Collagenase Clostridium histolyticum Injection for Plantar Fibromatosis (Ledderhose Disease)

Hammoudeh, Ziyad S.

doi:10.1097/prs.0000000000000433

Cited by 20 publications

(10 citation statements)

References 4 publications

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“…Nonsurgical treatment options include intralesional cortisone or collagenase injections [10], stretching, orthotics, anti-inflammatory drugs, physical therapy, shockwave therapy [11], and radiotherapy [12]. …”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of a Case of Ledderhose’s Disease: A Safe Plantar Approach to Subtotal Fasciectomy

Souza

Júnior

Mansilla

et al. 2015

Case Reports in Orthopedics

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Plantar fibromatosis, Ledderhose's disease, or Morbus Ledderhose is an uncommon benign nodular hyperplasia of the plantar aponeurosis. The aim of this paper was to report the case of a 47-year-old male patient who had concomitant Dupuytren's disease and failed all conservative measures. He was treated surgically with prompt and complete relief of symptoms postoperatively, and he has had no recurrence at the 2-year follow-up. In this richly documented case, we discuss details of the surgical technique and anatomy, which was important for a successful outcome and preventing complications. The technique for subtotal fasciectomy is reviewed and the relevance of the adequate choice of skin incision to prevent painful scarring, skin necrosis, and difficulties with shoe wearing is highlighted.

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Section: Discussionmentioning

confidence: 99%

Surgical Treatment of a Case of Ledderhose’s Disease: A Safe Plantar Approach to Subtotal Fasciectomy

Souza

Júnior

Mansilla

et al. 2015

Case Reports in Orthopedics

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“…A case study examining CCH for plantar fibromas (injected with 0.58 mg in 0.25 mL for a period of 3 injections with 1-month intervals) failed to show improvement in nodule size, softening or painful ambulation. 42 Side effects of CCH injections include erythema, ecchymosis, and pain at the injection site.…”

Section: Collagenasementioning

confidence: 99%

Plantar Fibromatosis: Pathophysiology, Surgical and Nonsurgical Therapies: An Evidence-Based Review

Carroll

Henshaw

Garwood

et al. 2018

Foot & Ankle Specialist

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“…Collagenase is a matrix metalloprotease that breaks down peptide bonds in order to dissolve interstitial collagen. Collagenase Clostridium histolyticum (CCH) is a mixture of two collagenases (AUX-1 and AUX-2) that has been shown to decrease contractions in Peyronie’s and Dupuytren’s and is currently being studied as a treatment option for PF 9,36. A recent study tested the effectiveness of CCH by injecting it into a nodule once a month for 3 months; this failed to improve nodule size, softening, or pain with ambulation 36.…”

Section: Non-operative Managementmentioning

confidence: 99%

“…Collagenase Clostridium histolyticum (CCH) is a mixture of two collagenases (AUX-1 and AUX-2) that has been shown to decrease contractions in Peyronie’s and Dupuytren’s and is currently being studied as a treatment option for PF 9,36. A recent study tested the effectiveness of CCH by injecting it into a nodule once a month for 3 months; this failed to improve nodule size, softening, or pain with ambulation 36. It is likely that the anatomical nature of PF (nodules) compared with that of Peyronie’s and Dupuytren’s (plaques and cords) plays a role in the ineffectiveness of CCH for treatment of the former.…”

Section: Non-operative Managementmentioning

confidence: 99%

The etiology, evaluation, and management of plantar fibromatosis

Young¹,

Sternbach²,

Willinger³

et al. 2018

ORR

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Plantar fibromatosis (Ledderhose disease) is a rare, benign, hyperproliferative fibrous tissue disorder resulting in the formation of nodules along the plantar fascia. This condition can be locally aggressive, and often results in pain, functional disability, and decreased quality of life. Diagnosis is primarily clinical, but MRI and ultrasound are useful confirmatory adjuncts. Given the benign nature of this condition, treatment has historically involved symptomatic management. A multitude of conservative treatment strategies supported by varying levels of evidence have been described mostly in small-scale trials. These therapies include steroid injections, verapamil, radiation therapy, extracorporeal shock wave therapy, tamoxifen, and collagenase. When conservative measures fail, surgical removal of fibromas and adjacent plantar fascia is often done, although recurrence is common. This review aims to provide a broad overview of the clinical features of this disease as well as the current treatment strategies being employed in the management of this condition.

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Collagenase Clostridium histolyticum Injection for Plantar Fibromatosis (Ledderhose Disease)

Cited by 20 publications

References 4 publications

Surgical Treatment of a Case of Ledderhose’s Disease: A Safe Plantar Approach to Subtotal Fasciectomy

Surgical Treatment of a Case of Ledderhose’s Disease: A Safe Plantar Approach to Subtotal Fasciectomy

Plantar Fibromatosis: Pathophysiology, Surgical and Nonsurgical Therapies: An Evidence-Based Review

The etiology, evaluation, and management of plantar fibromatosis

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