Collagenase Clostridium Histolyticum-aaes Injections for Volumetric Change of Cellulite Dimples and Gluteal Contouring

Abstract

BACKGROUND Collagenase clostridium histolyticum-aaes (CCH) is approved for the treatment of moderate-to-severe cellulite. OBJECTIVE This is a retrospective image review of subjects previously enrolled in Cohort 2 of the EN3835-305 trial to determine the effects of CCH on volumetric changes of cellulite dimples and overall gluteal contouring. METHODS In this retrospective analysis, photographs from Day 90 and Day 180 were superimposed on baseline images and the volumetric change of each treated cellulite dimple was quantified. Side-by-side photographs of the buttocks were also evaluated for change in gluteal contour using the Physician Global Aesthetic Improvement Scale (PGAIS). RESULTS Fifty-eight female subjects and 403 cellulite dimples were evaluated. Three-dimensional imaging analysis revealed a significant improvement in total negative dimple volume at both Day 90 and Day 180 of 27% and 26%, respectively (p , .001 and p 5 .002, respectively). At Day 90, the overall gluteal contour, as signified by the mean PGAIS among the 3 blinded dermatologists, was rated as +1 (improved) in 27% (n 5 17) of the subjects. At Day 180, the mean PGAIS was +1 (improved) or +2 (very much improved) in 39% (n 5 26) of the subjects. CONCLUSION CHH is an effective tool for treating cellulite dimples and improving gluteal contour.

Commentary on “Collagenase Clostridium Histolyticum-aaes Injections for Volumetric Change of Cellulite Dimples and Gluteal Contouring”

“…I read with interest the article titled, "Collagenase Clostridium Histolyticum-aaes Injections for Volumetric Change of Cellulite Dimples and Gluteal Contouring." 1 Edematous fibrosclerotic panniculopathy, cellulite, is a multietiology aesthetic pathologic condition that affects up to 98%. 2,3 There exists a complex relationship at the subdermis between dermal thickness, subcutaneous inflammation, adipose tissue architecture, and collagen-rich subdermal fibrous septa are a few structural characteristics noted at the macro and microscopic level.…”

Commentary on Improvement in Cellulite Appearance After a Single Treatment Visit With Acoustic Subcision: Long-Term Findings From a Multicenter Clinical Trial

“…Currently, combination treatments for cellulite can give the best results, including acoustic or mechanical subcision of the fibrous septae of cellulite, biostimulatory fillers for improvement in dimpling and skin quality, and skin tightening devices for accompanying skin laxity. 4,7,8 However, the high cost of these treatments is a barrier to entry for most patients, and multiple treatment visits are needed. The results can still be subtle after this combination approach.…”