

show abstract

mentioning

confidence: 99%

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Padmanabhan

Callas

et al. 2003

Modern Pathology

View full text Add to dashboard Cite

show abstract

“…The histologic findings of intraepithelial lymphocytic infiltrates and epithelial injury throughout the gastric and intestinal biopsy material and the serologic presence of several autoantibodies, including antigliadin, antiendomysial, and pANCA, are unifying features. Recently, reports have shown overlap of both related and seemingly (17,(21)(22)(23)(24)(25). Associated clinical and pathologic features of these chronic inflammatory bowel diseases suggest overlapping causes or a similar pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Collagenous Gastritis: A Case Report, Morphologic Evaluation, and Review

et al. 2000

View full text Add to dashboard Cite

Collagenous gastritis is rare; there are only four previous case reports. Histologic features seem to overlap with the other "collagenous enterocolitides"; however, pathologic criteria are not yet established for the diagnosis of collagenous gastritis. We describe an additional case of ostensible collagenous gastritis in a patient who initially presented with celiac sprue and subsequently developed colonic manifestations of mucosal ulcerative colitis. Endoscopic biopsies of the stomach revealed deposition of patchy, very thick bandlike subepithelial collagen in gastric antral mucosa, focal superficial epithelial degeneration, numerous intraepithelial lymphocytes, and a dense lamina propria lymphoplasmacytic infiltrate. Image analysis evaluation of gastric antral biopsies demonstrated a mean thickness of subepithelial collagen of 27.07 . Morphologic comparison was made with age-matched control groups of 10 patients who had normal gastric mucosal biopsies and 10 patients who had "chronic" gastritis, which revealed mean subepithelial collagen measures of 1.37 and 1.19 , respectively. We compared these morphologic findings with those of all previous case reports of collagenous gastritis and propose a pathologic definition based on the limited combined data. It seems that subepithelial collagen is dramatically thickened in reported cases of collagenous gastritis, with a cumulative mean measure of 36.9 . ⌱t is also apparent from this and previous reports that the thickened subepithelial collagen is accompanied by a chronic or chronic active gastritis and sometimes intraepithelial lymphocytes and surface epithelial damage. Recently described associations of lymphocytic gastritis, sprue, and lymphocytic colitis as well as collagenous and lymphocytic colitis suggest a common pathogenesis that empirically may include collagenous gastritis in the same disease spectrum. We propose that collagenous gastritis can be confidently identified by using analogous defined features of collagenous colitis: subepithelial collagen more than 10 in a patchy distribution, lamina propria lymphoplasmacytic infiltrates, intraepithelial lymphocytes, and surface epithelial damage. Collagenous gastritis also seems to have the same spectrum of associated clinical findings as collagenous colitis, including frequent coexistence of celiac sprue, watery diarrhea syndrome, and female predominance.

show abstract

“…Firstly, the collagenous band-like deposition is an uneven and discontinuous process along the length of the colon, and it is found more frequently in the proximal colon than in the rectosigmoid [24,27]. There are also variations in thickness of the collagenous band-like deposit at different levels of the colon.…”

Section: Histopathological Features (Recognizable and Recognized)mentioning

confidence: 97%

“…In 1986, the first three cases of collagenous colitis, coexisting with small intestinal villous atrophy [24,25] and the first autopsy case [49] were reported.…”

Section: The Years Of Progress and Controversy (1986-1993)mentioning

confidence: 99%

Collagenous, microscopic and lymphocytic colitis. An evolving concept

Bogomoletz

1994

Vichows Archiv A Pathol Anat

View full text Add to dashboard Cite

Collagenous colitis and lymphocytic colitis (previously described as microscopic colitis) are two newly recognised forms of colitis. Both have generated much controversy and continue to do so; their aetiology and pathogenesis are unresolved and their association with a variety of immune-related disorders is intriguing. Response to available therapeutic modalities is often disappointing. The possible relationship or overlap between these two conditions remains a controversial issue. The aim of this review is essentially to present an overview of collagenous colitis and lymphocytic colitis and to propose an unifying concept with an adapted terminology.

show abstract

Collagenous colitis associated with small intestinal villous atrophy.

Cited by 70 publications

References 12 publications

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Collagenous Gastritis: A Case Report, Morphologic Evaluation, and Review

Collagenous, microscopic and lymphocytic colitis. An evolving concept

Contact Info

Product

Resources

About