Collagenase for Enzymatic Debridement

Abstract

Debridement is an essential component of wound bed preparation. Various techniques of debridement are commonly used in clinical practice. This systematic review summarizes and ranks evidence concerning the safety and efficacy of the selective enzymatic debriding agent collagenase. Studies were identified comparing collagenase to inactive (sham) ointment and to alternate techniques for debridement including autolytic and surgical. A preponderance of evidence from this systematic review confirms that collagenase ointment is a safe and effective choice for debridement of cutaneous ulcers and burn wounds.

Collagenolytic activity in tissue extract of parborlasia corrugatusfrom antarctic region

“…Based on literature data (Park et al, 2002;Ramundo and Gray, 2009) and our own results we can conclude that collagenolytic activity in 1-3 peaks may indicate the presence in tissue extracts of P. corrugatus collagenases, the molecular weights of which are in the average range of 30 to 70 kDa, whereas activity in 4-7 peaks may be associated with low molecular weight collagenolytic serine proteases. So, a number of author note that in contrast to high-molecular bacterial and tissue collagenases of higher animals which molecular weights are found to vary from 30 to 150 kDa collagenolytic enzymes of marine invertebrates, are complex of isoenzymes with molecular weights up to 36 kDa (Kim et al, 2002;Salamonea, 2012).…”

Efficiency of Enzymatic Debridement in the Healing Process of Chronic Wounds in Small Animal Practice

“…The Iruxol ointment was applied once per day directly to the wound and the surrounding skin in a layer of at least [5], and R a m u n d o and G r a y [8]. Both studies found the treatment to be well-tolerated by patients and even to reduce pain at the wound site.…”

“…Studies in human medicine have shown that the use of collagenase increases the speed of healing and reduction in wound size, as well as reducing inflammation [6,8].…”

Evidence‐based topical management of chronic wounds according to the T.I.M.E. principle

“…In a systemic review, Ramundo et al demonstrated a higher efficacy in debridement of necrotic tissue with collagenase products compared to inactive preparation in decubitus ulcers and leg ulcers of various causes in placebo-controlled studies [23]. In a placebo-controlled study on a total of 84 patients with leg ulcers Falabella et al also observed no significant difference between the end points (reduction of pus exudation, pain, erythema and necrotic tissue).…”

“…Enzymatic Current data do not allow for a clear statement on the efficacy of enzymatic debridement [23,24].…”