Collagenoma in a Patient With Down Syndrome: A Case Report and Review of the Literature

Choi, Sun Young; Park, Sanghui

doi:10.1097/dad.0000000000000873

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Six case reports presenting patients with DS having collagenomas or connective tissue nevi were included, with a mean age of 22.8 (SD 14.9) years [30,95,[103][104][105][106]. No history of trauma was reported.…”

Section: Connective Tissue Nevimentioning

confidence: 99%

Common Dermatologic Disorders in Down Syndrome: Systematic Review

Lam¹,

Lu²,

Elhadad³

et al. 2022

JMIR Dermatol

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Background Down syndrome (DS) has been associated with cardiovascular, gastrointestinal, and immune-related abnormalities. Several dermatologic conditions, including hidradenitis suppurativa, have also been found to be associated with DS. Objective The objective of this study was to characterize the prevalence, presentation, and unique features of dermatologic disorders associated with DS. Methods Electronic searches of EMBASE (via Ovid), MEDLINE (via Ovid), and Web of Science databases were conducted on December 14, 2020. Observational studies including case reports of patients with DS presenting with concomitant primary dermatologic disorder were included. Results This systematic review captured 40 observational studies and 99 case reports, including 10 observational studies that examined the prevalence of common skin disorders in patients with DS. The most common dermatologic conditions reported includes atopic dermatitis (8 studies, n=180; 19.7% mean prevalence), hidradenitis suppurativa (15, n=478; 3.2%), ichthyosis (4, n=16; 4.7%), lichen nitidus (6, n=6; 1.1%), psoriasis (21, n=65; 4.8%), alopecia areata (27, n=253; 7.4%), vitiligo (8, n=40; 4.4%), onychomycosis (3, n=198; 24.7%), calcinosis cutis (14, n=15), connective tissue nevi (6, n=6), dermatofibroma (3, n=3), melanoma (3, n=3), syringomas (14, n=182; 21.2%), and elastosis perforans serpiginosa (19, n=24; 0.5%). Conclusions Our results indicate an increased prevalence of common cutaneous disorders in patients with DS, particularly infectious, inflammatory, autoimmune, and connective tissue conditions. Current guidelines for the screening, general management, and use of systemic immunomodulatory agents in this patient population are lacking. Patients with DS would benefit from screening for dermatologic disorders not otherwise regularly performed for earlier diagnosis and treatment. Trial Registration PROSPERO International Prospective Register of Systematic Reviews CRD42021226295; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=226295

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Section: Connective Tissue Nevimentioning

confidence: 99%

Common Dermatologic Disorders in Down Syndrome: Systematic Review

Lam¹,

Lu²,

Elhadad³

et al. 2022

JMIR Dermatol

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Eruptive collagenoma in a juvenile patient with Down syndrome

Kato

Yamamoto

2022

Anais Brasileiros de Dermatologia

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Common Dermatologic Disorders in Down Syndrome: Systematic Review (Preprint)

Lam¹,

Lu²,

Elhadad³

et al. 2021

Preprint

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BACKGROUND Down syndrome (DS) has been associated with cardiovascular, gastrointestinal, and immune-related abnormalities. Several dermatologic conditions, including hidradenitis suppurativa, have also been found to be associated with DS. OBJECTIVE The objective of this study was to characterize the prevalence, presentation, and unique features of dermatologic disorders associated with DS. METHODS Electronic searches of EMBASE (via Ovid), MEDLINE (via Ovid), and Web of Science databases were conducted on December 14, 2020. Observational studies including case reports of patients with DS presenting with concomitant primary dermatologic disorder were included. RESULTS This systematic review captured 40 observational studies and 99 case reports, including 10 observational studies that examined the prevalence of common skin disorders in patients with DS. The most common dermatologic conditions reported includes atopic dermatitis (8 studies, n=180; 19.7% mean prevalence), hidradenitis suppurativa (15, n=478; 3.2%), ichthyosis (4, n=16; 4.7%), lichen nitidus (6, n=6; 1.1%), psoriasis (21, n=65; 4.8%), alopecia areata (27, n=253; 7.4%), vitiligo (8, n=40; 4.4%), onychomycosis (3, n=198; 24.7%), calcinosis cutis (14, n=15), connective tissue nevi (6, n=6), dermatofibroma (3, n=3), melanoma (3, n=3), syringomas (14, n=182; 21.2%), and elastosis perforans serpiginosa (19, n=24; 0.5%). CONCLUSIONS Our results indicate an increased prevalence of common cutaneous disorders in patients with DS, particularly infectious, inflammatory, autoimmune, and connective tissue conditions. Current guidelines for the screening, general management, and use of systemic immunomodulatory agents in this patient population are lacking. Patients with DS would benefit from screening for dermatologic disorders not otherwise regularly performed for earlier diagnosis and treatment. CLINICALTRIAL PROSPERO International Prospective Register of Systematic Reviews CRD42021226295; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=226295

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Collagenoma in a Patient With Down Syndrome: A Case Report and Review of the Literature

Cited by 3 publications

References 12 publications

Common Dermatologic Disorders in Down Syndrome: Systematic Review

Common Dermatologic Disorders in Down Syndrome: Systematic Review

Eruptive collagenoma in a juvenile patient with Down syndrome

Common Dermatologic Disorders in Down Syndrome: Systematic Review (Preprint)

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