Collagenase inhibitor stimulates cleft formation during early morphogenesis of mouse salivary gland

Nakanishi, Yasuo; Sugiura, Fukashi; Kishi, Jun-Ichi; Hayakawa, Taro

doi:10.1016/0012-1606(86)90122-3

Cited by 138 publications

(68 citation statements)

References 10 publications

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“…MMPs are involved in extracellular matrix turnover during many reproductive processes (8)(9)(10)(11)(12)(13)(14), as well as during normal nonreproductive functions (15)(16)(17). These potent enzymes also play an important role in the pathological process of tumor invasion and metastasis (18)(19)(20)(21)(22) …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium.

Osteen

Rodgers

Gaire

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

175

144

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The hallmark of the menstrual cycle is extensive steroid-dependent tissue turnover. Estrogen mediates endometrial cell growth and structural remodeling, whereas progeserone suppresses estrogen-dependent proliferation and promotes cellular differentiation. In nonfertile cycles, tissue degradation and menstruation occur as a consequence of steroidal deprivation as the ovarian corpus luteum fails. Stromalepithelial interactions are recognized as a necesary component in mediating steroid-induced endometrial turnover. Specific mRNAs for metalloproteinases of the stromelysin family are expressed during endometrial growth and menstrual breakdown but are absent in the progestin-dominated secretory phase. This expression pattern suggss involvement of stromelysins in remodeling the extracellular matrix of the endometrium during tissue growth and breakdown and implicates progesteronE in the suppression of these enzymes. We examined the regulation of endometrial stromelysins in explant cultures and found no acute effect ofestradiol on their expression, whereas progesterone was a potent inhibitor of stromelysin expression. Progesterone also suppressed stromelysin expression in cultures ofisolated stromal cells, but epithelial cells were progesterone insensitive. Coculture ofrecombined stromal and epithelial cells restored steroidal suppression of the epithelial-specific metalloproteinase. Our data confirm that progesterone inhibits endometrial stromelysins and further demonstrate the necessity for a stromalderived factor(s) as a mediator of steroid suppression of an epithelial metalloproteinase.The human endometrium undergoes extensive estradiolinduced growth and remodeling during the proliferative phase of the menstrual cycle, followed by secretory maturation in response to postovulatory progesterone (1). This rapid and extensive degree of steroid-mediated tissue development, which rivals that of many neoplasias, appears to be a necessary component of providing an environment suitable for sustaining hemochorial placentation (2). In the absence of implantation and the continued progestational environment of pregnancy, the superficial functionalis region of the endometrium undergoes degradation and is expelled with menstrual blood flow. Several laboratories have recently described the expression of matrix metalloproteinases (MMPs) in the normal, cycling human endometrium (3-6). These enzymes degrade many components of the extracellular matrix, including proteoglycans, glycoproteins, and basement membrane collagens (7). Our studies (5, 6) identified a cell type-specific expression pattern of mRNAs coding for members of the stromelysin family only during the proliferative and premenstrual/menstrual stage of the cycle; none of the enzymes were identified during the progesterone-dominated secretory menstrual interval. This pattern of expression suggests an active role for stromelysins during growth-associated structural remodeling as well as during the extensive tissue breakdown associated with menstruation.MMPs of the st...

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Section: Discussionmentioning

confidence: 99%

“…The stromelysins also play a role in nonreproductive-tissue processes, such as organ morphogenesis during embryonic development (15)(16)(17), and in the pathological process of tumor invasion and!metastasis (18)(19)(20)(21)(22).…”

mentioning

confidence: 99%

Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium.

Osteen

Rodgers

Gaire

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

175

144

View full text Add to dashboard Cite

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“…In the salivary gland, collagenase appears to block epithelial bifurcation by preventing deposition of type I collagen fibrils, whereas inhibitors of collagenase cause the opposite phenotype [129]. In the kidney, selective inhibition of MMP-9 with function-perturbing antibodies causes abnormal branching, suggesting that MMP9 plays a role in renal branching morphogenesis [130].…”

Section: Structural Role Of Ecmmentioning

confidence: 99%

Comparative Mechanisms of Branching Morphogenesis in Diverse Systems

Sternlicht

Werb

2006

J Mammary Gland Biol Neoplasia

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Much progress has been made in recent years toward understanding mechanisms controlling branching morphogenesis, a fundamental aspect of development in a variety of invertebrate and vertebrate organs. To gain a deeper understanding of how branching morphogenesis occurs in the mammary gland, we compare and contrast the cellular and molecular events underlying this process in both invertebrate and vertebrate organs. Thus, in this review, we focus on the common themes that have emerged from such comparative analyses and discuss how they are implemented via a battery of signaling pathways to ensure proper branching morphogenesis in diverse systems.

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“…A recently identi¢ed candidate is the metalloprotease GON-1 (Blelloch & Kimble 1999). GON-1 is a member of the proteolytic enzyme family that degrades extracellular matrix components and so prepares the way for cell migration and tissue remodelling, including branching morphogenesis in mammalian lung, mammary tissue and kidney (Talhouk et al 1992;Nakanishi et al 1986;Lelongt et al 1997;Moerman 1999). …”

Section: Cell Specification In the Tubule Primordia Influences Tubulementioning

confidence: 99%

Coordinating cell fate and morphogenesis inDrosophilarenal tubules

Ainsworth

Wan

Skaer

2000

Phil. Trans. R. Soc. Lond. B

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Using the renal tubules of Drosophila as an example, we explore how cell speci¢cation leads to the morphogenetic movements that underlie the generation of tissue architecture. Taking two stages of development, we show ¢rst that the tubule cells are allocated by signalling between the endodermal and ectodermal compartments of the posterior gut. Activation of the Wnt pathway patterns the ectodermal anlage, resulting in the expression of tubule genes in a subset of cells and their eversion from the hindgut to form the tubule primordia. We argue that early gene expression directs these morphogenetic movements but not the complete programme of tubule di¡erentiation. In the second example we show that the allocation of the mitogenic tip cell lineage in each tubule is required not only for the normal pattern of cell division but also for the stereotyped three-dimensional arrangement of the mature tubules. Analysis of mutants in which the tip cell lineage is misspeci¢ed reveals that both daughters of the tip cell progenitor are required for the tubules to navigate through the body cavity, so that the distal tips locate in their characteristic positions. We show that the regulator of Rac, Myoblast city, is essential for this second morphogenetic process.

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Collagenase inhibitor stimulates cleft formation during early morphogenesis of mouse salivary gland

Cited by 138 publications

References 10 publications

Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium.

Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium.

Comparative Mechanisms of Branching Morphogenesis in Diverse Systems

Coordinating cell fate and morphogenesis inDrosophilarenal tubules

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