Collagenofibrotic glomerulopathy in a young cat

Abstract

Collagenofibrotic glomerulopathy, also named collagen III glomerulopathy, is a rare glomerulopathy type caused by deposition of collagen III in the glomerular mesangium and subendothelial space. The aetiology of this entity is unknown and the pathological mechanism remains poorly understood. It is mostly seen in humans in Asian countries, especially in Japan. Collagenofibrotic glomerulopathy has been described in a macaque, in dogs, pigs and in a cat, published as renal glomerular fibrosis. Here, the authors present a case of collagenofibrotic glomerulopathy in a young European domestic shorthair cat, which developed a severe hypoproteinaemia, hypoalbuminaemia and proteinuria and showed a concurrent natural non-patent infection with the canid lungworm Angiostrongylus vasorum.

Additional Value of Second Harmonic Generation Microscopy in the Diagnosis of Feline Collagen Type III Glomerulopathy

“…Almost all affected dogs developed signs of chronic kidney disease within a year of birth and, in some cases, several puppies originating from the same litter developed signs early in life, suggesting a hereditary basis (Rørtveit et al, 2013(Rørtveit et al, , 2015Davis et al, 2020). In cats, only two cases have been documented: a 1-year-old neutered female Japanese cat (Nakamura et al, 1996) and an 11-month-old neutered male European Shorthair cat with concurrent Second Harmonic Generation Microscopy and Collagen Type III Glomerulopathy angiostrongylosis (Hilbe et al, 2020). No information regarding siblings and ancestors was available for the present case; however, the paediatric onset and the absence of major concurrent diseases could presumably suggest a genetic basis, similar to canine cases.…”

“…Collagen type III glomerulopathy (Col3GP), also called collagenofibrotic glomerulopathy, is a rare renal disease that has been described in humans, dogs, pigs, non-human primates and two cats (Shirota et al, 1995;Nakamura et al, 1996;Adachi et al, 2005;Duggal et al, 2012;Davis et al, 2020;Hilbe et al, 2020). In dogs, no sex or breed predilection has been established, although geographical distribution and familial onset are suggestive of an autosomal recessive inheritance (Rørtveit et al, 2012).…”